综述

小胶质细胞自噬在缺血性脑卒中中作用的研究进展

  • 王栋 ,
  • 侯博儒 ,
  • 杨文桢 ,
  • 康军林 ,
  • 任海军
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  • 兰州大学第二医院神经外科,甘肃兰州市 730000。
王栋(1989-),男,汉族,陕西西安市人,硕士研究生,主要研究方向:重型颅脑损伤及脑血管病。

收稿日期: 2016-09-09

  网络出版日期: 2017-01-15

基金资助

1.甘肃省自然科学基金面上基金项目(No. 1506RJZA222);2.兰州市科技局基金项目(No.2015-2-55)。

Role of Microglia Autophagy in Ischemic Stroke (review)

  • WANG Dong ,
  • HOU Bo-ru ,
  • YANG Wen-zhen ,
  • KANG Jun-lin ,
  • REN Hai-jun
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  • Department of Neurosurgery, Second Hospital Affiliated Lanzhou University, Lanzhou, Gansu 730000, China

Received date: 2016-09-09

  Online published: 2017-01-15

摘要

自噬在调控缺血性脑卒中后小胶质细胞活化及其介导的炎症反应中发挥重要作用。缺血性脑卒中后,小胶质细胞自噬与其介导神经炎症的相互作用具体调节机制十分复杂,涉及众多分子参与。小胶质细胞活化的受体及其相关物质可能是参与调控小胶质细胞自噬的潜在机制。自噬抑制剂和小胶质细胞受体靶向治疗可能会为临床治疗缺血性脑卒中提供新策略。本文就缺血性脑卒中后小胶质细胞自噬的相关研究进展进行综述。

本文引用格式

王栋 , 侯博儒 , 杨文桢 , 康军林 , 任海军 . 小胶质细胞自噬在缺血性脑卒中中作用的研究进展[J]. 中国康复理论与实践, 2016 , 22(12) : 1416 -1415 . DOI: 10.3969/j.issn.1006-9771.2016.12.011

Abstract

Autophagy plays an important role in the regulation of activation and inflammation of microglia after ischemic stroke. The interaction between autophagy of microglia and the inflammation mediated by microglia after ischemic stroke was complex and a large number of molecules were involved. The receptors of microglia activation and related substances may be possible mechanism in the regulation of microglia autophagy. Autophagy inhibitors and microglia receptor targeting therapy may provide new strategies for the clinical treatment of ischemic stroke. This paper summarized the progress of microglia autophagy after ischemic stroke.

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