《中国康复理论与实践》

《中国康复理论与实践》

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女性脊髓损伤后高催乳素血症的研究进展①

英小倩1，张军卫1,2   

  1. 1.首都医科大学康复医学院，北京市100068；2.中国康复研究中心北京博爱医院脊柱脊髓外科，北京市100068。
  • 出版日期:2016-03-25 发布日期:2016-06-01

Hyperprolactinemia in Female Patients with Spinal Cord Injury (review)

YING Xiao-qian1, ZHANG Jun-wei1,2   

  1. 1. Capital Medical University School of Rehabilitation Medcine, Beijing 100068, China; 2. Department of Spine Surgery, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
  • Published:2016-03-25 Online:2016-06-01

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摘要： 部分非妊娠期女性脊髓损伤患者伤后出现与妊娠无关的血浆催乳素水平升高，表现为不同程度的月经异常、溢乳；部分男性脊髓损伤后也会出现。这种高催乳素血症与脊髓损伤的节段及损伤程度无关，且持续时间各不相同。脊髓损伤后催乳素增高及闭经可能与伤后对促甲状腺激素释放激素反应增强有关。另外，胸部损伤、垂体挫伤、脑内啡肽升高、脊髓神经通路的刺激、应激等都是可疑因素。溴隐亭治疗可能有效。

关键词: 脊髓损伤, 女性, 高催乳素血症, 综述

Abstract: Some female spinal cord injured patients may present a raise of serum prolactin which is irrelevant with pregnancy, and results in irregular menstruation and galactorrhea. Hyperprolactinemia may even happen in men after spinal cord injury. This kind of hyperprolactinemia does not relate with the level or severity of spinal cord injury, and maintains for various time. The hypersensitivity to thyrotropin- releasing hormone may relate to the elevatory serum prolactin and amenorrhea. In addition, there are some suspicious factors, such as chest wall injury, pituitary body contusion, enkephalins increasing, the stimulation of spinal neural pathways, stress, and so on. Bromocriptine has been tried for it.

Key words: spinal cord injury, female, hyperprolactinemia, review