《中国康复理论与实践》

中国康复理论与实践 >

2017 , Vol. 23 >Issue 5: 575 - 579

DOI: https://doi.org/10.3969/j.issn.1006-9771.2017.05.018

临床研究

海马亚区磁共振成像T2信号评估遗忘型轻度认知障碍的可行性

  • 张小洁 ,
  • 曹志宏 ,
  • 罗一烽 ,
  • 刘瑜 ,
  • 吴立伟 ,
  • 单海荣 ,
  • 刘怡文 ,
  • 李月峰 ,
  • 王冬青
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  • 1.江苏大学附属宜兴医院,a.神经内科;b.放射科,江苏无锡市 214200;
    2.宜兴市第二人民医院放射科,江苏无锡市 214200;
    3.江苏大学附属医院影像科,江苏镇江市 212000。
张小洁(1982-),女,汉族,江苏宜兴市人,硕士研究生,主治医师,主要研究方向：神经影像学。

收稿日期: 2016-06-23

  修回日期: 2016-07-19

  网络出版日期: 2017-05-24

基金资助

1.江苏省卫计委面上项目(No.H201656); 2.无锡市科技计划项目(No.CSZ0N1632; No.CSEW1N1111); 3.无锡市卫生计生科技成果和适宜技术推广项目(No.T201601); 4.无锡市卫计委科研项目(No.Z201610; No.ML201320)

收起

Application of Hippocampal Subfield Magnetic Resonance Imaging T2 Signal Intensity for Amnestic Mild Cognitive Impairment

  • ZHANG Xiao-jie ,
  • CAO Zhi-hong ,
  • LUO Yi-feng ,
  • LIU Yu ,
  • WU Li-wei ,
  • SHAN Hai-rong ,
  • LIU Yi-wen ,
  • LI Yue-feng ,
  • WANG Dong-qing
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  • 1. a. Department of Neurology; b. Department of Radiology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, Jiangsu 214200, China;
    2. Department of Radiology, the Yixing Second People's Hospital, Wuxi, Jiangsu 214200, China;
    3. Department of Radiology, the Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, China

Received date: 2016-06-23

  Revised date: 2016-07-19

  Online published: 2017-05-24

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摘要

目的 观察认知训练前后遗忘型轻度认知障碍(aMCI)患者海马亚区磁共振成像(MRI) T2信号的变化,为aMCI的临床早期诊疗提供影像学帮助。方法 2014年10月至2015年8月,aMCI患者40例随机均分为认知训练组和沟通组,另选老年健康志愿者20例作为对照组。认知训练组接受认知训练,沟通组采用普通谈话沟通,共治疗3个月。治疗前后采用快速自旋回波T2序列进行MRI检查,于工作站中勾画海马各亚区,测量T2信号强度,对T2信号强度与简易精神状态检查(MMSE)评分进行相关性分析。结果 治疗前,与对照组比较,认知训练组和沟通组双侧海马头部T2信号强度增高(P<0.05),认知训练组与沟通组之间无显著性差异(P>0.05)。治疗后,认知训练组左侧海马头部T2信号强度下降,与对照组无显著性差异(P>0.05),低于沟通组(P<0.05);认知训练组MMSE评分较治疗前升高(t=3.07, P<0.05)。治疗前后,认知训练组MMSE评分与左侧海马头部T2信号强度均呈负相关(r=-0.61, r=-0.54, P<0.05)。双侧体、尾部T2信号强度治疗前后各组间均无显著性差异(t<0.62, P>0.05)。结论 左侧海马头部MRI T2信号强度可反映aMCI颅内的病理生理改变,可用于评估认知训练效果,也可作为aMCI早期诊疗的辅助指标。

关键词： 轻度认知障碍; 海马; 磁共振成像; T2加权信号; 评定; 诊断

本文引用格式

张小洁 , 曹志宏 , 罗一烽 , 刘瑜 , 吴立伟 , 单海荣 , 刘怡文 , 李月峰 , 王冬青 . 海马亚区磁共振成像T2信号评估遗忘型轻度认知障碍的可行性[J]. 中国康复理论与实践, 2017 , 23(5) : 575 -579 . DOI: 10.3969/j.issn.1006-9771.2017.05.018

Abstract

Objective To apply the MRI T2 signal intensity of hippocampal subfield in patients with amnestic mild cognitive impairment (aMCI) as early imageology. Methods From October, 2014 to August, 2015, 20 aMCI patients accepted cognitive training (training group), 20 aMCI patients accepted speech communication (speech group), and 20 age- and gender-matched healthy old people (control group) were scanned with MRI using FSE-T2 sequence. The margin of hippocampal subfields were outlined manually for each side to measure the T2 signal intensity. The correlation between hippocampal T2 signal intensity and the scores of Mini-Mental State Examinatlon (MMSE) was analyzed in the training group. Results Before treatment, T2 signal intensity in the bilateral hippocampal head was significantly high in the aMCI patients compared with that in the control group (P<0.05). After treatment, T2 signal intensity in left hippocampal head decreased in the training group compared with that in the speech group (P<0.05), similar to the control group (P>0.05). There was negative correlation between left hippocampal head's T2 signal intensity and the scores of MMSE in the training group before and after treatment (r=-0.61, r=-0.54, P<0.05). Conclusion The T2 signal intensity in left hippocampal head may respond to the cognitive function in patients with aMCI in the early stage, that could be used for diagnosis and evaluation in clinic.

Key words： mild cognitive impairment; hippocampus; magnetic resonance imaging; T2-weighted signal; evaluation; diagnosis

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