失神经性肌萎缩动物模型制备方法的研究进展

doi:10.3969/j.issn.1006-9771.2018.01.015

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (1): 80-83.doi: 10.3969/j.issn.1006-9771.2018.01.015

失神经性肌萎缩动物模型制备方法的研究进展

赵丹丹, 唐成林, 黄思琴, 罗翱, 张安宁, 安荟羽, 吴梦佳, 谭程方

1.重庆医科大学中医药学院,重庆市 400016
2.中医药防治代谢性疾病重庆市重点实验室,重庆市 400016

收稿日期:2017-09-25 修回日期:2017-11-25 出版日期:2018-01-25 发布日期:2018-01-31
通讯作者: 唐成林,男,汉族,教授,硕士生导师,主要研究方向：针灸推拿机制;E-mail:cytcl996@163.com。
作者简介:赵丹丹(1991-),女,汉族,山东淄博市人,硕士研究生,主要研究方向：针灸推拿机制。
基金资助:
国家自然科学基金项目(No.81273870)

Advance in Model Establishment for Denervated Skeletal Muscle Atrophy (review)

ZHAO Dan-dan, TANG Cheng-lin, HUANG Si-qin, LUO Ao, ZHANG An-ning, AN Hui-yu, WU Meng-jia, TAN Cheng-fang

1. College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China
2. Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing 400016, China

Received:2017-09-25 Revised:2017-11-25 Published:2018-01-25 Online:2018-01-31
Contact: TANG Cheng-lin.E-mail:cytcl996@163.com
Supported by:
National Natural Science Foundation of China (No. 81273870)

摘要/Abstract

摘要： 神经受损后,靶肌肉会不可避免地出现失神经性萎缩。按照神经损伤的来源,可将失神经性肌萎缩分为外源性失神经肌萎缩和内源性失神经肌萎缩。目前外源性失神经肌萎缩动物模型的制备方法主要包括手术制备、物理因素制备和化学因素制备,内源性失神经肌萎缩则多以肌萎缩侧索硬化症的转基因动物作为模型。选择和优化动物模型,使其更加契合临床的病理机制,是进行基础研究的关键。

关键词: 失神经性肌萎缩, 动物模型, 制作, 综述

Abstract: The skeletal muscle atrophy could be induced by the injury of nerve. According to the source of denervated skeletal muscle atrophy, it could be divided into exogenous muscle atrophy and endogenous muscle atrophy. In recent years, the exogenous muscle atrophy models are mainly established by operating, physically injuring or chemically injuring, while the endogenous muscle atrophy models are mainly established by the transgenic animals of amyotrophic lateral sclerosis. The selection and optimazation of animal models are crucial for the basic studies of denervated skeletal muscle atrophy.

Key words: denervated skeletal muscle atrophy, animal model, establishment, review

中图分类号:

R746.4

赵丹丹, 唐成林, 黄思琴, 罗翱, 张安宁, 安荟羽, 吴梦佳, 谭程方. 失神经性肌萎缩动物模型制备方法的研究进展[J]. 《中国康复理论与实践》, 2018, 24(1): 80-83.

ZHAO Dan-dan, TANG Cheng-lin, HUANG Si-qin, LUO Ao, ZHANG An-ning, AN Hui-yu, WU Meng-jia, TAN Cheng-fang. Advance in Model Establishment for Denervated Skeletal Muscle Atrophy (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(1): 80-83.

