卒中后失语工作记忆的事件相关电位及时频特征

doi:10.3969/j.issn.1006-9771.2024.03.009

摘要/Abstract

摘要：

目的探索卒中后失语(PSA)工作记忆的任务态脑电特征。

方法 2020年9月至2021年2月，于北京中医药大学东直门医院招募PSA患者(PSA组)和健康受试者(HC组)各8例，采集脑电图和记忆量表数据，通过工作记忆任务态的脑电数据分析时域事件相关电位(ERP)和时频的脑电频段指标特点，与记忆量表中的各项目进行相关性分析。

结果最终纳入10例，每组5例。ERP分析发现前额区诱发N1和P2成分，顶枕区诱发P300成分。与HC组相比，PSA组在出现条件下，中央前额区N1和P2激活增强，右侧顶枕区P300活动降低(|t| > 2.193, P < 0.05)。与HC组相比，PSA组在未出现条件下右侧前额区、中央顶枕区θ频段能量降低，左侧顶枕区α1频段能量降低，左侧中央区γ频段能量增加(t > 2.398, P < 0.05)。相关性分析显示，γ频段的能量与听觉词语学习测验中的即刻回忆(r = 0.914, P = 0.030)、正确再认(r = 0.931, P = 0.022)和数字广度测验中的倒背(r = 0.924, P = 0.025)、顺背(r = 0.889, P = 0.044)呈强正相关。

结论视觉工作记忆任务可调动PSA患者记忆相关脑区代偿活动，可作为PSA工作记忆相关研究的评价客观指征。语言损伤与工作记忆之间存在密切联系。

关键词: 卒中后失语, 工作记忆, 脑电图, 事件相关电位, 视觉工作记忆任务, 特征

Abstract:

Objective To explore the task-state electroencephalogram (EEG) characteristics of working memory in patients with post-stroke aphasia (PSA).

Methods From September, 2020 to February, 2021, a total of eight patients with PSA (PSA group) and eight healthy adults (HC group) were recruited to collect EEG and memory scale data. The EEG data of working memory task-states were used to analyze the characteristics of the EEG frequency band indicators in time domain event-related potentials (ERP) and frequency; and the correlation with the items in the memory scale.

Results Finally, five patients and five controls were included. N1 and P2 components were induced in the frontal area, and P300 components were induced in the parieto-occipital area. Compared with HC group, the activation of N1 and P2 increased in central prefrontal region, while the activity of P300 decreased in the right parieto-occipital region in PSA group (|t| > 2.193, P < 0.05). The energy of theta band decreased in the right prefrontal region and the central parieto-occipital region, the energy of alpha1 band decreased in the left parieto-occipital region, and the energy of gamma band increased in the left central region (t > 2.398, P < 0.05). The energy of gamma band correlated with immediate recall (r = 0.914, P = 0.030) and correct recognition (r = 0.931, P = 0.022) of Auditory Verbal Learning Test, and inverting (r = 0.924, P = 0.025) and anterograde (r = 0.889, P = 0.044) of Digit Span Test.

Conclusion Visual working memory task can activate the compensatory processing activity of memory related brain regions after PSA, which can be used as an objective indication for the evaluation of PSA working memory related research. There is close relationship between language impairment and working memory.

Key words: post-stroke aphasia, working memory, electroencephalography, event-related potentials, visual working memory task, characteristics

中图分类号:

R743.3

黄幸, 常静玲, 张梓寒, 李颖. 卒中后失语工作记忆的事件相关电位及时频特征[J]. 《中国康复理论与实践》, 2024, 30(3): 316-325.

HUANG Xing, CHANG Jingling, ZHANG Zihan, LI Ying. Characteristics of event-related potential and frequency on working memory of post-stroke aphasia[J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(3): 316-325.

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组别	n	年龄/岁	受教育年限/年
HC组	5	55.20±17.24	13.00±3.00
PSA组	5	68.60±12.44	10.40±3.13
t值		0.196	-1.341
P值		0.644	0.217

分项	评分
即刻回忆	9.60±5.59
短延迟回忆	1.60±1.14
长延迟回忆	0.40±0.55
延迟回忆总分	2.00±1.22
正确再认	7.40±4.56
正确否认	7.00±4.06
再认总分	14.40±8.56
顺背	7.40±5.50
倒背	2.00±1.58