《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (04): 387-390.

• 专题 • 上一篇    下一篇

紫衫醇对脊髓损伤后神经细胞骨架微管作用研究进展

王玉明 1，唐丽 2，杨德刚 1，杨华东 1
   

  1. 1.中国康复研究中心北京博爱医院脊柱脊髓神经功能重建科，北京市100068；2.首都医科大学康复医学院，北京市100068。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-04-25 发布日期:2015-04-25

Advance of Application of Taxol in Microtubule Skeleton Function of Nerve Cells after Spinal Cord Injury (review)

WANG Yu-ming1, TANG Li2, YANG De-gang1, YANG Hua-dong1
   

  1. 1. Department of Spinal and Neural Functional Reconstruction, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China; 2. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-04-25 Online:2015-04-25

PDF (PC)

被引次数

3

摘要： 促进脊髓损伤后轴突再生的药物一直受到高度关注。神经元轴突生长、延长与分枝是细胞骨架介导的生物学过程，微管对轴突结构调整与生长起重要作用。药物紫衫醇能适度稳定微管，消除轴突再生的阻碍，对脊髓损伤后轴突再生修复有影响。紫衫醇主要用于抗肿瘤治疗。本文就紫衫醇与神经元细胞骨架微管的研究进展进行综述。

关键词: 紫衫醇, 脊髓损伤, 微管, 综述

Abstract: The drugs promoting axon regeneration after spinal cord injury has been receiving high attention. Growth, extending and branching of neuron axon is a biological process mediated by cytoskeleton, and microtubule plays an important role on axon structure adjustment and growth. Taxol can reasonably stabilize microtubules, eliminate the obstacles of axon regeneration, and effect on axonal regeneration repair after spinal cord injury. Taxol is mainly used for anti-tumor therapy. This paper reviewed the researches on taxel and neuronal cytoskeletal microtubule.

Key words: taxol, spinal cord injury, microtubule, review