《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (8): 710-712.

• 论文 • 上一篇    下一篇

汉语失语症患者的N400 研究

周亮，叶祥明，李厥宝，闻万顺   

  1. 浙江省人民医院康复科，浙江杭州市310014
  • 收稿日期:2012-05-10 修回日期:2012-07-14 出版日期:2012-08-25 发布日期:2012-08-25
  • 通讯作者: 叶祥明

Study on Event-Related Potential N400 for Chinese Aphasia Patients

ZHOU Liang, YE Xiang-ming, LI Jue-bao, et al   

  1. Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou 310014, Zhejiang, China
  • Received:2012-05-10 Revised:2012-07-14 Published:2012-08-25 Online:2012-08-25

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被引次数

11

摘要： 目的探讨汉语失语症患者事件相关电位N400 的特征和规律。方法对23 例失语症患者(失语组)和20 名正常人(对照组)进行西方失语症成套测验(WAB)检查和N400 检查，并对结果进行分析。结果失语组N400 差异波潜伏期较对照组延长，波幅较对照组增大。N400 潜伏期(r=-0.553, P=0.000)、波幅(r=-0.628, P=0.000)与失语症患者失语商(AQ)值具有显著相关性，波幅与命名能力具有显著相关性(r=-0.372, P=0.001)。结论N400 能客观反映汉语失语症语言功能障碍的严重程度，可以用于临床失语症患者语言功能尤其是命名能力的评估

关键词: 汉语, 失语症, 事件相关电位, N400

Abstract: Objective To investigate the feature of event-related potential N400 for Chinese aphasia patients. Methods 23 Chinese aphasia patients and 20 controls were evaluated with Western Aphasia Battery (WAB), and N400 was also measured. Results N400 latency was longer and N400 amplitude was higher in the aphasia group than in the control group. In aphasia group, the latency (r=-0.553, P=0.000) and amplitude of N400 (r=-0.628, P=0.000) correlated to the score of Aphasia Quotient (AQ), and the amplitude of N400 correlated to the score of anomia in WAB (r=-0.372, P=0.001). Conclusion Event-related potential N400 could reflect the level of language function impairment and it is a valuable index for evaluating language function, especially anomia level in Chinese aphasia patients

Key words: Chinese, aphasia, event-related potential, N400