《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (02): 144-146.

• 基础研究 • 上一篇    下一篇

代谢综合征患者颈动脉内中膜厚度与PAI-1的关系

徐燕; 李永杰; 高旭光   

  1. 北京大学人民医院神经内科,北京市 100044
  • 收稿日期:2007-08-09 出版日期:2008-02-01 发布日期:2008-02-01

Relationship between Carotid Artery Intima-media Thickness and PAI-1 in Patients with Metabolic Syndrome

XU Yan, LI Yong-jie,GAO Xu-guang.   

  1. The Department of Neurology, Bejing University People's Hospital, Beijing 100044, China
  • Received:2007-08-09 Published:2008-02-01 Online:2008-02-01

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摘要： 目的观察代谢综合征(MS)患者颈动脉内中膜厚度(IMT)与血浆纤溶酶原激活物抑制物-1(PAI-1)的关系。方法根据NCEP-ATPⅢ的MS诊断标准,323例住院患者分为MS组(160例)和非MS组(163例),采用ELISA法测定血浆PAI-1水平,应用高频多普勒超声检测颈动脉IMT及颈动脉粥样硬化斑块。结果MS组的PAI-1水平为(30.52±11.02)ng/ml,颈动脉IMT为(0.92±0.21)mm,粥样斑块发生率为63.1%,而非MS组分别为(26.57±11.09)ng/ml、(0.86±0.20)mm和49.1%,两组间差异有显著性意义(P<0.05～0.01),其中颈动脉IMT及粥样斑块发生率随着MS诊断条件数的增加而逐渐增加,差异有显著性意义(P<0.05)。多元逐步回归分析显示,PAI-1与颈动脉IMT独立相关(标准化回归系数β=0.105,P<0.05)。结论MS患者易引起颈动脉粥样硬化,PAI-1可能与动脉粥样硬化密切相关。

关键词: 代谢综合征, 血浆纤溶酶原激活物抑制物-1, 内中膜厚度, 动脉粥样硬化

Abstract: Objective To investigate the relationship between carotid artery intima-media thickness and plasminogen activator inhibitor-1(PAI-1)in patients with metabolic syndrome(MS).Methods According to the definition of MS by NCEP-ATP Ⅲ,323 patients were divided into the MS group(160 cases)and without MS group(163 cases).The PAI-1 level was assayed by ELISA.The carotid artery intima-media thickness(IMT)and atherosclerotic plaque were measured by high-frequency Doppler ultrasound.Results The PAI-1 level,carotid IMT and incidence rate of plaque of the MS group were 30.52±11.02 ng/ml,0.92±0.21 mm and 63.1% respectively.Those of the without MS group were 26.57±11.09 ng/ml,0.86±0.20 mm and 49.1% respectively.There was a significant difference between two groups(P<0.05～0.01).Moreover,with the increasing of the number of MS components,the carotid artery intima-media thickness(IMT)and incidence rate of plaque were gradually increased(P<0.05).The stepwise regression analysis showed that PAI-1 was independently associated with the carotid IMT(standardized coefficients=0.105,P<0.05).Conclusion MS tends to cause carotid atherosclerosis,the increase of PAI-1 is possibly correlated with carotid artery atherosclerosis.

Key words: metabolic syndrome, plasminogen activator inhibitor-1(PAI-1), intima-media thickness, artery atherosclerosis