《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (03): 341-343.

• 临床研究 • 上一篇    下一篇

单唾液酸四己糖神经节苷酯钠注射液对痉挛型脑性瘫痪的疗效

李哲1，王和强1，刘兵1，赖新波1，李熠1，叶耀华1，李锦嫦1，黄战武1，张光正1，方座华2
   

  1. 1.东莞市康复医院，广东东莞市523119；2.东莞市中医院，广东东莞市523006。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-03-25 发布日期:2015-03-25

Effect of Monosialotetrahexosyl Ganglioside Sodium Injection on Spastic Cerebral Palsy

LI Zhe1, WANG He-qiang1, LIU Bing1, LAI Xin-bo1, LI Yi1, YE Yao-hua1, LI Jin-chang1, HUANG Zhan-wu1, ZHANG Guang-zheng1, FANG Zuo-hua2
   

  1. 1. Relihablition Hospital of Dongguan, Dongguan, Guangdong 523119, China; 2. Dongguan Hospital of Traditional Chinese Medicine, Dongguan, Guangdong 523006, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-03-25 Online:2015-03-25

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摘要： 目的观察单唾液酸四己糖神经节苷酯钠注射液(GM1)治疗痉挛型脑瘫的临床疗效。方法98 例脑瘫患儿随机分为对照组(Bobath 疗法)50 例和治疗组(GM1 加Bobath 疗法)48 例，治疗90 d。治疗前后采用儿童功能独立性测量(WeeFIM)、粗大运动功能测量(GMFM)和格赛尔发育量表(GDS)进行评定。结果治疗后，两组WeeFIM、GMFM和GDS 中的大运动、精细动作、个人-社交和适应性均有改善(P<0.05)，治疗组较对照组改善更多(P<0.05)。结论GM1 能进一步促进痉挛型脑瘫患儿功能恢复。

关键词: 脑性瘫痪, 痉挛型, 神经节苷酯, 日常生活活动能力, 运动功能, 发育

Abstract: Objective To observe the clinical effect of monosialotetrahexosyl ganglioside sodium injection (GM1) on spastic cerebral palsy. Methods 98 children with spastic cerebral palsy were randomly divided into control group (n=50) and treatment group (n=48). Both groups received Bobath approach, and the treatment group received GM1 in addition. They were assessed with Functional Independence Measure for Children (WeeFIM), Gross Motor Function Measure (GMFM) and Gesell Development Schedule (GDS) before and after 90 days of treatment. Results The scores of WeeFIM, all the dimensions of GMFM and the gross motor, fine motor, personal-social and adaption of the GDS improved in both groups after treatment (P<0.05), and improved more in the treatment group than in the control group (P< 0.05). Conclusion GM1 may further improve the recovery of function for children with spastic cerebral palsy.

Key words: cerebral palsy, spastic, ganglioside, activities of daily living, motor function, development