近10年非侵入性脑刺激治疗帕金森病的文献计量分析

doi:10.3969/j.issn.1006-9771.2024.06.006

摘要/Abstract

摘要：

目的分析近10年非侵入性脑刺激治疗帕金森病相关研究的现状、热点及前沿趋势。

方法检索2014年1月至2023年12月在Web of Science核心合集中关于非侵入性脑刺激治疗帕金森病的相关文献，采用CiteSpace 6.1.R3对作者、机构、国家和关键词等绘制知识图谱。

结果共纳入1 351篇文献，发文量总体呈上升趋势，美国、意大利和中国是高产国家，伦敦大学是发文量最多的机构，发文最多的作者是Alfredo Berardelli。热点关键词有深部脑刺激、运动皮质、基底神经节等，近两年出现的突现词有治疗、非侵入性脑刺激、辅助运动区和运动障碍等。

结论近10年非侵入性脑刺激治疗帕金森病的相关研究热点主要集中在非侵入性脑刺激对帕金森病运动皮质区的研究、非侵入性脑刺激与深部脑刺激、非侵入性脑刺激与脑电图和功能成像等非侵入性神经成像技术的联合应用。未来可进一步探究非侵入性脑刺激辅助运动区改善帕金森病患者运动障碍。

关键词: 帕金森病, 非侵入性脑刺激, 文献计量学

Abstract:

Objective To analyze the current status, hotspots and trends of researches related to non-invasive brain stimulation for Parkinson's disease in the last decade.

Methods Literature related to non-invasive brain stimulation for Parkinson's disease in the Web of Science Core Collection was searched from January, 2014, to December, 2023, and CiteSpace 6.1.R3 was used to draw a knowledge map of authors, institutions, countries and keywords.

Results A total of 1 351 papers were included, with a general upward trend in the number of publication, with the United States, Italy and China being the high-producing countries, and the University of London being the most prolific institution, with Alfredo Berardelli being the most prolific author. Hot keywords included deep brain stimulation, motor cortex and basal ganglia, and emergent words that have appeared in the last two years included therapy, non-invasive brain stimulation, supplementary motor areas and movement disorders.

Conclusion The research hotspots related to non-invasive brain stimulation for Parkinson's disease in the last decade mainly focus on the stimulation on motor cortical areas, the combined application of non-invasive brain stimulation and deep brain stimulation, and non-invasive brain stimulation and non-invasive neuroimaging techniques, such as electroencephalography and functional imaging. Non-invasive brain stimulation of supplementary motor areas can be further explored to improve movement disorders in Parkinson's disease patients in the future.

Key words: Parkinson's disease, non-invasive brain stimulation, bibliometrics

中图分类号:

R742.5

胥琪玲, 姜晓煜, 毕鸿雁. 近10年非侵入性脑刺激治疗帕金森病的文献计量分析[J]. 《中国康复理论与实践》, 2024, 30(6): 665-674.

XU Qiling, JIANG Xiaoyu, BI Hongyan. Non-invasive brain stimulation for Parkinson's disease in decade: a bibliometrics analysis[J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(6): 665-674.

