康复治疗对脑卒中后脑网络运动功能重塑的磁共振研究进展

doi:10.3969/j.issn.1006-9771.2021.05.004

《中国康复理论与实践》 ›› 2021, Vol. 27 ›› Issue (5): 516-521.doi: 10.3969/j.issn.1006-9771.2021.05.004

康复治疗对脑卒中后脑网络运动功能重塑的磁共振研究进展

于少泓^1,²,张豪杰^3,⁴,张通^3,⁴()

^1.山东中医药大学第二附属医院，山东济南市 250001
^2.山东中医药大学第二临床医学院，山东济南市 250001
^3.首都医科大学康复医学院，北京市 100068
^4.中国康复研究中心北京博爱医院，北京市 100068

收稿日期:2020-07-22 修回日期:2020-10-14 出版日期:2021-05-25 发布日期:2021-05-26
通讯作者: 张通 E-mail:tom611@126.com
作者简介:于少泓(1975-)，男，汉族，北京市人，博士，副教授，主要研究方向：中西医脑康复及神经环路功能重塑的研究|张通，男，博士，教授。
基金资助:
中央级公益性科研院所基本科研业务费专项基金项目(2018CZ-2);山东省医药卫生科技发展计划项目(2018WS201);中国康复研究中心项目(2018ZX-10)

Advance in Magnetic Resonance Imaging Research of Rehabilitation Therapy on Cerebral Network Remodeling of Motor Deficits after Stroke (review)

Shao-hong YU^1,²,Hao-jie ZHANG^3,⁴,Tong ZHANG^3,⁴()

^1.The Second Hospital, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250001, China
^2.The Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250001, China
^3.Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
^4.Beijing Bo'ai Hospital, China Rehabilitation Research Centre, Beijing 100068, China

Received:2020-07-22 Revised:2020-10-14 Published:2021-05-25 Online:2021-05-26
Contact: Tong ZHANG E-mail:tom611@126.com
Supported by:
Basic Scientific Research Fund of Central Public Welfare Scientific Research Institutes(2018CZ-2);Shandong Medical Health Technology Development Project(2018WS201);China Rehabilitation Research Center Project(2018ZX-10)

摘要/Abstract

摘要：

随着脑卒中后运动功能障碍研究的不断深入，功能磁共振成像(fMRI)受到广泛关注。脑卒中后皮质下病灶影响附近或远端相关脑区，导致运动功能障碍。镜像神经元疗法、重复性经颅磁、经颅电刺激可通过无创方式激活大脑皮质相关区域，恢复大脑半球之间的平衡，对全脑网络环路有调节作用，但经颅电刺激缺乏A级证据。针灸虽能广泛调节全脑功能网络节点的拓扑结构，但由于针刺选穴、手法、时间、经络的差异，不能全面阐释针灸的治疗机制。康复治疗技术与神经影像学的结合成为脑卒中治疗研究的新方向。

关键词: 脑卒中, 运动, 功能磁共振成像, 脑网络, 综述

Abstract:

With the development of rehabilitation researches for post-stroke motor dysfunction, functional magnetic resonance imaging (fMRI) on nerve injury has also attracted extensive attention. Subcortical lesions of stroke affect nearby or distal brain areas, leading to motor dysfunction. Mirror neuron system therapy, repetitive transcranial magnetic stimulation and transcranial electrical stimulation can activate relevant regions of cerebral cortex in a non-invasive way, and restore the balance between cerebral hemispheres, which can regulate the whole brain network circuit. However, there is a lack of grade A evidence for the effects of transcranial electrical stimulation. Although acupuncture and moxibustion can widely regulate the topological structure of the whole brain functional network nodes, it cannot fully explain the therapeutic mechanism of acupuncture and moxibustion due to the differences of acupuncture point selection, manipulation, time, and channels. The interactive application of rehabilitation therapy and neuroimaging is becoming a new direction of stroke treatment research.

Key words: stroke, motor, functional magnetic resonance imaging, cerebral network, review

中图分类号:

R743.3

于少泓,张豪杰,张通. 康复治疗对脑卒中后脑网络运动功能重塑的磁共振研究进展[J]. 《中国康复理论与实践》, 2021, 27(5): 516-521.

Shao-hong YU,Hao-jie ZHANG,Tong ZHANG. Advance in Magnetic Resonance Imaging Research of Rehabilitation Therapy on Cerebral Network Remodeling of Motor Deficits after Stroke (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(5): 516-521.

