调控缺血性脑卒中小胶质细胞极化的药物研究进展

doi:10.3969/j.issn.1006-9771.2020.05.013

《中国康复理论与实践》 ›› 2020, Vol. 26 ›› Issue (5): 559-562.doi: 10.3969/j.issn.1006-9771.2020.05.013

调控缺血性脑卒中小胶质细胞极化的药物研究进展

邓杜萍¹,范金¹,谢晓龙¹,李凌鑫²()

1.成都中医药大学养生康复学院,四川成都市 610075
2.四川大学华西医院康复科,四川成都市 610041

收稿日期:2019-08-13 修回日期:2019-10-14 出版日期:2020-05-25 发布日期:2020-05-29
通讯作者: 李凌鑫 E-mail:lilingxin111@163.com
作者简介:邓杜萍(1991-),女,汉族,四川眉山市人,硕士研究生,主要研究方向：缺血性脑卒中康复治疗。
基金资助:
1.四川省科技厅支撑计划项目(2016SZ0039);2.四川省科技厅重点研发项目(18ZDYF2033)

Advances in Drugs for Microglia Polarization after Ischemic Stroke (review)

DENG Du-ping¹,FAN Jin¹,XIE Xiao-long¹,LI Ling-xin²()

1. College of Health Care and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China
2. Department of Rehabilitation, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

Received:2019-08-13 Revised:2019-10-14 Published:2020-05-25 Online:2020-05-29
Contact: LI Ling-xin E-mail:lilingxin111@163.com
Supported by:
Sichuan Science and Technology Department Support Plan(2016SZ0039);Sichuan Science and Technology Department Research and Development Key Project(18ZDYF2033)

摘要/Abstract

摘要：

缺血性脑卒中后,小胶质细胞被激活,表现为M1和M2两种极化表型,许多药物可以促进缺血性脑卒中后小胶质细胞由M1型向M2型转化,如芬戈莫德、3-正丁基苯酞及其衍生物、姜黄素、西地那非、Exendin-4、雷公藤红素、Omega-3多元不饱和脂肪酸、Malibatol A、红景天苷等。

关键词: 缺血性脑卒中, 小胶质细胞, 表型, 药物, 综述

Abstract:

Microglia cells are activated after ischemic stroke, and polarized phenotypes of M1 and M2. Some drugs, such as fingolimod, 3-N-butylphthalide, curcumin, sildenafil, exendin-4, celastrol, omega-3 fatty acids, malibatol A, salidroside, etc., can transfer the polarization from M1 to M2, and may benefit the outcome of ischemic stroke.

Key words: ischemic stroke, microglia, phenotype, drugs, review

中图分类号:

R743.32

邓杜萍,范金,谢晓龙,李凌鑫. 调控缺血性脑卒中小胶质细胞极化的药物研究进展[J]. 《中国康复理论与实践》, 2020, 26(5): 559-562.

DENG Du-ping,FAN Jin,XIE Xiao-long,LI Ling-xin. Advances in Drugs for Microglia Polarization after Ischemic Stroke (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(5): 559-562.

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调控缺血性脑卒中小胶质细胞极化的药物研究进展

Advances in Drugs for Microglia Polarization after Ischemic Stroke (review)

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