《中国康复理论与实践》

《中国康复理论与实践》

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丰富环境促进缺血缺氧性脑损伤修复的研究进展①

宋名杨1，朱路文2，叶涛1，姜云飞1，唐强2   

  1. 1.黑龙江中医药大学，黑龙江哈尔滨市150040；2.黑龙江中医药大学附属第二医院，黑龙江哈尔滨市150001。
  • 出版日期:2016-01-25 发布日期:2016-05-23

Enriched Environment for Hypoxic-ischemic Brain Damage (review)

SONG Ming-yang1, ZHU Lu-wen2, YE Tao1, JIANG Yun-fei1, TANG Qiang2   

  1. 1. Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China; 2. The Second Hospital Affiliated to Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China
  • Published:2016-01-25 Online:2016-05-23

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摘要： 缺血缺氧性脑损伤是围生期窒息的严重并发症。丰富环境是促进感觉、认知及行为能力提高的居住条件。丰富坏境能在行为学、形态学及分子生物学三个层面促进缺血缺氧性脑损伤的修复。丰富环境可能通过调控各种因子的分泌与释放，增强突触可塑性，诱导神经元再生，抑制其凋亡，促进缺血缺氧性脑损伤后行为学及形态学的改变。

关键词: 缺血缺氧性脑损伤, 丰富环境, 康复, 机制, 综述

Abstract: Hypoxic-ischemic brain damage is a serious complication of perinatal asphyxia. Enriched environment is the living conditions for the promotion of feeling, cognition and behavior. Enriched environment may promote the repairing of hypoxic-ischemic brain damage in term of praxiology, morphology and molecular biology, that enriched environment may regulate the secretion and release of various factors, and enhance synaptic plasticity, induce neuron regeneration, inhibit its apoptosis, and result in ethological and morphological recovery.

Key words: hypoxic-ischemic brain damage, enriched environment, rehabilitation, mechanisms, review