牛痘疫苗接种家兔炎症皮肤提取物的临床应用进展

doi:10.3969/j.issn.1006-9771.2019.02.011

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (2): 192-195.doi: 10.3969/j.issn.1006-9771.2019.02.011

牛痘疫苗接种家兔炎症皮肤提取物的临床应用进展

陈明桧^1,2，胡朝英¹, 李林¹

1. 首都医科大学宣武医院药学部，北京市神经药物工程技术研究中心，北京市 100053
2. 多伦多大学医学部药理和毒理系，加拿大多伦多M5S 1A8

收稿日期:2018-08-30 修回日期:2018-10-22 出版日期:2019-02-25 发布日期:2019-04-01
通讯作者: 李林。E-mail： linlixw@126.com
作者简介:陈明桧(1998-)，女，汉族，北京市人，本科生，主要研究方向：神经药理学。
基金资助:
1.北京市博士后科研基金项目(No. 2018-ZZ-105)

Advance in Clinical Application of Neurotropin (review)

CHEN Ming-hui^{1, 2}, HU Chao-ying¹, LI Lin¹

1. Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing Engineering Research Center for Nerve System Drugs, Beijing 100053, China
2. Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto M5S 1A8, Canada

Received:2018-08-30 Revised:2018-10-22 Published:2019-02-25 Online:2019-04-01
Contact: LI Lin. E-mail: linlixw@126.com
Supported by:
Beijing Postdoctoral Research Fund (No. 2018-ZZ-105)

摘要/Abstract

摘要： 牛痘疫苗接种家兔炎症皮肤提取物(neurotropin, NTP)是一种非蛋白小分子生物制品，早期在临床上多应用在镇痛方面，近年来发现其在免疫调节和神经保护方面也有重要作用，被认为有扩大适应症的潜能。本文综述该药在治疗神经源性疼痛、恶性肿瘤和缺血性脑卒中等疾病中的临床应用及其在镇痛、神经保护和免疫调节等药理学作用机制方面的研究进展。

关键词: 牛痘疫苗接种家兔炎症皮肤提取物, 镇痛, 神经保护, 免疫调节, 神经源性疼痛, 恶性肿瘤, 缺血性脑卒中, 综述

Abstract: In the developed countries, long-term care insurance system is adopted to deal with the problem of long-term care for the elderly. The developed countries use long-term care assessment tools to assess the Objective needs of the elderly, and then adopt a hierarchical management system to achieve rational allocation of resources. The development of long-term care assessment tools in the developed countries is relatively mature. Long-term care assessment tools in the development countries not only assesse the activities of daily living of the elderly and cognitive ability, but also pay more attention to the assessment of medical care. Presently, China's mainland region is also doing long-term care insurance system pilot. The assessment tools of the pilot cities mainly assess activities of daily living, cognitive ability and social participation. As the first city to enter an aging population in China, Shanghai's assessment tool is more comprehensive, which not only includes activities of daily living, cognitive ability and social participation, but also includes medical care. In line with the national community-home care model, Shanghai has also increased home environmental assessment. Taiwan, combined with our cultural background on the basis of foreign assessment tools, pays more attention to the load of primary caregivers, so as to reduce the pressure of informal caregivers.

Key words: neurotropin, analgesia, neuroprotection, immunomodulation, neuropathic pain, malignant tumor, ischemic stroke, review

中图分类号:

R741.05

陈明桧, 胡朝英, 李林. 牛痘疫苗接种家兔炎症皮肤提取物的临床应用进展[J]. 《中国康复理论与实践》, 2019, 25(2): 192-195.

CHEN Ming-hui, HU Chao-ying, LI Lin. Advance in Clinical Application of Neurotropin (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(2): 192-195.

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牛痘疫苗接种家兔炎症皮肤提取物的临床应用进展

Advance in Clinical Application of Neurotropin (review)

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