《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (12): 1111-1113.

• 论文 • 上一篇    下一篇

索利那新对神经源性逼尿肌过度活动的效果观察

陈国庆，廖利民，吴娟，田钰   

  1. 1.首都医科大学康复医学院，北京市100068；2.中国康复研究中心北京博爱医院泌尿外科，北京市100068。
  • 收稿日期:2013-02-17 修回日期:2013-03-14 出版日期:2013-12-25 发布日期:2013-12-25
  • 通讯作者: 廖利民

Efficacy and Safety of Solifenacin in Neurogenic Detrusor Overactivity

CHEN Guo-qing, LIAO Li-min, WU Juan, et al.   

  1. Capital Medical University School of Rehabilitation Medicine; Department of Urology, Beijing Bo'ai Hospital, China Rehabilitation Research Centre,Beijing 100068, China
  • Received:2013-02-17 Revised:2013-03-14 Published:2013-12-25 Online:2013-12-25

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摘要： 目的评价索利那新治疗神经源性逼尿肌过度活动的有效性和安全性。方法选取神经源性逼尿肌过度活动患者50例，口服索利那新5 mg/d，记录服药前，服药后2 周、12 周的排尿日记以及患者感知膀胱症状量表评分(PPBC-S)，并记录不良反应。结果治疗2 周、12 周后每次导尿量由服药前的(224.2±15.7) ml增加到(302.6±23.3) ml和(301.3±21.1) ml (P<0.05)；每天漏尿量由服药前的(753.9±121.7) ml 减少到(444.1±87.1) ml 和(449.1±89.2) ml (P<0.05)；PPBC-S 评分由服药前的(5.12±0.072)降低到(4.36±0.073)和(4.36±0.068)(P<0.05)。有3 例(6%)患者出现口干，无患者诉眼干、视物模糊。结论索利那新治疗神经源性逼尿肌过度活动安全有效，可以增加每次导尿的导尿量，减少漏尿量，且副作用小，能明显改善患者生活质量。

关键词: 神经源性逼尿肌过度活动, 索利那新, 有效性, 安全性

Abstract: Objective To assess the efficacy and safety of solifenacin in patients with neurogenic detrusor overactivity (NDO). Methods 50 patients with NDO received solifenacin 5 mg/d. During the treatment period, the voiding diary, Patient Perception of Bladder Condition-Scale (PPBC-S) and side effects were recorded. Results 2 weeks and 12 weeks later, the volume of the catheterization every time increased from (224.2±15.7) ml at baseline to (302.6±23.3) ml and (301.3±21.1) ml (P<0.05); the volume of leakage every day decreased from (753.9±121.7) ml to (444.1±87.1) ml and (449.1±89.2) ml (P<0.05); PPBC-S score decreased from (5.12±0.072) to (4.36±0.073) and (4.36±0.068) (P<0.05). There were 3 cases (6%) with dry mouth, and no patients complained dry eyes and blurred vision. Conclusion Solifenacin is safe and effective, and can significantly improve the quality of life in patients with NDO.

Key words: neurogenic detrusor overactivity, solifenacin, efficacy, safety