吞咽障碍动物模型研究进展

doi:10.3969/j.issn.1006-9771.2020.00.018

《中国康复理论与实践》 ›› 2020, Vol. 26 ›› Issue (11): 1311-1315.doi: 10.3969/j.issn.1006-9771.2020.00.018

吞咽障碍动物模型研究进展

李斯锦¹,李彦杰²(),秦合伟²,金小琴¹,牛丽¹

1.河南中医药大学,河南郑州市 450046
2.河南省中医院,河南郑州市 450002

收稿日期:2020-03-22 修回日期:2020-06-29 出版日期:2020-11-25 发布日期:2020-11-24
通讯作者: 李彦杰 E-mail:690826500@qq.com
作者简介:李斯锦(1991-),女,汉族,河南驻马店市人,硕士研究生,主要研究方向：神经康复。|李彦杰(1969-),女,硕士,主任医师,主要研究方向：神经系统疾病的中西医康复。
基金资助:
1.国家自然科学基金委员会青年基金项目(81704030);2.河南省高等学校重点科研项目(19A360024);3.河南省中医药科学研究专项课题(2019ZYBJ14);4.河南省中医药文化与管理研究项目(TCM2019016);5.河南省中医药拔尖人才培养项目

Advance in Animal Models of Dysphagia (review)

LI Si-jin¹,LI Yan-jie²(),QIN He-wei²,JIN Xiao-qin¹,NIU Li¹

1. Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China
2. Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan 450002, China

Received:2020-03-22 Revised:2020-06-29 Published:2020-11-25 Online:2020-11-24
Contact: LI Yan-jie E-mail:690826500@qq.com
Supported by:
National Natural Science Foundation of China (Youth)(81704030);Henan Key Research Project for Colleges and Universities(19A360024);Henan Special Subject for Chinese Medicine Research(2019ZYBJ14);Henan Research Project for Culture and Management of Traditional Chinese Medicine(TCM2019016);Henan Traditional Chinese Medicine Top Talent Training Project

摘要/Abstract

摘要：

构建恰当的吞咽障碍动物模型,是进行吞咽障碍机制及治疗方法研究的重要手段。目前用于复制吞咽障碍的模型动物主要有啮齿动物、非人灵长类动物和其他一些哺乳动物,其中大、小鼠最为常用。复制的疾病模型主要有脑卒中后吞咽障碍、肌萎缩侧索硬化症吞咽障碍、帕金森病吞咽障碍以及口咽部神经肌肉病变吞咽障碍等类型。造模成功与否主要依靠吞咽功能评估,如透视荧光吞咽检查、电生理检查等。目前还没有动物模型能完整表现与人类相似的吞咽障碍临床和病理特征。随着定向遗传基因修饰等技术的发展,以及不同检测指标的联合使用,有望复制出更加合理的吞咽障碍模型。

关键词: 吞咽障碍, 动物模型, 吞咽, 综述

Abstract:

An appropriate animal model of dysphagia is important for research of the mechanism and treatment. Animal models of dysphagia mainly involve rodents, non-human primates and some other mammals, in which rats and mice are the most commonly used. The diseases mainly reproduced include stroke, amyotrophic lateral sclerosis, Parkinson's disease and oropharyngeal neuromuscular diseases, with dysphagia. The success of modeling mainly depends on the assessment of swallowing function, such as videofluoroscopic swallowing study and electrophysiological examination. No animal model can perfectly represent the clinical and pathological characteristics of dysphagia in humans now. With the development of targeted genetic modification and detection indicators, more reasonable dysphagia models would be reproduced.

Key words: dysphagia, animal model, swallow, review

中图分类号:

R493

李斯锦,李彦杰,秦合伟,金小琴,牛丽. 吞咽障碍动物模型研究进展[J]. 《中国康复理论与实践》, 2020, 26(11): 1311-1315.

LI Si-jin,LI Yan-jie,QIN He-wei,JIN Xiao-qin,NIU Li. Advance in Animal Models of Dysphagia (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(11): 1311-1315.