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参考文献 47

[1]	DORSEY E R, SHERER T, OKUN M S, et al. The emerging evidence of the Parkinson pandemic[J]. J Parkinsons Dis, 2018, 8(s1): S3-S8.
[2]	HAYES M T. Parkinson's disease and Parkinsonism[J]. Am J Med, 2019, 132(7): 802-807. doi: S0002-9343(19)30235-9 pmid: 30890425
[3]	REICH S G, SAVITT J M. Parkinson's disease[J]. Med Clin North Am, 2019, 103(2): 337-350.
[4]	MADRID J, BENNINGER D H. Non-invasive brain stimulation for Parkinson's disease: clinical evidence, latest concepts and future goals: a systematic review[J]. J Neurosci Methods, 2021, 347: 108957.
[5]	TYSNES O B, STORSTEIN A. Epidemiology of Parkinson's disease[J]. J Neural Transm (Vienna), 2017, 124(8): 901-905.
[6]	ZHANG W, DENG B, XIE F, et al. Efficacy of repetitive transcranial magnetic stimulation in Parkinson's disease: a systematic review and meta-analysis of randomised controlled trials[J]. EClinicalMedicine, 2022, 52: 101589.
[7]	DE OLIVEIRA P C A, DE ARAúJO T A B, MACHADO D, et al. Transcranial direct current stimulation on Parkinson's disease: systematic review and meta-analysis[J]. Front Neurol, 2021, 12: 794784.
[8]	PFEIFER K J, COOK A J, YANKULOVA J K, et al. Clinical efficacy and dosing of vibrotactile coordinated reset stimulation in motor and non-motor symptoms of Parkinson's disease: a study protocol[J]. Front Neurol, 2021, 12: 758481.
[9]	LEE S, LIU A, MCKEOWN M J. Current perspectives on galvanic vestibular stimulation in the treatment of Parkinson's disease[J]. Expert Rev Neurother, 2021, 21(4): 405-418.
[10]	CHEN C M. CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature[J]. J Am Soc Inform Sci Tech, 2006, 57(3): 359-377.
[11]	陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能[J]. 科学学研究, 2015, 33(2): 242-253.
	CHEN Y, CHEN C M, LIU Z Y, et al. The methodology function of CiteSpace mapping knowledge domains[J]. Stud Sci Sci, 2015, 33(2): 242-253.
[12]	王素素, 李丽凤, 张一民. 运动干预老年人肌少症近10年研究进展及国际热点可视化分析[J]. 中国组织工程研究, 2022, 26(14): 2223-2230.
	WANG S S, LI L F, ZHANG Y M. Visualization analysis on research progress and hotspots of exercise therapy for sarcopenia in older adults in recent decade[J]. Chin J Tissue Engin Res, 2022, 26(14): 2223-2230.
[13]	张建伟, 吕韶钧, 马晶, 等. 近10年国内外心脏康复研究现状与热点可视化分析[J]. 中国循环杂志, 2020, 35(8): 808-814.
	ZHANG J W, LÜ S J, MA J, et al. Visualization and analysis of the current status and hotspots of cardiac rehabilitation research at home and abroad in the past 10 years[J]. Chin Circul J, 2020, 35(8): 808-814.
[14]	LI C, SUN M, TIAN S. Research hotspots and effectiveness of transcranial magnetic stimulation in pain: a bibliometric analysis[J]. Front Hum Neurosci, 2022, 16: 887246.
[15]	赵静, 刘小菠, 张月, 等. 基于CiteSpace软件对神经肌肉电刺激治疗作用、热点及发展趋势的可视化分析[J]. 中国组织工程研究, 2022, 26(8): 1234-1241.
	ZHAO J, LIU X B, ZHANG Y, et al. Visualization analysis of neuromuscular electrical stimulation therapy based on CiteSpace: therapeutic effects, hot spots, and developmental trends[J]. Chin J Tissue Engin Res, 2022, 26(8): 1234-1241.
[16]	ZHOU K, ZHOU Y, ZENG Y, et al. Research hotspots and global trends of transcranial direct current stimulation in stroke: a bibliometric analysis[J]. Neuropsychiatr Dis Treat, 2023, 19: 601-613.
[17]	LEFAUCHEUR J P, ANTAL A, AYACHE S S, et al. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)[J]. Clin Neurophys, 2017, 128(1): 56-92.
[18]	KOJOVIC M, KASSAVETIS P, BOLOGNA M, et al. Transcranial magnetic stimulation follow-up study in early Parkinson's disease: a decline in compensation with disease progression?[J]. Mov Disord, 2015, 30(8): 1098-1106.
[19]	CHOU Y H, HICKEY P T, SUNDMAN M, et al. Effects of repetitive transcranial magnetic stimulation on motor symptoms in Parkinson disease[J]. JAMA Neurol, 2015, 72(4): 432-440.
[20]	ROSSINI P M, BURKE D, CHEN R, et al. Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee[J]. Clin Neurophysiol, 2015, 126(6): 1071-1107.
[21]	LEFAUCHEUR J P, ANDRÉ-OBADIA N, ANTAL A, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)[J]. Clin Neurophysiol, 2014, 125(11): 2150-2206.
[22]	LEFAUCHEUR J P, ALEMAN A, BAEKEN C, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014-2018)[J]. Clin Neurophysiol, 2020, 131(2): 474-528.
[23]	DORUK D, GRAY Z, BRAVO G L, et al. Effects of tDCS on executive function in Parkinson's disease[J]. Neurosci Lett, 2014, 582: 27-31. doi: 10.1016/j.neulet.2014.08.043 pmid: 25179996
[24]	ZANJANI A, ZAKZANIS K K, DASKALAKIS Z J, et al. Repetitive transcranial magnetic stimulation of the primary motor cortex in the treatment of motor signs in Parkinson's disease: a quantitative review of the literature[J]. Mov Disord, 2015, 30(6): 750-758.
[25]	SHIROTA Y, OHTSU H, HAMADA M, et al. Supplementary motor area stimulation for Parkinson disease: a randomized controlled study[J]. Neurology, 2013, 80(15): 1400-1405. doi: 10.1212/WNL.0b013e31828c2f66 pmid: 23516319
