《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (06): 657-661.

• 特稿 • 上一篇    下一篇

运动预处理诱导脑缺血耐受机制的研究进展

吴孝军 1，朱路文 2，李宏玉 1，唐强 2   

  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-06-25 发布日期:2015-06-25

Advance in Mechanism of Cerebral Ischemia Tolerance Induced by Exercise Preconditioning (review)

WU Xiao-jun1, ZHU Lu-wen2, LI Hong-yu1, TANG Qiang2
  

  1. 1. Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China; 2. The Second Hospital Affiliated to Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-06-25 Online:2015-06-25

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摘要： 运动预处理可诱导脑缺血性损伤耐受，具有显著的脑神经系统保护作用。运动预处理改善脑缺血性损伤的具体作用机制较为复杂，涉及多靶点、多途径的调控，其中抑制细胞凋亡、促进脑神经血管生成、抑制谷氨酸的过度激活以及调控炎症反应是运动预处理诱导脑缺血耐受的关键机制。然而运动预处理诱导脑缺血耐受的机制远不止于此，有待进一步研究和发现。

关键词: 脑缺血, 耐受, 运动预处理, 综述

Abstract: Cerebral ischemia tolerance was induced by exercise preconditioning, which protected the brain from injury. The detailed mechanism of exercise preconditioning protecting cerebral ischemia injury was complicated, which involving the regulation of multiple target point and multi-path, such as inhibiting cell apoptosis, promoting angiogenesis in the brain, inhibiting the excessive activation of glutamic acid as well as the regulation of inflammation. More mechanisms were still unknown.

Key words: cerebral ischemia, tolerance, exercise preconditioning, review