脊髓损伤后脑源性神经营养因子神经生物学效应的研究进展

doi:10.3969/j.issn.1006-9771.2018.02.008

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (2): 160-164.doi: 10.3969/j.issn.1006-9771.2018.02.008

脊髓损伤后脑源性神经营养因子神经生物学效应的研究进展

李向哲^{1, 2}, 王灿³, 吴勤峰^{1, 2}, 王彤⁴

1.苏州科技城医院康复医学中心,江苏苏州市 215153;
2.南京医科大学附属苏州医院康复医学中心,江苏苏州市 215153;
3.苏州市立医院儿童发展中心,江苏苏州市 215008;
4. 江苏省人民医院康复中心,江苏南京市 210029

收稿日期:2017-11-30 修回日期:2018-01-01 出版日期:2018-02-25 发布日期:2018-03-02
通讯作者: 吴勤峰。E-mail: wuqinfeng0911@163.com
作者简介:李向哲(1988-),男,汉族,河南汝阳县人,硕士,医师,主要研究方向：脊髓损伤。通讯作者：吴勤峰,男,汉族,博士,副教授,副主任医师,主要研究方向：骨科及神经损伤的康复与治疗。
基金资助:
1.国家自然科学基金面上项目(No. 81672258); 2.苏州科学技术局民生科技项目(No. SYS201785)

Neurobiological Effect of Brain-derived Neurotrophic Factor after Spinal Cord Injury (review)

LI Xiang-zhe^{1, 2}, WANG Can³, WU Qin-feng^{1, 2}, WANG Tong⁴

1. Rehabilitation Medicine Center of Suzhou Science & Technology Town Hospital, Suzhou, Jiangsu 215153, China;;
2. Rehabilitation Medicine Center of Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu 215153, China;
3. Children's Development Center of Suzhou Municipal Hospital, Suzhou, Jiangsu 215008, China;
4. Rehabilitation Center of Jiangsu Provincial People's Hospital, Nanjing, Jiangsu 210029, China

Received:2017-11-30 Revised:2018-01-01 Published:2018-02-25 Online:2018-03-02
Contact: WU Qin-feng. E-mail:wuqinfeng0911@163.com
Supported by:
; Supported by National Natural Science Foundation of China (General) (No. 81672258) and Livelihood Science and Technology Program of Suzhou Science and Technology Bureau (No. SYS201785)

摘要/Abstract

摘要： 脊髓损伤可导致不同程度的躯体及自主神经功能障碍,严重影响患者的生活质量。本文介绍脑源性神经营养因子(BDNF)对脊髓损伤后的功能恢复促进作用及神经生物学效应,包括神经保护、神经可塑性、神经炎症过程调节等;以及BDNF在脊髓损伤后的不良影响,如导致神经病理性疼痛和痉挛状态等。

关键词: 脊髓损伤, 脑源性神经营养因子, 神经修复, 痉挛, 神经病理性疼痛, 综述

Abstract: Spinal cord injury (SCI) can lead to varying degrees of somatic and autonomic dysfunction and seriously affect the quality of life of patients. The neurobiology and function promotion effects of brain-derived neurotrophic factor (BDNF) after SCI have been extensively studied, including neuroprotection, neuroplasticity and process regulation of neuroinflammation, etc., as well as functional recovery. However, the adverse effects of BDNF after SCI, such as neuropathic pain and spasticity, were also studied.

Key words: spinal cord injury, brain-derived neurotrophic factor, neural repair, spasticity, neuropathic pain, review

中图分类号:

R651.2

李向哲, 王灿, 吴勤峰, 王彤. 脊髓损伤后脑源性神经营养因子神经生物学效应的研究进展[J]. 《中国康复理论与实践》, 2018, 24(2): 160-164.

LI Xiang-zhe, WANG Can, WU Qin-feng, WANG Tong. Neurobiological Effect of Brain-derived Neurotrophic Factor after Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(2): 160-164.

