《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (8): 760-762.

• 论文 • 上一篇    下一篇

青少年正常高值血压患者靶器官损伤相关性分析

高海1，严研1，田东华3，王丽凤2，李南1   

  1. 1.首都医科大学附属北京安贞医院抢救中心，北京市100029；2.空军后勤部门诊部，北京市100720；3.武警北京总队医院，北京市100027。
  • 收稿日期:2012-03-16 修回日期:2012-04-10 出版日期:2012-08-25 发布日期:2012-08-25
  • 通讯作者: 李南

Analysis of Target Organ Damage in Youth with Pre-hypertension

GAO Hai, YAN Yan, TIAN Dong-hua, et al   

  1. Emergency Center for Heart, Lung and Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
  • Received:2012-03-16 Revised:2012-04-10 Published:2012-08-25 Online:2012-08-25

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摘要： 目的探讨青少年正常高值血压患者靶器官损伤情况及其影响因素。方法选取2008 年~2010 年首都医科大学附属北京安贞医院急诊科、体检中心就诊青少年患者，分为正常高值血压患者组(n=32)和正常对照组(n=45)。比较各组左心室质量指数(LVMI)、左室舒张末期内径(LVDd)、舒张期室间隔厚度(IVST)、左室后壁厚度(LVPWT)、颈动脉内膜-中层厚度(IMT)、肾小球滤过率(GFR)。结果与正常对照组相比，正常高值血压组患者血压明显升高，正常高值血压组患者肥胖更多，存在更多高血压家族史(P<0.05)；两组LVDd、IVST、LVPWT、颈动脉IMT、GFR 无显著性差异(P>0.05)。与正常对照组相比，正常高值血压组患者LVMI 增加，E/A比值降低(P<0.05)。结论相比较动脉硬化及肾功能改变，正常高值血压青少年心脏靶器官损害更加突出，且多发生于肥胖青少年人群中。

关键词: 青少年, 正常高值血压, 靶器官损伤

Abstract: Objective To explore target organ damage in the youth with pre-hypertension. Methods 77 consecutive youth visiting our institution form 2008 to 2010 were divided into pre-hypertension group (n=32) and control group (n=45). The relevance of left ventricular mass index (LVMI), left ventricular end-diastolic diameter (LVDd), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), carotid plaque intima-media thickness (IMT) and glomerular filtration rate (GFR) were compared. Results The blood pressure of pre-hypertension group was higher than that of control group, and the pre-hypertension group followed higher family hypertension history (P<0.05). There was no difference in LVDd, IVST, LVPWT, carotid plaque IMT and GFR between 2 groups (P>0.05). Compared with the control group, LVMI increased (P<0.05) and the E/A ratio decreased (P<0.05). Conclusion Target organ damage in pre-hypertension youth is salient compared with changes in renal function and damage of arteriosclerosis, and heart damage is more often occurred in the obese youth with pre-hypertension.

Key words: youth, pre-hypertension, target organ damage