参考文献 48

[1]	窦祖林. 吞咽障碍评估与治疗[M]. 2版. 北京: 人民卫生出版社, 2017: 1-2.
	Dou Z L. Assessment and Treatment of Dysphagia[M]. 2nd ed. Beijing: People's Health Press, 2017: 1-2.
[2]	中国吞咽障碍康复评估与治疗专家共识组. 中国吞咽障碍评估与治疗专家共识(2017年版)第一部分评估篇[J]. 中华物理医学与康复杂志, 2017, 39(12):881-892.
	China Consensus Group on Rehabilitation Assessment and Treatment of Dysphagia. Consensus on Assessment and Treatment of Dysphagia in China (2017) Part I: Assessment[J]. Chin J Phys Med Rehabil, 2017, 39(12):881-892.
[3]	中国吞咽障碍康复评估与治疗专家共识组. 中国吞咽障碍评估与治疗专家共识(2017年版)第二部分治疗与康复管理篇[J]. 中华物理医学与康复杂志, 2018, 40(1):1-10.
	China Consensus Group on Rehabilitation Assessment and Treatment of Dysphagia. Consensus on Assessment and Treatment of Dysphagia in China (2017) Part II: Treatment and Rehabilitation[J]. Chin J Phys Med Rehabil, 2018, 40(1):1-10.
[4]	Sugiyama N, Nishiyama E, Nishikawa Y, et al. A novel animal model of dysphagia following stroke[J]. Dysphagia, 2014, 29(1):61-67. doi: 10.1007/s00455-013-9481-x pmid: 23907747
[5]	Tsuruta T, Sakai K, Watanabe J, et al. Dental pulp-derived stem cell conditioned medium to regenerate peripheral nerves in a novel animal model of dysphagia[J]. PLoS One, 2018, 13(12):36-38.
[6]	Cullins M J, Connor N P. Reduced tongue force and functional swallowing changes in a rat model of post stroke dysphagia[J]. Brain Res, 2019, 17(1):160-166.
[7]	Lever T E, Braun S M, Brooks R T, et al. Adapting human videofluoroscopic swallow study methods to detect and characterize dysphagia in murine disease models[J]. J Vis Exp, 2015, 12(97):52-53.
[8]	Hinkel C J, Sharma R, Thakkar M M, et al. Neural mechanisms contributing to dysphagia in mouse models[J]. Otolaryngol Head Neck Surg, 2016, 155(2):303-306. doi: 10.1177/0194599816640261
[9]	Nakamura Y, Iriarte-Diaz J, Arce-McShane F, et al. Sagittal plane kinematics of the jaw and hyolingual apparatus during swallowing in Macaca mulatta[J]. Dysphagia, 2017, 32(5):663-677. doi: 10.1007/s00455-017-9812-4 pmid: 28528492
[10]	Best M D, Nakamura Y, Kijak N A, et al. Semiautomatic marker tracking of tongue positions captured by videofluoroscopy during primate feeding[J]. Conf Proc IEEE Eng Med Biol Soc, 2015, 2015:5347-5350.
[11]	Vinyard C J, Wall C E, Williams S H, et al. Masseter electromyography during chewing in ring-tailed lemurs (Lemur catta)[J]. Am J Phys Anthropol, 2006, 130(1):85-95. doi: 10.1002/(ISSN)1096-8644
[12]	Arce-McShane F I, Hatsopoulos N G, Lee J C, et al. Modulation dynamics in the orofacial sensorimotor cortex during motor skill acquisition[J]. J Neurosci, 2014, 34(17):5985-5997. doi: 10.1523/JNEUROSCI.4367-13.2014
[13]	Arce F I, Lee J C, Ross C F, et al. Directional information from neuronal ensembles in the primate orofacial sensorimotor cortex[J]. J Neurophysiol, 2013, 110(6):1357-1369. doi: 10.1152/jn.00144.2013 pmid: 23785133
[14]	Ding P, Fung G S, Lin M, et al. The effect of bilateral superior laryngeal nerve lesion on swallowing: a novel method to quantitate aspirated volume and pharyngeal threshold in videofluoroscopy[J]. Dysphagia, 2015, 30(1):47-56. doi: 10.1007/s00455-014-9572-3
[15]	Gross A, Ohlemacher J, German R, et al. LVC timing in infant pig swallowing and the effect of safe swallowing[J]. Dysphagia, 2018, 33(1):51-62. doi: 10.1007/s00455-017-9832-0
[16]	Gould F D H, Yglesias B, Ohlemacher J, et al. Pre-pharyngeal swallow effects of recurrent laryngeal nerve lesion on Bolus shape and airway protection in an infant pig model[J]. Dysphagia, 2017, 32(3):362-373. doi: 10.1007/s00455-016-9762-2
