《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (2): 137-141.

• 论文 • 上一篇    下一篇

per2 基因参与边缘系统昼夜节律的研究进展

朱毅，郭佳宝，李凝，岳雨珊，张文毅，谢斌   

  1. 1.南京中医药大学第二临床医学院，江苏南京市210046；2.中南大学湘雅二医院康复医学科，湖南长沙市410011；3.江苏省人民医院钟山康复医院，江苏南京市210000。
  • 收稿日期:2013-03-28 修回日期:1900-01-01 出版日期:2014-02-25 发布日期:2014-02-25

Advance in per2 Gene on Circadian Rhythm of Limbic System (review)

ZHU Yi, GUO Jia-bao, LI Ning, et al.   

  1. the 2nd Clinical Medical School, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, Jiangsu, China
  • Received:2013-03-28 Revised:1900-01-01 Published:2014-02-25 Online:2014-02-25

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被引次数

2

摘要： 各种生物体生理、生化和行为过程都呈现一定的昼夜节律变化，并受到生物钟的调控。per2 基因是重要的生物钟基因之一，主要分布在下丘脑的视交叉上核以及中央杏仁核、终纹床核、海马等边缘系统结构，通过参与该系统昼夜节律的调节对情绪和内脏活动产生影响。中枢per2 基因的节律性通过对光信号、类固醇激素及其他相关递质的整合调节下丘脑-垂体-肾上腺(HPA)轴，作用于周围靶器官呈现昼夜节律性运动。本文对per2 的形态学和生物学及其参与边缘系统对情绪、内脏活动昼夜节律调节机理做一概述。

关键词: per2 基因, 边缘系统, 昼夜节律, 生物钟基因, 内脏活动, 综述

Abstract: Per2 gene plays one of the most critical roles of clock gene which modulates circadian rhythm both in the physiological, biochemical and behavioral processes of organisms. The distributions of per2 gene include suprachiasmatic nucleus of the hypothalamus, central nucleus of amygdala, bed nucleus of the stria terminalis, hippocampus and other components of limbic system; it affects the emotional and visceral activities through participating in the system of circadian rhythm. The central per2 gene regulates the hypothalamus-pituitaryadrenal axis through integration of light input, steroid hormones and other neurotransmitters integration, acting on the target organs, and presentes a circadian rhythm of movement. This article reviewed the morphology and biology of per2 gene, and its participation in limbic system regulating the circadian rhythm of motional and visceral activities.

Key words: per2 gene, limbic system, circadian rhythm, clock gene, visceral motility, review