穴位埋线对局灶性脑缺血再灌注损伤大鼠运动功能的影响

doi:10.3969/j.issn.1006-9771.2020.10.008

《中国康复理论与实践》 ›› 2020, Vol. 26 ›› Issue (10): 1167-1175.doi: 10.3969/j.issn.1006-9771.2020.10.008

穴位埋线对局灶性脑缺血再灌注损伤大鼠运动功能的影响

黄琴¹,周立志¹,谭彩玲¹,郑苏¹,彭力²()

1.湖北医药学院附属医院（十堰市太和医院）中医康复综合部,湖北十堰市 442000
2.十堰市中医医院,湖北十堰市 442000

收稿日期:2019-12-19 修回日期:2020-03-15 出版日期:2020-10-25 发布日期:2020-10-29
通讯作者: 彭力 E-mail:397966687@qq.com
作者简介:黄琴(1994-),女,汉族,湖北十堰市人,硕士研究生,主要研究方向：脑血管疾病康复治疗机理研究。
基金资助:
湖北省中医药科研项目(重点项目)(ZY2019Z012)

Effects of Acupoint Catgut Embedding on Motor Function in Cerebral Ischemia-reperfusion Injury in Rats

HUANG Qin¹,ZHOU Li-zhi¹,TAN Cai-ling¹,ZHENG Su¹,PENG Li²()

1. Comprehensive Department of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Medicine (Taihe Hospital), Shiyan, Hubei 442000, China
2. Shiyan Hospital of Traditional Chinese Medicine, Shiyan, Hubei 442000, China

Received:2019-12-19 Revised:2020-03-15 Published:2020-10-25 Online:2020-10-29
Contact: PENG Li E-mail:397966687@qq.com
Supported by:
Hubei Traditional Chinese Medicine Program (Key)(ZY2019Z012)

摘要/Abstract

摘要：

目的研究穴位埋线对局灶性脑缺血再灌注大鼠运动功能的影响,并探讨其可能作用机制。
方法取3月龄健康雄性SPF级Sprague-Dawley大鼠48只,随机分为3组,每组16只。假手术组仅离断右侧颈外动脉,模型组和穴位埋线组制作局灶性脑缺血90 min再灌注大鼠模型,穴位埋线组缺血再灌注90 min后于百会穴、右侧顶颞前斜线进行穴位埋线。再灌注1 d、3 d、7 d、14 d后,进行神经功能评分和网屏实验;再灌注14 d后,TTC染色比较各组脑梗死体积;HE染色观察神经细胞损伤;免疫组织化学、Western blotting和逆转录实时定量聚合酶链反应(RT-qPCR)检测缺血半暗带脑组织内胶质纤维酸性蛋白(GFAP)、突触素I的表达。
结果与假手术组相比,模型组神经功能评分显著降低(t > 11.851, P < 0.001),网屏实验时间显著缩短( t > 6.190, P < 0.001),GFAP阳性表达增加( P < 0.05),突触素I阳性表达下降( P < 0.05);与模型组比较,穴位埋线组神经功能评分显著增加( t > 3.464, P < 0.001),网屏实验时间显著增加( t > 3.642, P < 0.001),脑梗死体积显著减小( F = 93.426, P < 0.001),GFAP阳性表达降低( P < 0.05),突触素I阳性表达增加( P < 0.05)。
结论穴位埋线可促进局灶性脑缺血再灌注损伤大鼠运动功能恢复,可能与抑制星形胶质细胞反应性增生,增加缺血半暗带内轴突的再生,加强突触间连接与传导有关。

关键词: 缺血再灌注损伤, 穴位埋线, 运动功能, 突触重塑, 大鼠

Abstract:

Objectives To investigate the effect of acupoint catgut embedding on motor function of rats with cerebral ischemia-reperfusion, and explore its possible mechanism.
Methods A total of 48 three-month old healthy specified pathogen free male Sprague-Dawley rats were randomly divided into three groups with 16 rats in each group. The right external carotid artery was severed only in sham operation group. Right middle cerebral artery occlusion was induced for 90 minutes under isoflurane anesthesia using a monofilament in model group and acupoint catgut embedding group. Ninety minutes after reperfusion, the acupoint catgut embedding group accepted acupoint catgut embedding on Baihui (DU20) acupoint and anterior oblique line of vertex-temporal. After one, three, seven and 14 days of reperfusion, they were assessed with Neurological Evaluation and Screen Prehensile Test. After 14 days of reperfusion, the infarct volume was measured with TTC staining; the expression of glial fibrillary acidic protein (GFAP) and Synapsin I was detected with immunohistochemistry, Western blotting and reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR).
Results Compared with the sham operation group, the neurological score significantly decreased (t > 11.851, P < 0.001), the prehensile time significantly decreased ( t > 6.190, P < 0.001), the expression of GFAP increased ( P < 0.05), and the expression of Synapsin I decreased ( P < 0.05) in the model group. Compared with the model group, the neurological score significantly increased ( t > 3.464, P < 0.001), the prehensile time significantly increased ( t > 3.642, P < 0.001), the cerebral infarction volume significantly decreased ( F = 93.426, P < 0.001), the expression of GFAP decreased ( P < 0.05), and the expression of Synapsin I increased ( P < 0.05) in the acupoint catgut embedding group.
Conclusion Acupoint catgut embedding could promote the recovery of motor function of rats with cerebral ischemia-reperfusion injury, which may be related with inhibiting the proliferation of astrocytes, increasing the regeneration of axons in the ischemic penumbra and enhancing synaptic connection.

