《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (10): 693-966.

• 论文 •    下一篇

颅内静脉窦血栓形成的危险因素及早期不良预后相关因素分析

赵惠卿，王安心，赵性泉   

  1. 首都医科大学北京天坛医院神经内科，北京市100050。
  • 收稿日期:2013-04-22 修回日期:2013-07-23 出版日期:2013-10-25 发布日期:2013-10-25
  • 通讯作者: 赵性泉

Risk Factors and Early Unfavourable Prognosis Factors of Cerebral Venous Sinus Thrombosis

ZHAO Hui- qing, WANG An- xin,ZHAO Xing-quan.   

  1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2013-04-22 Revised:2013-07-23 Published:2013-10-25 Online:2013-10-25

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摘要： 目的分析颅内静脉窦血栓形成(CVST)的危险因素及影响早期预后的相关因素。方法对68 例CVST患者的临床资料进行回顾性分析。按改良Rankin 量表(mRS)评分分为早期预后良好组与早期预后不良组。临床资料及其早期预后采用单因素和多因素Logistic 回归分析。结果与结论68 例CVST患者出院时早期预后良好37 例(54.4%)，早期预后不良31 例(45.6%)。单因素Logistic 回归分析结果显示，妊娠相关、中枢神经系统感染、高同型半胱氨酸血症、眼部症状、意识障碍、肢体瘫痪、伴继发性脑梗死、伴脑室受压/中线移位/全脑水肿8 项因素是早期预后不良的影响因素。多因素Logistic 回归分析显示，妊娠相关、中枢神经系统感染、高同型半胱氨酸血症、意识障碍、伴脑室受压/中线移位/全脑水肿是早期预后不良的独立影响因素。

关键词: 颅内静脉窦血栓, 危险因素, 预后

Abstract: Objective To analyze the risk factors and early prognosis factors of cerebral venous sinus thrombosis (CVST). Methods 68 patients with CVST were analyzed retrospectively. The patients were divided into early favorable prognosis group and early unfavorable prognosis group according to modified Rankin Scale (mRS). The clinical data and prognosis were analyzed by univariate analysis and multivariate logistic regression analysis. Results and Conclusion On discharge, there were 37(54.4%) cases and 31(45.6%) cases in the early favorable prognosis group and the early unfavorable prognosis group respectively. Univariate analysis showed that 8 factors, including pregnancy-associated factors, central nervous system infection, hyperhomocysteinemia, ocular symptoms, disturbance of consciousness, limb paralysis,secondary cerebral infarction and ventricular compression/midline shift/encephaledema were associated with the early prognosis.Multivariate logistic regression analysis showed that pregnancy-associated factors, central nervous system infection, hyperhomocysteinemia,disturbance of consciousness and ventricular compression/midline shift/encephaledema were the independent factors.

Key words: cerebral venous sinus thrombosis, risk factors, prognosis