《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (2): 101-103.

• 论文 •    下一篇

莫诺苷对二磷酸腺苷诱导局灶性脑缺血再灌注大鼠血小板聚集的影响

程华，孙芳玲，王晓锋，艾厚喜，张丽，陈乃宏，王文   

  1. 1.首都医科大学宣武医院药物研究室，北京市100053；2. 中国医学科学院药物研究所，北京市100050。
  • 收稿日期:2012-09-05 修回日期:1900-01-01 出版日期:2013-02-25 发布日期:2013-02-25
  • 通讯作者: 王文

Effect of Morroniside on Platelet Aggregation in Focal Cerebral Ischemia/Reperfusion in Rats

CHENG Hua, SUN Fang-ling, WANG Xiao-feng, et al.   

  1. Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • Received:2012-09-05 Revised:1900-01-01 Published:2013-02-25 Online:2013-02-25

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摘要： 目的观察莫诺苷对二磷酸腺苷(ADP)诱导的局灶性脑缺血再灌注大鼠血小板聚集指数的影响。方法用线栓法制备大鼠局灶性脑缺血再灌注模型。将48 只Sprague-Dawley 大鼠随机分为假手术组，模型组，莫诺苷低、中、高剂量组(30 mg/kg、90mg/kg、270 mg/kg)和阿司匹林组(10 mg/kg)。利用透光比浊法检测大鼠血小板聚集率。结果与模型组相比，高剂量莫诺苷组血小板最大聚集率显著降低(P<0.001)。结论莫诺苷具有抑制血小板聚集的作用。

关键词: 莫诺苷, 二磷酸腺苷, 血小板聚集, 缺血/再灌注, 大鼠

Abstract: Objective To explore the effects of morroniside on platelet aggregation induced by adenosine diphosphate (ADP) in focal cerebral ischemia/reperfusion in rats. Methods 48 Sprague-Dawley rats were randomly divided into sham group, model group, morroniside dose groups (30 mg/kg, 90 mg/kg, 270 mg/kg) and acetyl salicilic acid (ASA) group (10 mg/kg). The model of middle cerebral artery occlusion (MCAO) was established in all rats except the sham group. Born's turbidimetry was used to measure platelet aggregation rate in rats of MCAO model (in vivo). Results Compared with the model group, the platelet aggregation decreased significantly in the morroniside high dose group (P<0.001). Conclusion Morroniside has the effect of anti-platelet aggregation in focal cerebral ischemia/reperfusion in rats.

Key words: morroniside, adenosine diphosphate, platelet aggregation, ischemia/reperfusion, rats