《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (9): 870-872.

• 临床研究 • 上一篇    下一篇

鼠神经生长因子对一氧化碳中毒迟发性脑病患者认知功能及日常生活活动能力的影响

高亚南，徐琛，李文杰，张晓强，李翔，许永利，陈雪丽
   

  1. 北京老年医院康复医学科，北京市100095
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-09-25 发布日期:2014-09-25

Effect of Mouse Nerve Growth Factor on Cognitive Function and Activities of Daily Living in Patients with Delayed Encephalopathy after Acute

GAO Ya-nan, XU Chen, LI Wen-jie, ZHANG Xiao-qiang, LI Xiang, XU Yong-li, CHEN Xue-li.
   

  1. Department of Rehabilitation, Beijing Geriatric Hospital, Beijing 100095, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-09-25 Online:2014-09-25

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被引次数

13

摘要： 目的探讨鼠神经生长因子对一氧化碳中毒迟发性脑病患者认知功能及日常生活活动能力的影响。方法一氧化碳中毒迟发型脑病患者35 例随机分为治疗组(n=18)和对照组(n=17)。两组均接受系统高压氧治疗和药物治疗，治疗组在此基础上行鼠神经生长因子治疗。治疗前及治疗12 周后，分别采用洛文斯顿作业疗法认知评定量表(LOTCA)、改良Barthel 指数(MBI)对患者进行评定。结果治疗后，治疗组LOTCA、MBI评分改善优于对照组(P<0.05)。结论鼠神经生长因子可有效改善一氧化碳中毒迟发性脑病患者的认知功能，提高其日常生活活动能力。

关键词: 迟发性脑病, 一氧化碳中毒, 鼠神经生长因子, 日常生活活动能力, 认知功能

Abstract: Objective To observe the effect of mouse nerve growth factor (mNGF) on cognitive function and activities of daily living (ADL) in patients with delayed encephalopathy after acute carbon monoxide poisoning. Methods 35 patients with delayed encephalopathy after acute carbon monoxide poisoning were randomly divided into treatment group (n=18) and control group (n=18). Both groups accepted hyperbaric oxygen and medication, while the treatment group was injected with mNGF 20 mg a day in addition for 12 weeks. They were assessed with Loewenstein Occupational Therapy Cognitive Asessment (LOTCA) and modified Barthel Index (MBI) before and after treatment. Results The scores of LOTCA and MBI improved more in the treatment group than in the control group after treatment (P<0.05). Conclusion mNGF can obviously improve cognitive function and ADL for patients with delayed encephalopathy after acute carbon monoxide poisoning.

Key words: delayed encephalopathy, carbon monoxide poisoning, mouse nerve growth factor, activities of daily living, cognitive functio