《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (2): 142-147.

• 论文 • 上一篇    下一篇

骨骼肌纤维化的细胞与分子机制研究进展

邓修元，吴志彬，杨忠   

  1. 1.第三军医大学学员旅一队，重庆市400038；2.第三军医大学大坪医院康复理疗科，重庆市400038；3.第三军医大学检验系临床血液学教研室，重庆市400038。
  • 收稿日期:2013-04-10 修回日期:2013-06-07 出版日期:2014-02-25 发布日期:2014-02-25

Fibrosis in Skeletal Muscle: Celluar and Molecular Mechanism (review)

DENG Xiu-yuan, WU Zhi-bin, YANG Zhong.   

  1. Squadron One of Student Brigade, Third Military Medical University, Chongqing 400038, China
  • Received:2013-04-10 Revised:2013-06-07 Published:2014-02-25 Online:2014-02-25

PDF (PC)

被引次数

7

摘要： 骨骼肌是具有完全再生能力的组织，在急性创伤性损害后骨骼肌多能完成再生修复。当出现慢性退行性病变如进行性肌营养不良和反复肌纤维损伤时，骨骼肌修复过程常伴随着纤维化的发生。通过近十余年来对骨骼肌纤维化机制的研究，发现多种细胞和系列调控分子参与该过程，特别是肌卫星细胞来源的肌成纤维细胞等相关细胞和转化生长因子β(TGF-β)等促纤维化发展的生长因子。本文就骨骼肌纤维化的细胞分子机制及相关拮抗策略进行综述。

关键词: 骨骼肌, 纤维化, 肌卫星细胞, 肌成纤维细胞, 转化生长因子β, 综述

Abstract: Skeletal muscle has high regenerative capability. It is able to regenerate completely after acute traumatic damage, while the repairing process often accompanied by fibrosis in the chronic degenerative conditions such as muscular dystrophy and repeated muscle fiber damage. Through in-depth study on the mechanisms of skeletal muscle fibrosis in the past decade, it has been found that a variety of cells and regulatory molecules involved in the process, especially muscle satellite cells-derived myofibroblasts, transforming growth factor β (TGF-β) and other fibrosis promoting growth factors. This review focused on the cellular and molecular mechanisms of the skeletal muscle fibrosis and relevant antagonistic strategies.

Key words: skeletal muscle, fibrosis, satellite cell, myofibroblast, transforming growth factor β, review