经颅电刺激在阿尔茨海默病中应用的文献计量分析

doi:10.3969/j.issn.1006-9771.2026.07.009

《中国康复理论与实践》 ›› 2026, Vol. 32 ›› Issue (7): 817-828.doi: 10.3969/j.issn.1006-9771.2026.07.009

经颅电刺激在阿尔茨海默病中应用的文献计量分析

张仕坤¹, 张菡奚², 余一苇¹, 杨翼¹()

¹ 武汉体育学院研究生院，湖北武汉市 430079
² 浙江大学医学院附属第二医院，浙江杭州市 310052

收稿日期:2026-04-13 修回日期:2026-06-15 接受日期:2026-06-23 出版日期:2026-07-25 发布日期:2026-07-30
通讯作者: 杨翼，E-mail： yangyi999999@foxmail.com
作者简介:张仕坤(2003-)，男，汉族，四川绵阳市人，硕士研究生，主要研究方向：慢性疾病的临床与基础研究。
杨翼(1973-)，女，汉族，浙江余姚市人，教授，博士研究生导师，主要研究方向：体卫融合的临床与基础研究。
基金资助:
国家自然科学基金项目(81970261);湖北省自然科学基金创新发展联合基金项目(2026AFC1000)

Application of transcranial electrical stimulation in Alzheimer's disease: a bibliometric analysis

Zhang Shikun¹, Zhang Hanxi², Yu Yiwei¹, Yang Yi¹()

¹ Wuhan Sports University Graduate School, Wuhan, Hubei 430079, China
² The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China

Received:2026-04-13 Revised:2026-06-15 Accepted:2026-06-23 Published:2026-07-25 Online:2026-07-30
Supported by:
National Natural Science Foundation of China(81970261);Hubei Provincial Natural Science Foundation Innovation Development Joint Fund(2026AFC1000)

摘要/Abstract

摘要：

目的系统梳理经颅电刺激(tES)干预阿尔茨海默病(AD)领域文献，明晰该领域研究现状、核心热点和演化趋势。

方法检索Web of Science核心合集自建库至2026年3月收录的相关文献，采用VOSviewer、CiteSpace、Scimago Graphica和Bibliometrix R包开展文献计量与可视化分析。

结果最终纳入225篇文献；领域年度发文整体呈上升趋势，2019年后发文量明显增加，2025年发文量达峰值；中国总发文量60篇居首位，美国总被引频次和国际合作广度领先；哈佛大学、Alvaro Pascual-Leone分别为核心机构和核心作者，Journal of Alzheimer's Disease为发文最多期刊；高频关键词为阿尔茨海默病、经颅直流电刺激(tDCS)、记忆；当前研究聚焦不同tES模式、个体化靶点和参数优化。

结论 tES治疗AD领域处于高速发展阶段；现有研究以经颅直流电刺激临床疗效评估为主。

关键词: 阿尔茨海默病, 经颅电刺激, 文献计量学

Abstract:

Objective To systematically sort out literatures on transcranial electrical stimulation (tES) for Alzheimer's disease (AD), and clarify the research status, core hotspots and evolutionary trends in this field.

Methods Related literatures published from the inception of Web of Science Core Collection to March, 2026 were retrieved. Bibliometric and visual analyses were conducted via VOSviewer, CiteSpace, Scimago Graphica and Bibliometrix R package.

Results A total of 225 papers were included. The annual publication volume showed an overall upward trend with rapid growth after 2019 and a peak in 2025. China ranked first with 60 publications, while the United States gained the highest total citations and the broadest international collaborations. Harvard University and Alvaro Pascual-Leone were the leading institution and core author, respectively, and Journal of Alzheimer's Disease published the most relevant papers. High-frequency keywords included Alzheimer's disease, transcranial direct current stimulation (tDCS) and memory. Current researches mainly focused on various tES intervention modes, individualized stimulation targets and parameter optimization.

Conclusion Researches on tES for AD are developing rapidly, and mostly focus on clinical efficacy evaluation of transcranial direct current stimulation.

Key words: Alzheimer's disease, transcranial electrical stimulation, bibliometrics

中图分类号:

R749.1

张仕坤, 张菡奚, 余一苇, 杨翼. 经颅电刺激在阿尔茨海默病中应用的文献计量分析[J]. 《中国康复理论与实践》, 2026, 32(7): 817-828.

Zhang Shikun, Zhang Hanxi, Yu Yiwei, Yang Yi. Application of transcranial electrical stimulation in Alzheimer's disease: a bibliometric analysis[J]. Chinese Journal of Rehabilitation Theory and Practice, 2026, 32(7): 817-828.

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排名	国家	发文量/n	总被引次数
1	中国	60	1375
2	美国	55	2955
3	意大利	49	1884
4	西班牙	24	900
5	德国	20	1251

排名	机构	发文量/n	中心性
1	Harvard University	26	0.27
2	University of Toronto	15	0.11
3	Centre for Addiction & Mental Health-Canada	11	0.02
4	Massachusetts General Hospital	11	0.06
5	Beth Israel Deaconess Medical Center	10	0.22

排名	作者	发文量/n	总被引次数	H指数
1	Alvaro Pascual-Leone	13	1288	12
2	Maria Sofia Cotelli	10	649	9
3	Emiliano Santarnecchi	10	408	8
4	Tarek K Rajji	8	256	6
5	Alberto Benussi	7	292	5

排名	文献	被引频次
1	Fox等^[5](2014)	477
2	Floeel等^[6](2014)	320
3	Hsu等^[7](2015)	275
4	Boggio等^[8](2012)	220
5	Ladenbauer等^[9](2017)	173

排名	文献	共被引频次
1	Ferrucci等^[10](2008)	81
2	Boggio等^[8](2012)	74
3	Boggio等^[11](2009)	73
4	Khedr等^[12](2014)	69
5	Bystad等^[13](2016)	66

经颅电刺激在阿尔茨海默病中应用的文献计量分析

Application of transcranial electrical stimulation in Alzheimer's disease: a bibliometric analysis

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排名	关键词	频次
1	Alzheimer's disease	158
2	transcranial direct current stimulation	117
3	memory	94
4	noninvasive brain stimulation	71
5	mild cognitive impairment	68
6	transcranial magnetic stimulation	50
7	motor cortex	48
8	prefrontal cortex	39
9	dementia	33
10	transcranial alternating current stimulation	25

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