参考文献

[1] Lang F, Aravamudhan S, Nolte H, et al. Dynamic changes in the skeletal muscle proteome during denervation-induced atrophy [J]. Dis Model Mech, 2017, 10(7): 881-896.
[2] Agüera E, Castilla S, Luque E, et al. Denervated muscle extract promotes recovery of muscle atrophy through activation of satellite cells. An experimental study [J]. J Sport Health Sci, 2017. [Epub ahead of print]. doi:10.1016/j.jshs.2017.05.008.
[3] Zhou J, Liu B, Liang C, et al. Cytokine signaling in skeletal muscle wasting [J]. Trends Endocrinol Metab, 2016, 27(5): 335-347.
[4] Su Z, Hu L, Cheng J, et al. Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy [J]. J Appl Physiol, 2016, 120(4): 426-436.
[5] 郭汝宝,严隽陶,张喜林,等. 推拿手法对骨骼肌失神经后卫星细胞增殖与IGF-Ⅰ表达影响的实验研究[J]. 中华中医药学刊, 2013, 31(9): 1872-1874.
[6] Moresi V, Williams AH, Meadows E, et al. Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases [J]. Cell, 2010, 143(1): 35-45.
[7] Sunderland S. A classification of peripheral nerve injuries producing loss of function [J]. Brain, 1951, 74(4): 491-516.
[8] Huang QK, Qiao HY, Fu MH, et al. MiR-206 attenuates denervation-induced skeletal muscle atrophy in rats through regulation of satellite cell differentiation via TGF-β1, Smad3, and HDAC4 signaling [J]. Med Sci Monit, 2016, 22: 1161-1170.
[9] 韩利军,梁炳生,王乐,等. 失神经骨骼肌萎缩中泛素蛋白连接酶Murf1和核转录因子NF-κB表达与被动运动干预[J]. 中国组织工程研究与临床康复, 2010, 14(24): 4435-4438.
[10] 杨绍安,靳安民,蔡宝塔,等. 酸性成纤维细胞生长因子预防失神经支配肌运动终板退变及肌萎缩的实验研究[J]. 中华显微外科杂志, 2006, 29(3): 213-214.
[11] Wu R, Yan Y, Yao J, et al. Calpain 3 expression pattern during gastrocnemius muscle atrophy and regeneration following sciatic nerve injury in rats [J]. Int J Mol Sci, 2015, 16(11): 26927-26935.
[12] 周岚,吴颢昕,梅晓云. 补阳还五汤延缓大鼠胫前肌失神经肌萎缩的基因筛选[J]. 中草药, 2014, 45(4): 516-522.
[13] Gigo-Benato D, Russo TL, Geuna S, et al. Electrical stimulation impairs early functional recovery and accentuates skeletal muscle atrophy after sciatic nerve crush injury in rats [J]. Muscle Nerve, 2010, 41(5): 685-693.
[14] Pan F, Yu T, Wong S, et al. Chinese Tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats [J]. Chin J Integr Med, 2017, 23(8): 617-624.
[15] Chen XM, Xu J, Song JG, et al. Electroacupuncture inhibits excessive interferon-γ evoked up-regulation of P2X4 receptor in spinal microglia in a CCI rat model for neuropathic pain [J]. Br J Anaesth, 2014, 114(1): 150-157.
[16] 车光昇,郭源秩,宋光熠. 神经源性肌萎缩病理动物模型的制备[J]. 辽宁医学杂志, 2014, 28(5): 301.
[17] Zhang S, Tang H, Zhou J, et al. Electroacupuncture attenuates neuropathic pain after brachial plexus injury [J]. Neural Regen Res, 2014, 9(14): 1365-1370.
[18] 潘峰. 大鼠分娩性臂丛损伤模型肱二头肌与前肢爪内肌microRNA表达差异以及正常大鼠肱二头肌与前肢爪内肌神经肌肉接头出生后发育差异[D]. 上海:复旦大学, 2014.
[19] Wu Y, Collier L, Qin W, et al. Electrical stimulation modulates Wnt signaling and regulates genes for the motor endplate and calcium binding in muscle of rats with spinal cord transaction [J]. BMC Neurosci, 2013, 14(1): 81-95.
[20] Zhang YT, Jin H, Wang JH, et al. Tail nerve electrical stimulation and electro-acupuncture can protect spinal motor neurons and alleviate muscle atrophy after spinal cord transection in rats [J]. Neural Plast, 2017, 2017: 7351238.
[21] Wei ZJ, Zhou XH, Fan BY, et al. Proteomic and bioinformatic analyses of spinal cord injury induced skeletal muscle atrophy in rats [J]. Mol Med Rep, 2016, 14(1): 165-174.