参考文献

[1] World Health Organization.International Perspectives on Spinal Cord Injury [R]. Malta: World Health Organization. [2017-11-01]. International Perspectives on Spinal Cord Injury [R]. Malta: World Health Organization. [2017-11-01]. http://www.who.int/mediacentre/factsheets/fs384/en/
[2] Cohen S, Levimontalcini R, Hamburger V.A nerve growth-stimulating factor isolated from sarcomas 37 and 180[J]. Proc Natl Acad Sci, 1954, 40(10): 1014-1018.
[3] Barde YA, Edgar D, Thoenen H.Purification of a new neurotrophic factor from mammalian brain[J]. EMBO J, 1982, 1(5): 549-553.
[4] Weishaupt N, Blesch A, Fouad K.BDNF: The career of a multifaceted neurotrophin in spinal cord injury[J]. Exp Neurol, 2012, 238(2): 254-264.
[5] Afarid M, Torabinami M, Zare B.Neuroprotective and restorative effects of the brain-derived neurotrophic factor in retinal diseases[J]. J Neurol Sci, 2016, 363: 43-50.
[6] Garraway SM, Huie JR.Spinal plasticity and behavior: BDNF-induced neuromodulation in uninjured and injured spinal cord[J]. Neural Plast, 2016, 2016: 9857201.
[7] Cobianchi S, Arbat-Plana A, López-álvarez VM, et al. Neuroprotective effects of exercise treatments after injury: the dual role of neurotrophic factors[J]. Curr Neuropharmacol, 2017, 15(4): 495-518.
[8] 李向哲,王彤. 脑源性神经营养因子对脊髓损伤后痉挛影响的研究进展[J]. 中国康复医学杂志, 2016, 31(11): 1289-1292.
[9] Fu J, Wang H, Deng L, et al.Exercise training promotes functional recovery after spinal cord injury[J]. Neural Plast, 2016, 2016: 4039580.
[10] Gorski JA, Zeiler SR, Tamowski S, et al.Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites[J]. J Neurosci, 2003, 23(17): 6856-6865.
[11] Alonso-Vanegas MA, Fawcett JP, Causing CG, et al.Characterization of dopaminergic midbrain neurons in a DBH: BDNF transgenic mouse[J]. J Comp Neurol, 1999, 413(3): 449-462.
[12] Leech KA, Hornby TG.High-intensity locomotor exercise increases brain-derived neurotrophic factor in individuals with incomplete spinal cord injury[J]. J Neurotrauma, 2017, 34(6): 1240-1248.
[13] Anderson MA, Burda JE, Ren Y, et al.Astrocyte scar formation aids central nervous system axon regeneration[J]. Nature, 2016, 532(7598): 195-200.
[14] Wandell BA, Smirnakis SM.Plasticity and stability of visual field maps in adult primary visual cortex[J]. Nat Rev Neurosci, 2010, 10(12): 873-884.
[15] Orefice LL, Waterhouse EG, Partridge JG, et al.Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines[J]. J Neurosci, 2013, 33(28): 11618-11632.
[16] Pattwell SS, Bath KG, Perez-Castro R, et al.The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex[J]. J Neurosci, 2012, 32(7): 2410-2421.
[17] Grau JW, Huie JR, Lee KH, et al.Metaplasticity and behavior: how training and inflammation affect plastic potential within the spinal cord and recovery after injury[J]. Front Neural Circuits, 2014, 8(13): 100.
[18] Dorsey SG, Lovering RM, Renn CL, et al.Genetic deletion of trkB.T1 increases neuromuscular function[J]. Am J Physiol Cell Physiol, 2012, 302(1): C141-C153.
[19] Mitre M, Mariga A, Chao MV.Neurotrophin signalling: novel insights into mechanisms and pathophysiology[J]. Clin Sci, 2017, 131(1): 13-23.
[20] Shi J.Regulatory networks between neurotrophins and miRNAs in brain diseases and cancers[J]. Acta Pharmacol Sin, 2015, 36(2): 149-157.
[21] Sharma HS, Nyberg F, Westman J, et al.Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord: An immunohistochemical study in the rat[J]. Amino Acids, 1998, 14(1): 121-129.
[22] Joosten EA, Houweling DA.Local acute application of BDNF in the lesioned spinal cord anti-inflammatory and anti-oxidant effects[J]. Neuroreport, 2004, 15(7): 1163-1166.
[23] Calabrese F, Rossetti AC, Racagni G, et al.Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity[J]. Front Cell Neurosci, 2014, 8: 430.
[24] Leal G, Comprido D, Duarte CB.BDNF-induced local protein synthesis and synaptic plasticity[J]. Neuropharmacology, 2014, 76(C): 639-656.
