《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (9): 873-876.

• 临床研究 • 上一篇    下一篇

沈阳汉族人群细胞色素P450 酶1A2基因多态性与慢性阻塞性肺疾病易感性的关联

赵龙1，李莹2，陈达3，马涛4，许林晖1，夏书月1
   

  1. 1.沈阳医学院附属中心医院呼吸科，辽宁沈阳市110024；2.沈阳市红十字会医院呼吸内科，辽宁沈阳市110013；3.中国医科大学附属第四医院急诊科，辽宁沈阳市110032；4.中国医科大学附属第一医院急诊科，辽宁沈阳市110001。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-09-25 发布日期:2014-09-25

Relationship between Cytochrome P450 1A2 Gene Polymorphism and Susceptibility to Chronic Obstructive Pulmonary Disease

ZHAO Long, LI Ying, CHEN Da, MA Tao, XU Lin-hui, XIA Shu-yue.
   

  1. Department of Respiratory Medicine, Central Hospital of Shenyang Medical College, Shenyang, Liaoning 100024, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-09-25 Online:2014-09-25

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被引次数

5

摘要： 目的探讨沈阳市汉族人群细胞色素P450 酶1A2 (CYP1A2)基因多态性与慢性阻塞性肺疾病(COPD)遗传易感性的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RELP)方法检测100 例COPD患者和年龄、性别匹配的100 名健康人CYP1A2 基因不同位点多态性等位基因及基因型频率分布。结果两组不同位点多态性基因型频率分布均符合遗传性Hardy-Weinberg平衡(均P>0.05)。COPD患者和健康人的1D和1F基因型和等位基因频率分布有显著性差异(P<0.05)，1C和1E基因型和等位基因频率分布无显著性差异(P>0.05)。结论CYP1A2 基因1D和1F多态性可能与COPD遗传易感性增加有关。

关键词: 慢性阻塞性肺疾病, 细胞色素P450酶1A2, 基因多态性, 易感性

Abstract: Objective To investigate the relationship between cytochrome P450 1A2 (CYP1A2) gene polymorphism and susceptibility to chronic obstructive pulmonary disease (COPD). Methods CYP1A2 gene polymorphisms in 100 COPD cases and 100 healthy controls were tested with polymerase chain reaction- restriction fragment length polymorphism (PCR- RELP). Results Genotype frequencies of 4 SNPs in both the COPD and control groups were in accordance with Hardy-Weinberg equilibrium (P>0.05). There was significant difference between the COPD and control groups in genotype and allele frequencies of 1D and 1F (P<0.05), but not of 1C and 1E (P>0.05). Conclusion CYP1A2*1D and CYP1A2*1F polymorphisms may play an important role in the development of COPD.

Key words: chronic obstructive pulmonary disease, cytochrome P450 1A2, gene polymorphism, susceptibility