[17]	Ballester A, Gould F, Bond L, et al. Maturation of the coordination between respiration and deglutition with and without recurrent laryngeal nerve lesion in an animal model[J]. Dysphagia, 2018, 33(5):627-635. doi: 10.1007/s00455-018-9881-z pmid: 29476275
[18]	Holman S D, Campbell-Malone R, Ding P, et al. Swallowing kinematics and airway protection after palatal local anesthesia in infant pigs[J]. Laryngoscope, 2014, 124(2):436-445. doi: 10.1002/lary.v124.2
[19]	Marks S L, Douthitt K L, Belafsky P C. Feasibility of flexible endoscopic evaluation of swallowing in healthy dogs[J]. Am J Vet Res, 2016, 77(3):294-299. doi: 10.2460/ajvr.77.3.294
[20]	Park A M, Bhatt N K, Paniello R C. Paclitaxel inhibits post-traumatic recurrent laryngeal nerve regeneration into the posterior cricoarytenoid muscle in a canine model[J]. Laryngoscope, 2017, 127(3):651-655. doi: 10.1002/lary.26058
[21]	Suzuki T, Yoshihara M, Sakai S, et al. Effect of peripherally and cortically evoked swallows on jaw reflex responses in anesthetized rabbits[J]. Brain Res, 2018, 169(4):19-28.
[22]	Yamada A, Kajii Y, Sakai S, et al. Effects of chewing and swallowing behavior on jaw opening reflex responses in freely feeding rabbits[J]. Neurosci Lett, 2013, 53(5):73-77.
[23]	Spearman D G, Poliacek I, Rose M J, et al. Variability of the pharyngeal phase of swallow in the cat[J]. PLoS One, 2014, 9(8):10-16.
[24]	Pitts T, Rose M J, Poliacek I, et al. Effect of laparotomy on the swallow-breathing relationship in the cat[J]. Lung, 2015, 193(1):129-133. doi: 10.1007/s00408-014-9662-x
[25]	Restivo D A, Hamdy S. Pharyngeal electrical stimulation device for the treatment of neurogenic dysphagia: technology update[J]. Med Devices (Auckl), 2018, 11(2):21-26.
[26]	袁清洁, 冯学功, 刘建勋, 等. 通咽喷雾剂对短暂性大脑中动脉栓塞大鼠吞咽功能和肺组织炎症的影响[J]. 中医杂志, 2019, 20(1):1766-1771.
	Yuan Q J, Feng X G, Liu J X, et al. Effects of Tongyan Spray on swallowing function and pulmonary inflammation in rats with transient middle cerebral artery occlusion[J]. J Trad Chin Med, 2019, 60(20):1766-1771.
[27]	Gulyaeva N, Thompson C, Shinohara N, et al. Tongue protrusion: a simple test for neurological recovery in rats following focal cerebral ischemia[J]. J Neurosci Methods, 2003, 125(1-2):183-193. doi: 10.1016/S0165-0270(03)00056-6
[28]	Ikeda J, Kojima N, Saeki K, et al. Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia[J]. Eur J Pharmacol, 2015, 74(6):126-131.
[29]	Zhang N, Miyamoto N, Tanaka R, et al. Activation of tyrosine hydroxylase prevents pneumonia in a rat chronic cerebral hypoperfusion model[J]. Neuroscience, 2009, 158(2):665-672. doi: 10.1016/j.neuroscience.2008.10.049 pmid: 19032975
[30]	Lever T E, Gorsek A, Cox K T, et al. An animal model of oral dysphagia in amyotrophic lateral sclerosis[J]. Dysphagia, 2009, 24(2):180-195. doi: 10.1007/s00455-008-9190-z
[31]	Lever T E, Simon E, Cox K T, et al. A mouse model of pharyngeal dysphagia in amyotrophic lateral sclerosis[J]. Dysphagia, 2010, 25(2):112-126. doi: 10.1007/s00455-009-9232-1
[32]	Osman K L, Kohlberg S, Mok A, et al. Optimizing the translational value of mouse models of ALS for dysphagia therapeutic discovery[J]. Dysphagia, 2019, 24(3):52-61.
[33]	Ciucci M R, Russell J A, Schaser A J, et al. Tongue force and timing deficits in a rat model of Parkinson disease[J]. Behav Brain Res, 2011, 222(2):315-320. doi: 10.1016/j.bbr.2011.03.057