[22] Bramlett HM, Dietrich WD, Marcillo A, et al. Effects of low intensity vibration on bone and muscle in rats with spinal cord injury [J]. Osteoporos Int, 2014, 25(9): 2209-2219.
[23] Romeo-Guitart D, Forés J, Navarro X, et al. Boosted regeneration and reduced denervated muscle atrophy by neuroheal in a pre-clinical model of lumbar root avulsion with delayed reimplantation [J]. Sci Rep, 2017, 7(1): 12028-12040.
[24] Tamaki H, Yotani K, Ogita F, et al. Electrical stimulation of denervated rat skeletal muscle ameliorates bone fragility and muscle loss in early-stage disuse musculoskeletal atrophy [J]. Calcif Tissue Int, 2017, 100(4): 420-430.
[25] 徐鹏,王涛,冯露,等. 高强度聚焦超声建立骨骼肌失神经萎缩动物模型的研究[J]. 重庆医科大学学报, 2010, 35(1): 48-50.
[26] Yu J, Wang M, Liu J, et al. Effect of electroacupuncture on the expression of agrin and acetylcholine receptor subtypes in rats with tibialis anterior muscular atrophy induced by sciatic nerve injection injury [J]. Acupunct Med, 2017, 35(4): 268-275.
[27] 刘焕彩,丁昊宇,王箐,等. Cyclin D1在肌萎缩侧索硬化症转基因小鼠大脑皮层和海马中的表达[J]. 神经解剖学杂志, 2017, 33(4): 423-429.
[28] Hwee DT, Kennedy A, Ryans J, et al. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model [J]. PLoS One, 2014, 9(5): e96921.
[29] Cai MD, Choi SM, Yang EJ. The effects of bee venom acupuncture on the central nervous system and muscle in an animal hSOD1G93A mutant [J]. Toxins, 2015, 7(3): 846-858.
[30] Shahidi B, Shah SB, Esparza M, et al. Skeletal muscle atrophy and degeneration in a mouse model of taumatic brain injury [J]. J Neurotrauma, 2017. [Epub ahead of print]. doi:10.1089/neu.2017.5172.
[31] Li TS, Shi H, Wang L, et al. Effect of bone marrow mesenchymal stem cells on satellite cell proliferation and apoptosis in immobilization-induced muscle atrophy in rats [J]. Med Sci Monit, 2016, 22: 4651-4660.
[32] 李洋. 不同配伍比例的黄芪当归药对对废用性肌萎缩的影响[D]. 西安:西北大学, 2015.
[33] Whitehead N, Kim M, Bible K, et al. Simvastatin improves physiological function and protects against muscle degeneration in MDX mice: A novel therapeutic approach for Duchenne muscular dystrophy [J]. Neuromuscul Disord, 2015, 41(112): 12864-12869.
[34] Kou X, Li J, Liu X, et al. Ampelopsin attenuates the atrophy of skeletal muscle from D-gal-induced aging rats through activating AMPK/SIRT1/PGC-1α signaling cascade [J]. Biomed Pharmacother, 2017, 90: 311-320.
[35] 翟玉莹,李青南,刘洋,等. 地塞米松诱导近交系和封闭群Wistar大鼠骨骼肌萎缩效应比较[J]. 中华骨质疏松和骨矿盐疾病杂志, 2017, 10(1): 58-65.
[36] Sun R, Zhang S, Hu W, et al. Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPβ-regulated atrogin1 expression in cancer cachexia [J]. Am J Physiol Cell Physiol, 2016, 311(1): C101-C115.
[37] El-Lithy GM, El-Bakly WM, Matboli M, et al. Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy [J]. Transl Res, 2016, 177: 85-97.
[38] Damatto RL, Martinez PF, Lima ARR, et al. Heart failure-induced skeletal myopathy in spontaneously hypertensive rats [J]. Int J Cardiol, 2013, 167(3): 698-703.
[39] Qi Y, Shang J, Ma L, et al. Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats [J]. Respir Res, 2014, 15(1): 156-165.
[40] Wang DT, Yang YJ, Huang RH, et al. Myostatin activates the ubiquitin-proteasome and autophagy-lysosome systems contributing to muscle wasting in chronic kidney disease [J]. Oxid Med Cell Longev, 2015, 2015: 684965.

失神经性肌萎缩动物模型制备方法的研究进展

Advance in Model Establishment for Denervated Skeletal Muscle Atrophy (review)

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