《中国康复理论与实践》

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (10): 1177-1182.doi: 10.3969/j.issn.1006-9771.2019.10.011

• 临床研究 • 上一篇    下一篇

丰富康复训练对脑卒中患者认知功能和血清精氨酸的影响

王鑫1, 周洪雨1, 金星1, 徐池1, 林春1, 刘佳雨2, 吴书画1   

  1. 1.扬州大学临床医学院康复医学科，江苏扬州市 225001;
    2.扬州大学护理学院，江苏扬州市 225001
  • 出版日期:2019-10-25 发布日期:2019-10-30
  • 通讯作者: 王鑫，E-mail: wx000805qm@yeah.net E-mail:wx000805qm@yeah.net
  • 作者简介:王鑫(1978-)，男，汉族，江苏扬州市人，博士，副主任医师，副教授，主要研究方向：神经康复、脑高级功能障碍康复。
  • 基金资助:
    1.江苏省自然科学基金项目(No. BK20171280)；2.江苏省青年医学人才项目(No. QNRC2016339)；3.江苏省高层次卫生人才“六个一工程”拔尖人才项目(No. LGY2017028)；4.中国博士后科学基金资助项目(No. 2017M621675)

Effects of Enriched Rehabilitation on Cognitive Function and Serum Arginine in Stroke Patients

WANG Xin1, ZHOU Hong-yu1, JIN Xing1, XU Chi1, LIN Chun1, LIU Jia-yu2, WU Shu-hua1   

  1. 1.Department of Rehabilitation, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China;
    2.College of Nursing, Yangzhou University, Yangzhou, Jiangsu 225001, China
  • Published:2019-10-25 Online:2019-10-30
  • Contact: WANG Xin, E-mail: wx000805qm@yeah.net E-mail:wx000805qm@yeah.net
  • Supported by:
    Supported by National Natural Science Foundation of Jiangsu Province (No. BK20171280), Young Medical Talents Project of Jiangsu Province (No. QNRC2016339), “Six One Project” Scientific Research Project for High-Level Health Talents of Jiangsu Province (No. LGY2017028) and China Postdoctoral Science Fund (No. 2017M621675)

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摘要： 目的 观测丰富康复训练对脑卒中患者认知功能和血清精氨酸的影响。 方法 2017年1月至2018年6月，将本科脑卒中患者40例随机分为传统组(n = 20)和丰富组(n = 20)。传统组给予传统认知功能障碍康复训练，丰富组给予丰富康复训练，每天1次，每周6 d，连续3个月。两组治疗前、治疗3个月后，采用蒙特利尔认知评估量表(MoCA)、数字广度测试和Stroop色词测验评价认知功能，并测量血清精氨酸和丙二醛水平。 结果 所有患者均完成实验。治疗前，两组MoCA评分、数字广度测试评分和Stroop色词测试评分，血清精氨酸和丙二醛水平均无显著性差异(t < 1.243, P > 0.05)。治疗3个月后，两组各指标均改善(t > 2.170, P < 0.05)，丰富组优于传统组(t > 2.278, P < 0.05)。 结论 丰富康复训练可以改善脑卒中后患者认知功能障碍，可能与其显著降低脑卒中后升高的血清精氨酸浓度，减少机体氧化损伤有关。

关键词: 脑卒中, 丰富康复训练, 认知功能障碍, 精氨酸, 氧化损伤

Abstract: Objective To observe the effects of enriched rehabilitation on cognitive function and serum arginine in stroke patients. Methods From January, 2017 to June, 2018, 40 patients in our department were randomly divided into conventional group (n = 20) and enriched group (n = 20). The conventional group received cognitive rehabilitation, and the enriched group received enriched rehabilitation, once a day, six times a week for three months. Before treatment and three months after treatment, the cognitive function was assessed with Montreal Cognitive Assessment (MoCA), Digit Span Test and Stroop Color Word Test, and the levels of serum arginine and malondialdehyde were detected. Results Finally, all the patients completed the experiment. There was no significant difference in the scores of MoCA, Digit Span Test and Stroop Color Word Test, and the level of serum arginine and malondialdehyde before treatment (t < 1.243, P > 0.05). Three months after treatment, all the above indexes improved (t > 2.170, P < 0.05), and were better in the enriched group than in the conventional group (t > 2.278, P < 0.05). Conclusion Enriched rehabilitation could improve the cognitive function of patients after stroke, which might be related to the significant reduction of the elevated serum arginine and reduction of oxidative damage after stroke.

Key words: stroke, enriched rehabilitation, cognitive dysfunction, arginine, oxidative damage

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