[26]	CHEN R, BERARDELLI A, BHATTACHARYA A, et al. Clinical neurophysiology of Parkinson's disease and Parkinsonism[J]. Clin Neurophysiol Pract, 2022, 7: 201-227. doi: 10.1016/j.cnp.2022.06.002 pmid: 35899019
[27]	LEODORI G, DE BARTOLO M I, GUERRA A, et al. Motor cortical network excitability in Parkinson's disease[J]. Mov Disord, 2022, 37(4): 734-744.
[28]	石曼欣妤, 孟德涛, 方伯言. 帕金森病康复研究进展的可视化分析[J]. 中国康复理论与实践, 2022, 28(9): 1060-1064. doi: 10.3969/j.issn.1006-9771.2022.09.008
	SHI M X Y, MENG D T, FANG B Y. Advance in Parkinson's disease rehabilitation: a visualization analysis[J]. Chin J Rehabil Theory Pract, 2022, 28(9): 1060-1064.
[29]	LATTARI E, COSTA S S, CAMPOS C, et al. Can transcranial direct current stimulation on the dorsolateral prefrontal cortex improves balance and functional mobility in Parkinson's disease?[J]. Neurosci Lett, 2017, 636: 165-169. doi: S0304-3940(16)30861-8 pmid: 27838447
[30]	UNDERWOOD C F, PARR-BROWNLIE L C. Primary motor cortex in Parkinson's disease: Functional changes and opportunities for neurostimulation[J]. Neurobiol Dis, 2021, 147: 105159.
[31]	DAGAN M, HERMAN T, HARRISON R, et al. Multitarget transcranial direct current stimulation for freezing of gait in Parkinson's disease[J]. Movem Disord, 2018, 33(4): 642-646.
[32]	FRICKE C, DUESMANN C, WOOST T B, et al. Dual-site transcranial magnetic stimulation for the treatment of Parkinson's disease[J]. Front Neurol, 2019, 10: 174. doi: 10.3389/fneur.2019.00174 pmid: 30899243
[33]	DA SILVA MACHADO C B, DA SILVA L M, GONÇALVES A F, et al. Multisite non-invasive brain stimulation in Parkinson's disease: a scoping review[J]. NeuroRehabilitation, 2021, 49(4): 515-531.
[34]	CHEN K H S, CHEN R. Invasive and noninvasive brain stimulation in Parkinson's disease: clinical effects and future perspectives[J]. Clin Pharmacol Ther, 2019, 106(4): 763-775.
[35]	D'ONOFRIO V, MANZO N, GUERRA A, et al. Combining transcranial magnetic stimulation and deep brain stimulation: current knowledge, relevance and future perspectives[J]. Brain Sci, 2023, 13(2): 349.
[36]	UDUPA K, BAHL N, NI Z, et al. Cortical plasticity induction by pairing subthalamic nucleus deep-brain stimulation and primary motor cortical transcranial magnetic stimulation in Parkinson's disease[J]. J Neurosci, 2016, 36(2): 396-404. doi: 10.1523/JNEUROSCI.2499-15.2016 pmid: 26758832
[37]	CHENG B, ZHU T, ZHAO W, et al. Effect of theta burst stimulation-patterned rTMS on motor and nonmotor dysfunction of Parkinson's disease: a systematic review and meta analysis[J]. Front Neurol, 2021, 12: 762100.
[38]	HORN M A, GULBERTI A, GÜLKE E, et al. A New stimulation mode for deep brain stimulation in Parkinson's disease: theta burst stimulation[J]. Mov Disord, 2020, 35(8): 1471-1475.
[39]	PEI G, LIU X, HUANG Q, et al. Characterizing cortical responses to short-term multidisciplinary intensive rehabilitation treatment in patients with Parkinson's disease: a transcranial magnetic stimulation and electroencephalography study[J]. Front Aging Neurosci, 2022, 14: 1045073.
[40]	MAIDAN I, ZIFMAN N, HAUSDORFF J M, et al. A multimodal approach using TMS and EEG reveals neurophysiological changes in Parkinson's disease[J]. Parkinsonism Relat Disord, 2021, 89: 28-33.
[41]	CASAROTTO S, TURCO F, COMANDUCCI A, et al. Excitability of the supplementary motor area in Parkinson's disease depends on subcortical damage[J]. Brain Stimul, 2019, 12(1): 152-160. doi: S1935-861X(18)30359-0 pmid: 30416036
[42]	FORMAGGIO E, TONELLATO M, ANTONINI A, et al. Oscillatory EEG-TMS reactivity in Parkinson disease[J]. J Clin Neurophysiol, 2023, 40(3): 263-268.
[43]	CASULA E P, STAMPANONI BASSI M, PELLICCIARI M C, et al. Subthalamic stimulation and levodopa modulate cortical reactivity in Parkinson's patients[J]. Parkinsonism Relat Disord, 2017, 34: 31-37.
[44]	DAI G, WANG M, LI Y, et al. Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson's disease[J]. Front Aging Neurosci, 2022, 14: 948696.
[45]	LENCH D H, DEVRIES W, KEARNEY-RAMOS T E, et al. Paired inhibitory stimulation and gait training modulates supplemental motor area connectivity in freezing of gait[J]. Parkinsonism Relat Disord, 2021, 88: 28-33.
[46]	LOHSE A, MEDER D, NIELSEN S, et al. Low-frequency transcranial stimulation of pre-supplementary motor area alleviates levodopa-induced dyskinesia in Parkinson's disease: a randomized cross-over trial[J]. Brain Commun, 2020, 2(2): fcaa147.
[47]	SADLER C M, KAMI A T, NANTEL J, et al. Transcranial direct current stimulation of supplementary motor area improves upper limb kinematics in Parkinson's disease[J]. Clin Neurophysiol, 2021, 132(11): 2907-2915. doi: 10.1016/j.clinph.2021.06.031 pmid: 34412968

