Nogo-A对突触可塑性的调节及相关神经疾病

doi:10.3969/j.issn.1006-9771.2019.02.012

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (2): 196-200.doi: 10.3969/j.issn.1006-9771.2019.02.012

Nogo-A对突触可塑性的调节及相关神经疾病

何梅^{1,2^{, 毛敏¹, 赵国燕¹, 汤竣杰¹, 冯爽¹, 鲁秀敏¹, 王永堂²}}

1. 重庆理工大学药学与生物工程学院，重庆市 400054
2. 第三军医大学大坪医院野战外科研究所，创伤、烧伤与复合伤国家重点实验室，重庆市 400042

收稿日期:2018-10-01 修回日期:2018-10-18 出版日期:2019-02-25 发布日期:2019-04-01
通讯作者: 鲁秀敏、王永堂。E-mail: luxm@cqut.edu.cn (鲁秀敏)；wangytlu@163.com (王永堂)
作者简介:何梅(1991-)，女，汉族，重庆市人，硕士研究生，主要研究方向：微生物与生化药学。
基金资助:
1.国家自然科学基金项目(No. 81671903; No. 81772064; No. 81372040)；2.重庆市研究生科研创新项目(No. CYS18313)；3.重庆理工大学大学生创新训练计划项目(No. 2018CX035)；4.创伤、烧伤与复合伤国家重点实验室开放基金项目(No. SKLKF201706)

Synaptic Plasticity Regulation of Nogo-A and Development of Related Neurological Diseases (review)

HE Mei^{1, 2}, MAO Min¹, ZHAO Guo-yan¹, TANG Jun-jie¹, FENG Shuang¹, LU Xiu-min¹, WANG Yong-tang²

1. College of Pharmacy and Biological Engineering, Chongqing University of Technology, Chongqing 400054, China
2. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China

Received:2018-10-01 Revised:2018-10-18 Published:2019-02-25 Online:2019-04-01
Contact: LU Xiu-min, WANG Yong-tang. E-mail: luxm@cqut.edu.cn (LU Xiu-min)； wangytlu@163.com(WANG Yong-tang)
Supported by:
National Natural Science Foundation of China (No. 81671903; No. 81772064; No. 81372040),

摘要/Abstract

摘要： 轴突损伤往往导致成年哺乳动物中枢神经系统永久性缺损。作为轴突生长抑制剂，Nogo-A及其受体在中枢神经系统成熟神经元中参与对突触可塑性的调节作用，并与脊髓损伤、多发性硬化症、阿尔茨海默病及创伤后应激障碍等的发病有关。

关键词: Nogo-A, Nogo-A受体, 突触可塑性, 神经系统疾病, 综述

Abstract: Axonal damage leads to permanent defects in the adult mammals central nervous system. As an important axonal growth inhibitor, Nogo-A and its receptors involve in the regulation of synaptic plasticity in mature neurons of the central nervous system, and play a role in the related neurological diseases, such as spinal cord injury, multiple sclerosis, Alzheimer's disease and posttraumatic stress disorder.

Key words: Nogo-A, Nogo-A receptors, synaptic plasticity, nervous system disease, review

中图分类号:

R741.02

何梅, 毛敏, 赵国燕, 汤竣杰, 冯爽, 鲁秀敏, 王永堂. Nogo-A对突触可塑性的调节及相关神经疾病[J]. 《中国康复理论与实践》, 2019, 25(2): 196-200.

HE Mei, MAO Min, ZHAO Guo-yan, TANG Jun-jie, FENG Shuang, LU Xiu-min, WANG Yong-tang. Synaptic Plasticity Regulation of Nogo-A and Development of Related Neurological Diseases (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(2): 196-200.

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Nogo-A对突触可塑性的调节及相关神经疾病

Synaptic Plasticity Regulation of Nogo-A and Development of Related Neurological Diseases (review)

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