《中国康复理论与实践》 ›› 2024, Vol. 30 ›› Issue (12): 1420-1427.doi: 10.3969/j.issn.1006-9771.2024.12.007
何惠芳1,2, 龚翔2, 王喜荟2, 朱思思2, 沈滢1,2(
)
收稿日期:2024-10-23
修回日期:2024-11-04
出版日期:2024-12-25
发布日期:2024-12-30
通讯作者:
沈滢(1981-),女,汉族,江苏南京市人,博士,副教授,主任治疗师,硕士研究生导师,主要研究方向:脑功能成像和非侵入性脑调控在认知领域的研究及应用。E-mail: 作者简介:何惠芳(2002-),女,汉族,江西宜春市人,本科生。
基金资助:
HE Huifang1,2, GONG Xiang2, WANG Xihui2, ZHU Sisi2, SHEN Ying1,2(
)
Received:2024-10-23
Revised:2024-11-04
Published:2024-12-25
Online:2024-12-30
Contact:
SHEN Ying
E-mail:shenying@njmu.edu.cn
Supported by:摘要:
目的 分析经颅超声刺激(TUS)在神经康复中应用的发展现状、研究热点和发展趋势。
方法 检索自建库至2023年12月31日中国知网、万方数据库和Web of Science核心合集数据库中关于TUS在神经康复领域应用的相关文献。采用VOSviewer 1.6.20和CiteSpace 6.2.R1进行可视化分析。
结果 共纳入247篇文献,其中中文124篇,英文123篇,年发文量总体呈上升趋势。中国、美国、加拿大、法国和韩国为英文文献的高产国家。中文高频关键词包括经颅超声、神经调控、帕金森病、脑卒中、临床疗效;形成的关键词聚类包括经颅超声、神经调控、上肢功能和帕金森病;出现的突现词包括康复、神经功能、超声治疗、闭环控制、低强度。英文高频关键词包括聚焦超声、深部脑刺激、经颅磁刺激、血脑屏障、丘脑切开术;形成的关键词聚类涉及组织型纤溶酶原激活物、超声波成像、经颅磁刺激、丘脑切开术、超声;出现的突现词有特发性震颤、神经刺激、直流电刺激和经颅超声刺激。
结论 TUS在神经康复中应用的相关研究呈上升趋势,主要关注其在帕金森病、特发性震颤和缺血性脑卒中的有效性和安全性。未来研究需深入探讨TUS的机制,优化治疗方案,并促进个性化治疗的发展。
中图分类号:
何惠芳, 龚翔, 王喜荟, 朱思思, 沈滢. 经颅超声刺激在神经康复中应用的文献计量分析[J]. 《中国康复理论与实践》, 2024, 30(12): 1420-1427.
HE Huifang, GONG Xiang, WANG Xihui, ZHU Sisi, SHEN Ying. Application of transcranial ultrasound stimulation in neurorehabilitation: a bibliometric analysis[J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(12): 1420-1427.
表4
出现频次前10位的中英文关键词"
| 排名 | 中文文献 | 英文文献 | ||
|---|---|---|---|---|
| 关键词 | 频次 | 关键词 | 频次 | |
| 1 | 经颅超声 | 16 | focused ultrasound | |
| 2 | 神经调控 | 15 | deep brain stimulation | |
| 3 | 脑卒中 | 10 | stimulation | |
| 4 | 帕金森病 | 6 | transcranial magnetic stimulation | |
| 5 | 临床疗效 | 2 | brain stimulation | |
| 6 | 康复 | 2 | transcranial focused ultrasound | |
| 7 | 闭环控制 | 2 | blood brain barrier | |
| 8 | 光遗传学 | 2 | neuromodulation | |
| 9 | 超声治疗 | 2 | noninvasive brain stimulation | |
| 10 | 脑梗死 | 2 | thalamotomy | |
| [1] | OSADA T, KONISHI S. Noninvasive intervention by transcranial ultrasound stimulation: modulation of neural circuits and its clinical perspectives[J]. Psychiatry Clin Neurosci, 2024, 78(5): 273-281. |
| [2] | 吴毅. 经颅超声刺激在脑卒中后神经功能康复中的研究进展[J]. 中国康复医学杂志, 2024, 39(8): 1081-1083. |
| WU Y. Research progress on transcranial ultrasound stimulation in neurological rehabilitation after stroke[J]. Chin J Rehabil Med, 2024, 39(8): 1081-1083. | |
| [3] |
ROSSI S, ANTAL A, BESTMANN S, et al. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: expert guidelines[J]. Clin Neurophysiol, 2021, 132(1): 269-306.