排名	国家/地区	发文量	中心性
1	美国	350	0.39
2	意大利	225	0.18
3	中国	188	0.01
4	英国	149	0.18
5	德国	133	0.22

排名	作者	被引频次	中心性
1	Jean-Pascal Lefaucheur	274	0.06
2	Felipe Fregni	224	0.02
3	David H Benninger	203	0.06
4	Michael A Nitsche	187	0.05
5	Robert Chen	183	0.26

排名	机构	发文量	中心性
1	University of London	74	0.13
2	University College London	59	0.11
3	Sapienza University Rome	58	0.06
4	University of Toronto	53	0.07
5	Harvard University	52	0.09

聚类号	Size	Silhouette	标签	LLR聚类关键词
#0	63	0.592	经颅直流电刺激	重复经颅磁刺激、背外侧前额叶、抑郁、深部脑刺激
#1	43	0.660	运动障碍	深部脑刺激、特发性震颤、磁共振成像、皮质靶向
#2	38	0.644	经颅磁刺激	皮质兴奋性、配对关联刺激、初级运动皮质、可塑性
#3	18	0.980	侧向准备电位	视觉诱发电位、触觉、脑肠轴、传入通路、传出通路
#4	15	0.903	基底神经节	丘脑底核、局部场电位、经颅磁刺激、抑郁
#5	12	0.997	TMS联合脑电图	重复经颅磁刺激、意识障碍、无动力缄默症、步态障碍
#6	12	0.939	帕金森病	深部脑刺激、功能性运动障碍、路易氏体、定量脑电图分析
#7	11	0.987	功能成像	补充运动区、θ爆发刺激、前运动皮质、研究间异质性
#8	9	1.000	神经性疼痛	脊髓电刺激、神经刺激疗法、经皮神经电刺激、深部脑刺激
#9	9	0.976	精神症状	帕金森病晚期、心理健康服务、抗抑郁药、营养和遗传因素
#10	9	0.989	非侵入性电刺激	内侧前额叶皮质、运动抑制、声遗传学、声全息透镜、嗅觉
#11	1	0.000	痴呆	情景记忆、灰质、弥散、神经心理状态
#12	1	0.000	动态平衡	平衡点、站立平衡、前庭电刺激、足底压力

排名	研究	频次	中心性
1	Lefaucheur等^[17](2017)	52	0.05
2	Rossini等^[20](2015)	52	0.03
3	Lefaucheur等^[21](2014)	50	0.05
4	Chou等^[19](2015)	48	0.11
5	Lefaucheur等^[22](2020)	43	0.08