《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (01): 39-041.

• 基础研究 • 上一篇    下一篇

即时高压氧对大鼠局灶性脑缺血后梗死体积的影响

李纲，张志强，张立新
   

  1. 中国医科大学附属盛京医院康复中心，辽宁沈阳市110000。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-01-25 发布日期:2015-01-25

Effect of Immediate Hyperbaric Oxygen on Infarct Size in Rats after Focal Cerebral Ischemia

LI Gang, ZHANG Zhi-qiang, ZHANG Li-xin.
  

  1. LI Gang, ZHANG Zhi-qiang, ZHANG Li-xin.
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-01-25 Online:2015-01-25

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被引次数

4

摘要： 目的探讨即时高压氧对大鼠局灶性脑缺血后梗死体积的影响。方法Sprague-Dawly 大鼠随机分成对照组(n=9)、高压空气组(n=9)、高压氧组(n=9)、假手术组(n=5)，前三组应用线栓法制作大鼠局灶性脑缺血模型，高压空气组、高压氧组在高压氧舱内造模，高压氧组于造模后立即行高压氧治疗。各组大鼠均于术后6 h 断头取脑，计算各组大鼠脑梗死占脑总体积百分比。结果与对照组相比，高压氧组及高压空气组梗死百分比均显著减少(P<0.001)，高压氧组减少得更显著(P<0.001)。结论即时高压氧治疗能够降低大鼠脑局灶性缺血后梗死体积。

关键词: 脑缺血, 即时高压氧, 梗死体积, 大鼠

Abstract: Objective To investigate the effect of immediate hyperbaric oxygen on focal cerebral ischemia of rats. Methods Sprague-Dawly rats were randomly divided into control group (n=9), hyperbaric air group (n=9), hyperbaric oxygen group (n=9) and sham group (n=5). The middle cerebral arteries were occluded in the former 3 groups, while the hyperbaric air group and the hyperbaric oxygen group operated in the hyperbaric chamber, and the hyperbaric oxygen group accepted hyperbaric oxygen immediately after operation. All the rats were sacrificed 6 hours after operation and the percentage of volume of infarction in the brain slices was calculated. Results The percentage of infarction decreased in both hyperbaric oxygen group and hyperbaric air group compared with the control group (P<0.001), and decreased more in the hyperbaric oxygen therapy than in the hyperbaric air group (P<0.001). Conclusion Immediate hyperbaric oxygen therapy can reduce infarct size in rats after focal cerebral ischemia.

Key words: cerebral ischemia, immediate hyperbaric oxygen, infarct size, rats