[25] Ziemlińska E, Kügler S, Schachner M, et al.Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats[J]. PLoS One, 2014, 9(2): e88833.
[26] Ritfeld GJ, Patel A, Chou A, et al.The role of brain-derived neurotrophic factor in bone marrow stromal cell-mediated spinal cord repair[J]. Cell Transplant, 2015, 24(11): 2209-2220.
[27] 张鑫,李萌,陈银海,等. hADSCs移植联合运动训练对脊髓损伤大鼠运动功能的影响及其相关机制[J]. 中华神经医学杂志, 2014, 13(5): 472-477.
[28] Mantilla CB, Gransee HM, Zhan WZ, et al.Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury[J]. Exp Neurol, 2013, 247(3): 101-109.
[29] Watson N, Ji X, Yasuhara T, et al.No pain, no gain: lack of exercise obstructs neurogenesis[J]. Cell Transplant, 2015, 24(4): 591-597.
[30] 曹雅娜,王红星,王彤,等. 康复治疗对脊髓损伤后脊髓内脑源性神经营养因子表达的影响[J]. 中华物理医学与康复杂志, 2014, 36(4): 312-315.
[31] Tashiro S, Shinozaki M, Mukaino M, et al.BDNF induced by treadmill training contributes to the suppression of spasticity and allodynia after spinal cord injury via upregulation of KCC2[J]. Neurorehabil Neural Repair, 2015, 29(7): 677-689.
[32] Keefe KM, Sheikh IS, Smith GM.Targeting neurotrophins to specific populations of neurons: NGF, BDNF, and NT-3 and their relevance for treatment of spinal cord injury[J]. Int J Mol Sci, 2017, 18(3): e548.
[33] Merighi A, Salio C, Ghirri A, et al.BDNF as a pain modulator[J]. Prog Neurobiol, 2008, 85(3): 297-317.
[34] Smith PA.BDNF: No gain without pain?[J]. Neuroscience, 2014, 283(283): 107-123.
[35] Endo T, Ajiki T, Inoue H, et al.Early exercise in spinal cord injured rats induces allodynia through TrkB signaling[J]. Biochem Biophys Res Commun, 2009, 381(3): 339-344.
[36] Lang BC, Zhang Z, Lv LY, et al.OECs transplantation results in neuropathic pain associated with BDNF regulating ERK activity in rats following cord hemisection[J]. BMC Neurosci, 2013, 14(1): 1-10.
[37] Walters ET.Neuroinflammatory contributions to pain after SCI: roles for central glial mechanisms and nociceptor-mediated host defense[J]. Exp Neurol, 2014, 258: 48-61.
[38] Wu J, Renn CL, Faden AI, et al.TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways[J]. J Neurosci, 2013, 33(30): 12447-12463.
[39] Hutchinson KJ, Gómez Pinilla F, Crowe MJ, et al.Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats[J]. Brain, 2004, 127(6): 1403-1414.
[40] Hayashida K, Clayton BA, Johnson JE, et al.Brain-derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats[J]. Pain, 2008, 136(3): 348-355.
[41] Macias M, Syring MM, Crowe M, et al.Pain with no gain: allodynia following neural stem cell transplantation in spinal cord injury[J]. Exp Neurol, 2006, 201(2): 335-348.
[42] Yao Z, Sun X, Li P, et al.Neural stem cells transplantation alleviate the hyperalgesia of spinal cord injured (SCI) associated with down-regulation of BDNF[J]. Int J Clin Exp Med, 2015, 8(1): 404-412.
[43] Miles JL, Smith PH, Schonbein W.Descending command systems for the initiation of locomotion in mammals[J]. Brain Res Rev, 2008, 57(1): 183-191.
[44] Hultborn H, Denton ME, Wienecke J, et al.Variable amplification of synaptic input to cat spinal motoneurones by dendritic persistent inward current[J]. J Physiol, 2003, 552(Pt 3): 945-952.
[45] Boyce VS, Park J, Gage FH, et al.Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats[J]. Eur J Neurosci, 2012, 35(2): 221-232.
[46] Lu P, Blesch A, Graham L, et al.Motor axonal regeneration after partial and complete spinal cord transaction[J]. J Neurosci, 2012, 32(24): 8208-8218.
[47] Frias B, Santos J, Morgado M, et al.The role of brain-derived neurotrophic factor (BDNF) in the development of neurogenic detrusor overactivity (NDO)[J]. J Neurosci, 2015, 35(5): 2146-2160.
[48] Boulenguez P, Liabeuf S, Bos R, et al.Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury[J]. Nat Med, 2010, 16(3): 302-307.

脊髓损伤后脑源性神经营养因子神经生物学效应的研究进展

Neurobiological Effect of Brain-derived Neurotrophic Factor after Spinal Cord Injury (review)

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