doi: 10.1016/j.clinph.2020.10.003 pmid: 33243615 |
| [4] | SREERAJ V S, ARUMUGHAM S S, VENKATASUBRAMANIAN G. Clinical practice guidelines for the use of transcranial direct current stimulation in psychiatry[J]. Indian J Psychiatry, 2023, 65(2): 289-296. |
| [5] |
FOMENKO A, NEUDORFER C, DALLAPIAZZA R F, et al. Low-intensity ultrasound neuromodulation: an overview of mechanisms and emerging human applications[J]. Brain Stimul, 2018, 11(6): 1209-1217.
doi: S1935-861X(18)30296-1 pmid: 30166265 |
| [6] |
翟兆琳, 刘登堂. 经颅聚焦超声刺激治疗精神障碍的研究现状及展望[J]. 上海交通大学学报(医学版), 2021, 41(1): 95-98.
doi: 10.3969/j.issn.1674-8115.2021.01.017 |
| ZHAI Z L, LIU D T. Research status and prospect of transcranial focused ultrasound stimulation in treatment of psychiatric disorders[J]. J Shanghai Jiao Tong Univ (Med Sci), 2021, 41(1): 95-98. | |
| [7] | 王卫宁, 梁思捷, 朱玉连. 经颅超声在脑部疾病中的应用研究进展[J]. 中国康复医学杂志, 2021, 36(1): 109-113. |
| [8] | QIN P P, JIN M, XIA A W, et al. The effectiveness and safety of low-intensity transcranial ultrasound stimulation: a systematic review of human and animal studies[J]. Neurosci Biobehav Rev, 2024, 156: 105501. |
| [9] |
KRISHNA V, SAMMARTINO F, REZAI A. A review of the current therapies, challenges, and future directions of transcranial focused ultrasound technology: advances in diagnosis and treatment[J]. JAMA Neurol, 2018, 75(2): 246-254.
doi: 10.1001/jamaneurol.2017.3129 pmid: 29228074 |
| [10] | GLÄNZEL W, CZERWON H J. A new methodological approach to bibliographic coupling and its application to the national, regional and institutional level[J]. Scientometrics, 1996, 37(2): 195-221. |
| [11] |
HAMEROFF S, TRAKAS M, DUFFIELD C, et al. Transcranial ultrasound (TUS) effects on mental states: a pilot study[J]. Brain Stimul, 2013, 6(3): 409-415.
doi: 10.1016/j.brs.2012.05.002 pmid: 22664271 |
| [12] | SHEN Y, ZHONG J G, LAN W T, et al. Bibliometric study of neuroinflammation in autism spectrum disorder[J]. Front Psychiatry, 2023, 14: 1086068. |
| [13] | 袁毅, 陈玉东, 闫佳庆, 等. 经颅霍尔效应刺激作用下神经元系统放电节律的理论研究[J]. 中国生物医学工程学报, 2016, 35(2): 247-251. |
| YUAN Y, CHEN Y D, YAN J Q, et al. Theoretical study of firing rhythm of neuron system based on transcranial hall-effect stimulation[J]. Chin J Biomed Eng, 2016, 35(2): 247-251. | |
| [14] |
WATTIEZ N, CONSTANS C, DEFFIEUX T, et al. Transcranial ultrasonic stimulation modulates single-neuron discharge in macaques performing an antisaccade task[J]. Brain Stimul, 2017, 10(6): 1024-1031.
doi: S1935-861X(17)30847-1 pmid: 28789857 |
| [15] | VERHAGEN L, GALLEA C, FOLLONI D, et al. Offline impact of transcranial focused ultrasound on cortical activation in primates[J]. eLife, 2019, 8: e40541. |
| [16] |
LEGON W, SATO T F, OPITZ A, et al. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans[J]. Nat Neurosci, 2014, 17(2): 322-329.
doi: 10.1038/nn.3620 pmid: 24413698 |
| [17] |
LEGON W, BANSAL P, TYSHYNSKY R, et al. Transcranial focused ultrasound neuromodulation of the human primary motor cortex[J]. Sci Rep, 2018, 8(1): 10007.
doi: 10.1038/s41598-018-28320-1 pmid: 29968768 |
| [18] |
AI L, BANSAL P, MUELLER J K, et al. Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study[J]. BMC Neurosci, 2018, 19(1): 56.
doi: 10.1186/s12868-018-0456-6 pmid: 30217150 |
| [19] |
MUELLER J, LEGON W, OPITZ A, et al. Transcranial focused ultrasound modulates intrinsic and evoked EEG dynamics[J]. Brain Stimul, 2014, 7(6): 900-908.