[34]	Ciucci M R, Schaser A J, Russell J A. Exercise-induced rescue of tongue function without striatal dopamine sparing in a rat neurotoxin model of Parkinson disease[J]. Behav Brain Res, 2013, 25(2):239-245.
[35]	Russell J A, Ciucci M R, Hammer M J, et al. Videofluorographic assessment of deglutitive behaviors in a rat model of aging and Parkinson disease[J]. Dysphagia, 2013, 28(1):95-104. doi: 10.1007/s00455-012-9417-x pmid: 22763806
[36]	Kelm-Nelson C A, Stevenson S A, Ciucci M R. Data in support of qPCR primer design and verification in a Pink1 -/- rat model of Parkinson disease[J]. Data Brief, 2016, 18(2):360-363. doi: 10.1016/j.dib.2018.03.052
[37]	Desombres A C, Duclos C, Ghannouchi I, et al. Effect of liquid properties on swallowing and ventilation coordination in rats[J]. Neurogastroenterol Motil, 2017, 29(11):110-120.
[38]	Gould F D, Lammers A R, Ohlemacher J, et al. The physiologic impact of unilateral recurrent laryngeal nerve (RLN) lesion on infant oropharyngeal and esophageal performance[J]. Dysphagia, 2015, 30(6):714-722. doi: 10.1007/s00455-015-9648-8
[39]	Park A M, Bhatt N K, Paniello R C. Paclitaxel inhibits post-traumatic recurrent laryngeal nerve regeneration into the posterior cricoarytenoid muscle in a canine model[J]. Laryngoscope, 2017, 127(3):651-655. doi: 10.1002/lary.26058
[40]	Morishima Y, Chida K, Watanabe H. Estimation of the dose of radiation received by patient and physician during a videofluoroscopic swallowing study[J]. Dysphagia, 2016, 31(4):574-578. doi: 10.1007/s00455-016-9718-6 pmid: 27318941
[41]	Lever T E, Braun S M, Brooks R T, et al. Adapting human videofluoroscopic swallow study methods to detect and characterize dysphagia in murine disease models[J]. J Vis Exp, 2015, 97(2):52-59.
[42]	Inokuchi H, González-Fernández M, Matsuo K, et al. Electromyography of swallowing with fine wire intramuscular electrodes in healthy human: amplitude difference of selected hyoid muscles[J]. Dysphagia, 2016, 31(1):33-40. doi: 10.1007/s00455-015-9655-9 pmid: 26487062
[43]	Lang I M, Medda B K, Shaker R. Effects of esophageal acidification on esophageal reflexes controlling the upper esophageal sphincter[J]. Am J Physiol Gastrointest Liver Physiol, 2019, 316(1):45-54.
[44]	DeLozier K R, Gould F D H, Ohlemacher J, et al. Impact of recurrent laryngeal nerve lesion on oropharyngeal muscle activity and sensorimotor integration in an infant pig model[J]. J Appl Physiol, 2018, 125(1): 159‐166. doi: 10.1152/japplphysiol.00963.2017
[45]	Tsujimura T, Suzuki T, Yoshihara M, et al. Involvement of hypoglossal and recurrent laryngeal nerves on swallowing pressure[J]. J Appl Physiol, 2018, 124(5):1148-1154. doi: 10.1152/japplphysiol.00944.2017 pmid: 29357492
[46]	Tsuji K, Tsujimura T, Magara J, et al. Changes in the frequency of swallowing during electrical stimulation of superior laryngeal nerve in rats[J]. Brain Res Bull, 2015, 11(1):53-61.
[47]	Satoh Y, Tsuji K, Tsujimura T, et al. Suppression of the swallowing reflex by stimulation of the red nucleus[J]. Brain Res Bull, 2015, 11(6):25-33. doi: 10.1016/0361-9230(83)90053-9
[48]	Tsujimura T, Tsuji K, Ariyasinghe S, et al. Differential involvement of two cortical masticatory areas in modulation of the swallowing reflex in rats[J]. Neurosci Lett, 2012, 528(2):159-164. doi: 10.1016/j.neulet.2012.09.005 pmid: 22982202

吞咽障碍动物模型研究进展

Advance in Animal Models of Dysphagia (review)

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