《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (02): 153-156.

• 基础研究 • 上一篇    下一篇

吸氧对听感觉门控P50 的影响

于秋红1，陈昭燃2，张红霞1，刘亚玲1，薛连璧1   

  1. 1.首都医科大学附属北京天坛医院高压氧科，北京市100050；2.首都医科大学神经生物系高级脑功能中心，北京市100069。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-02-25 发布日期:2015-02-25

Effect of Oxygen Inhalation on Auditory Sensory Gating P50

YU Qiu-hong, Andrew CN CHEN, ZHANG Hong-xia, LIU Ya-ling, XUE Lian-bi   

  1. Department of Hyperbaric Oxygen, Beijing Tiantan Hospital, Capital Medical Universtity, Beijing 100050, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-02-25 Online:2015-02-25

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摘要： 目的研究呼吸纯氧对健康人听感觉门控P50 的影响。方法右利手、健康男性大学生志愿者28 名，根据随机数字表分为对照组(n=12)和实验组(n=16)。佩戴面罩，对照组呼吸空气，实验组呼吸医用纯氧60 min。应用条件-测试刺激，记录吸氧前(pre0)、吸氧20 min (Oxy20)、吸氧50 min (Oxy50)、吸氧后30 min (post30)的脑电图，计算听觉P50 潜伏期和P50 感觉门控电位(S1 与S2 振幅之差)。结果S1 刺激在4 个时间点各组P50 潜伏期相对稳定(P>0.7)；吸氧50 min 时，实验组比对照组P50 潜伏期缩短(P<0.05)。S2 刺激在4 个时间点各组P50 潜伏期相对稳定(P>0.30)，两组间比较无显著性差异(P>0.05)。对照组P50 门控电位比较稳定(P=0.70)，而实验组随吸氧时间逐渐延长，电位越来越高，停止吸氧后，电位迅速回落，Oxy20 和post30 (P=0.04)、Oxy50 和post30 (P=0.02)相比均有显著性差异。组间比较，4 个时间点均无显著性差异(P>0.05)。结论健康人吸60 min 纯氧，可能缩短对刺激的反应时间，有增强听觉门控电位的趋势。

关键词: 吸氧, 听感觉门控, P50

Abstract: Objective To explore the effect of oxygen inhalation on auditory sensory gating P50 in healthy human brain. Methods 28 healthy male academician right-handed were included. They were divided into control group (n=12) and experiment group (n=16) according to the random numerical table, and blinded about groups. The subjects inhaled pure oxygen in the experiment group, and air in the control group through a mask for 60 min. The electroencephalograph was recorded while an auditory paired-click sensory gating test was conducted during 4 study periods: before inhalation (pre0), inhale for 20 min (Oxy20) and 50 min (Oxy50), and 30 min after inhalation (post30). The latency and amplitude (S1-S2) of auditory sensory gating P50 were calculated. Results The latencies of P50 from S1 were stable in each group (P>0.7), and the latency of Oxy50 was shorter in the experiment group than in the control group (P<0.05). The latencies from S2 were stable in each group (P>0.30), and there was no significant difference between groups in all the time points (P>0.05). The amplitudes of (S1-S2) of P50 were stable in the control group (P=0.70), and was higher on Oxy20 (P=0.04) and Oxy50 (P=0.02) than post30 in the experiment group. There was no difference between the groups in all the time points (P>0.05). Conclusion Oxygen inhalation may be helpful to shorten the active time to stimulate, and trend to enhancing the amplitude of P50.

Key words: oxygen inhalation, auditory sensory gating, P50