doi: 10.1016/j.brs.2014.08.008 pmid: 25265863 |
| [20] |
LEGON W, ADAMS S, BANSAL P, et al. A retrospective qualitative report of symptoms and safety from transcranial focused ultrasound for neuromodulation in humans[J]. Sci Rep, 2020, 10(1): 5573.
doi: 10.1038/s41598-020-62265-8 pmid: 32221350 |
| [21] | DARMANI G, BERGMANN T O, BUTTS PAULY K, et al. Non-invasive transcranial ultrasound stimulation for neuromodulation[J]. Clin Neurophysiol, 2022, 135: 51-73. |
| [22] | GIBB W R, LEES A J. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease[J]. J Neurol Neurosurg Psychiatry, 1988, 51(6): 745-752. |
| [23] | 李春婵, 杨佳佳, 刘近贞, 等. 经颅超声在帕金森病治疗中的应用[J]. 生物化学与生物物理进展, 2023, 50(1): 25-37. |
| LI C C, YANG J J, LIU J Z, et al. The application of transcranial ultrasound in the treatment of Parkinson's disease[J]. Prog Biochem Biophys, 2023, 50(1): 25-37. | |
| [24] | MAGARA A, BÜHLER R, MOSER D, et al. First experience with MR-guided focused ultrasound in the treatment of Parkinson's disease[J]. J Ther Ultrasound, 2014, 2: 11. |
| [25] |
BOND A E, SHAH B B, HUSS D S, et al. Safety and efficacy of focused ultrasound thalamotomy for patients with medication-refractory, tremor-dominant Parkinson disease: a randomized clinical trial[J]. JAMA Neurol, 2017, 74(12): 1412-1418.
doi: 10.1001/jamaneurol.2017.3098 pmid: 29084313 |
| [26] |
ZAAROOR M, SINAI A, GOLDSHER D, et al. Magnetic resonance-guided focused ultrasound thalamotomy for tremor: a report of 30 Parkinson's disease and essential tremor cases[J]. J Neurosurg, 2018, 128(1): 202-210.
doi: 10.3171/2016.10.JNS16758 pmid: 28298022 |
| [27] | GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019[J]. Lancet Neurol, 2021, 20(10): 795-820. |
| [28] | GUO J, LO W L A, HU H, et al. Transcranial ultrasound stimulation applied in ischemic stroke rehabilitation: a review[J]. Front Neurosci, 2022, 16: 964060. |
| [29] | ZHU S, MENG B, JIANG J, et al. The updated role of transcranial ultrasound neuromodulation in ischemic stroke: from clinical and basic research[J]. Front Cell Neurosci, 2022, 16: 839023. |
| [30] | 刘婧, 刘子渤, 李红玲. 经颅超声刺激辅助缺血性脑卒中后康复训练的研究进展[J]. 中华物理医学与康复杂志, 2021, 43(3): 268-272. |
| [31] | ISHIBASHI T, AKIYAMA M, ONOUE H, et al. Can transcranial ultrasonication increase recanalization flow with tissue plasminogen activator[J]. Stroke, 2002, 33(5): 1399-1404. |
| [32] | 席悦, 郭方圆, 晏光林, 等. 经颅超声刺激对脑卒中患者上肢功能恢复及皮质兴奋性的影响[J]. 华西医学, 2023, 38(6): 828-834. |
| XI Y, GUO F Y, YAN G L, et al. Effect of transcranial ultrasound stimulation on upper limb function recovery and cortical excitability in patients with stroke[J]. West Chin Med J, 2023, 38(6): 828-834. | |
| [33] |
LEE W, CHUNG Y A, JUNG Y, et al. Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound[J]. BMC Neurosci, 2016, 17(1): 68.
pmid: 27784293 |
| [34] | LOUIS E D, FERREIRA J J. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor[J]. Mov Disord, 2010, 25(5): 534-541. |
| [35] |
BENABID A L, POLLAK P, GERVASON C, et al. Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus[J]. Lancet, 1991, 337(8738): 403-406.
doi: 10.1016/0140-6736(91)91175-t pmid: 1671433 |
| [36] | WINTERMARK M, DRUZGAL J, HUSS D S, et al. Imaging findings in MR imaging-guided focused ultrasound treatment for patients with essential tremor[J]. AJNR Am J Neuroradiol, 2014, 35(5): 891-896. |
| [37] | ELIAS W J, LIPSMAN N, ONDO W G, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor[J]. N Engl J Med, 2016, 375(8): 730-739. |
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