Key words: ischemia-reperfusion injury, acupoint catgut embedding, motor function, synaptic plasticity, rats

中图分类号:

R743.3

黄琴,周立志,谭彩玲,郑苏,彭力. 穴位埋线对局灶性脑缺血再灌注损伤大鼠运动功能的影响[J]. 《中国康复理论与实践》, 2020, 26(10): 1167-1175.

HUANG Qin,ZHOU Li-zhi,TAN Cai-ling,ZHENG Su,PENG Li. Effects of Acupoint Catgut Embedding on Motor Function in Cerebral Ischemia-reperfusion Injury in Rats[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(10): 1167-1175.

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组别	n	第1天	第3天	第7天	第14天	F值	P值
假手术组	8	18.000±0.000	18.000±0.000	18.000±0.000	18.000±0.000
模型组	8	9.714±0.680	10.429±0.649	11.143±0.404	12.143±0.349	4.849	0.012
穴位埋线组	8	12.000±0.436	13.000±0.436	14.429±0.481	15.857±0.459	34.972	0.001
F值		84.125	72.633	89.431	80.688
P值		< 0.001	< 0.001	< 0.001	< 0.001
t值^a		12.557	11.851	13.370	12.554
P值^a		< 0.001	< 0.001	< 0.001	< 0.001
t值^b		3.464	4.025	6.406	7.961
P值^b		< 0.001	< 0.001	< 0.001	< 0.001

组别	n	第1天	第3天	第7天	第14天	F值	P值
假手术组	6	56.633±1.570	57.682±1.314	60.000±0.000	60.000±0.000	3.632	0.086
模型组	6	16.248±4.453	20.390±4.613	28.148±3.685	38.028±3.035	28.255	0.002
穴位埋线组	6	41.593±5.143	46.118±4.128	46.920±4.309	53.307±3.113	4.979	0.014
F值		25.636	27.297	23.919	20.132
P值		< 0.001	< 0.001	< 0.001	< 0.001
t值^a		7.084	7.217	6.880	6.190
P值^a		< 0.001	< 0.001	< 0.001	< 0.001
t值^b		4.446	4.979	4.055	4.304
P值^b		< 0.001	< 0.001	< 0.001	< 0.001

组别	n	第1天	第3天	第7天	第14天	F值	P值
假手术组	6	57.905±1.290	58.090±1.744	59.233±0.767	56.518±1.846	0.880	0.474
模型组	6	5.002±0.503	9.040±0.744	12.058±0.557	21.612±1.599	131.541	< 0.001
穴位埋线组	6	11.565±1.719	22.003±1.785	30.260±1.810	37.283±2.027	33.492	< 0.001
F值		511.961	285.814	406.954	91.017
P值		< 0.001	< 0.001	< 0.001	< 0.001
t值^a		29.352	23.070	28.284	13.469
P值^a		< 0.001	< 0.001	< 0.001	< 0.001
t值^b		3.642	6.097	10.913	6.047
P值^b		< 0.001	< 0.001	< 0.001	< 0.001

组别	n	GFAP	突触素I
假手术组	4	0.046±0.008	0.081±0.011
模型组	4	0.061±0.007^a	0.043±0.010^a
穴位埋线组	4	0.035±0.008^b	0.059±0.007^b
F值		4.060	4.230
P值		< 0.05	< 0.05

组别	n	GFAP蛋白	突触素I蛋白
假手术组	4	2.146±0.597	1.348±0.218
模型组	4	3.049±1.223^a	0.515±0.426^a
穴位埋线组	4	1.930±1.177^b	1.156±0.262^b
F值		0.326	1.917
P值		< 0.05	< 0.05

穴位埋线对局灶性脑缺血再灌注损伤大鼠运动功能的影响

Effects of Acupoint Catgut Embedding on Motor Function in Cerebral Ischemia-reperfusion Injury in Rats

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组别	n	脑梗死体积
假手术组	4	0
模型组	4	22.7±1.899
穴位埋线组	4	5.64±0.9384^a

组别	n	GFAP mRNA	突触素I mRNA
假手术组	4	1.439±0.184	2.690±0.096
模型组	4	0.942±0.015^a	0.917±0.065^a
穴位埋线组	4	0.457±0.063^b	1.447±0.069^b
F值		19.014	135.629
P值		< 0.05	< 0.05

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