《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (3): 259-261.

• 论文 • 上一篇    下一篇

β-七叶皂苷钠对重型脑损伤患者血清肿瘤坏死因子-α的影响

邓元央，黄海能，韦桂源，黄华东，罗起胜，符黄德，李传玉   

  1. 右江民族医学院附属医院神经外科，广西百色市533000。
  • 收稿日期:2013-09-04 修回日期:2013-10-17 出版日期:2014-03-25 发布日期:2014-03-25

Effect of β- aescine Sodium on Tumor Necrosis Factor α in Severe Traumatic Brain Injury

DENG Yuan-yang, HUANG Hai-neng,WEI Gui-yuan, et al.   

  1. Neurosurgery Department, Affiliated Hospital, Youjiang Medical College for Nationality, Baise 533000, Guangxi, China
  • Received:2013-09-04 Revised:2013-10-17 Published:2014-03-25 Online:2014-03-25

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被引次数

5

摘要： 目的研究β-七叶皂苷钠对重型脑损伤患者血清肿瘤坏死因子-α(TNF-α)的影响及其临床意义。方法60 例重型脑损伤患者分为治疗组和对照组各30 例，对照组给予神经外科常规治疗，治疗组在常规治疗基础上给予β-七叶皂苷钠。分别于治疗前，治疗后第1、2、3、5、7 天测定血清TNF-α，于治疗3 个月后进行格拉斯哥结局量表(GOS)评分。结果治疗3 d 后，治疗组血清TNF-α较对照组下降(P<0.05)；治疗3 个月后，治疗组GOS评分优于对照组(P<0.05)。结论β-七叶皂苷钠是治疗重型脑损伤的有效手段之一，血清TNF-α的动态变化能够预测治疗结局。

关键词: β-七叶皂苷钠, 重型颅脑损伤, 肿瘤坏死因子-α

Abstract: Objective To study the effect of β-aescine sodium on tumor necrosis factor α (TNF-α) in patient with severe traumatic brain injury and the clinical significance. Methods 60 patients with severe traumatic brain injury were divided equally into control group (n=30) and treatment group (n=30), who accepted routine therapy and further β-aescine sodium respectively. The serum TNF-α was determined before and 1 d, 2 d, 3 d, 5 d and 7 d after treatment. The patients were assessed with Glasgow Outcome Scale (GOS) 3 months after treatment.Results There was significant difference of serum TNF-α between treatment group and control group since 3 d after treatment (P<0.05). The score of GOS was better in the treatment group than in the control group 3 months after treatment (P<0.05). Conclusion β-aescine sodium is effective on severe traumatic brain injury. Level of TNF-α may be related with the outcome of patients with severe traumatic brain injury.

Key words: β-aescine sodium, severe traumatic brain injury, tumor necrosis factor α