参考文献 62

1	GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016 [J]. Lancet. 2017, 390(10100): 1151-1210.
2	BASHYAM V M, ERUS G, DOSHI J, et al. MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide [J]. Brain, 2020, 143(7): 2312-2324.
3	LIM J S, LEE J J, WOO C W, et al. Individual-level lesion-network mapping to visualize the effects of a stroke lesion on the brain network: connectograms in stroke syndromes [J]. J Clin Neurol, 2020, 16(1): 116-123.
4	GRIFFIS J C, METCALF N V, CORBETTA M, et al. Structural disconnections explain brain network dysfunction after stroke [J]. Cell Rep, 2019, 28(10): 2527-2540.
5	林佳丽,田靖,贾杰. 老年脑卒中患者日常生活活动能力与上肢及手运动功能的相关性研究[J]. 老年医学与保健, 2020, 26(3): 362-366.
	LIN J L, TIAN J, JIA J. Study on the correlation between daily living activities and motor function of upper limbs and hands in elderly stroke patients [J]. Geriatr Health Care, 2020, 26 (3): 362-366.
6	孙莉敏,杨浩,孙长慧,等. 运动想象联合常规康复促进脑卒中患者上肢运动功能恢复的fMRI研究[J]. 中华物理医学与康复杂志, 2020, 42(6): 493-499.
	SUN L M, YANG H, SUN C H, et al. The neural mechanism of motor imagery training′s motor recovery effects after stroke [J]. Chin J Phys Med Rehabil, 2020, 42(6): 493-499.
7	姜思竹,谭中建,陈颖,等. 脑卒中偏瘫患者皮层下运动通路脑功能连接变化特点的fMRI研究[J]. 世界中医药, 2017, 12(7): 1495-1499, 1503.
	JIANG S Z, TAN Z J, CHEN Y, et al. Altered functional connectivity in subcortical motor pathways in patients with post-stroke hemiplegia: an fMRI study [J]. World Chin Med, 2017, 12(7): 1495-1499, 1503.
8	刘文洪,罗光华,赵衡,等. 卒中后抑郁患者的脑默认网络功能连接性的rs-fMRI分析[J]. 中国当代医药, 2017, 24(25): 113-115, 129.
	LIU W H, LUO G H, ZHAO H, et al. Analysis of depression after stroke in patients with brain function default network connectivity rs-fMRI [J]. Chin Moder Med, 2017, 24(25): 113-115, 129.
9	DE VRIES C F, STAFF R T, WAITER G D, et al. Motion during acquisition is associated with fMRI brain entropy [J]. IEEE J Biomed Health Inform, 2020, 24(2): 586-593.
10	FARINELLI M, CEVOLANI D, GESTIERI L, et al. Brain and behaviour in post-acute stroke: reduction in seeking and posterior cingulate neuronal variability [J]. J Clin Exp Neuropsychol, 2020, 42(6): 584-601.
11	王想敏,赵智勇,尹大志,等. 脑卒中静息态下脑活动异常的比率低频振幅fMRI研究[J]. 磁共振成像, 2016, 7(6): 401-406.
	WANG X M, ZHAO Z Y, YIN D Z, et al. A fractional amplitude of low frequency fluctuation study of resting-state fMRI in stroke [J]. Chin J Magn Reson Imaging, 2016, 7(6): 401-406.
12	杨浩,余秋蓉,魏彧,等. 脑卒中运动功能障碍的局部一致性fMRI研究[J]. 中国康复医学杂志, 2020, 35(1): 10-16.
	YANG H, YU Q R, WEI Y, et al. Brain regional homogeneity alterations at resting state in the patients with motor deficits after stroke [J]. Chin J Rehabil Med, 2020, 35(1): 10-16.
13	FUELSCHER I, CAEYENBERGHS K, ENTICOTT P, et al. Does fMRI repetition suppression reveal mirror neuron activity in the human brain? Insights from univariate and multivariate analysis [J]. Eur J Neurosci, 2019, 50(5): 2877-2892.
14	GATTI R, ROCCA M A, FUMAGALLI S, et al. The effect of action observation/execution on mirror neuron system recruitment: an fMRI study in healthy individuals [J]. Brain Imaging Behav, 2017, 11(2): 565-576.
15	CHATTERJEE A. Reflections on mirror neurons and rehabilitation [J]. Cogn Behav Neurol, 2018, 31(4): 243-244.
16	MAZUREK K A, SCHIEBER M H. Mirror neurons precede non-mirror neurons during action execution [J]. J Neurophysiol, 2019, 122(6): 2630-2635.
17	YUAN T F, CHEN W, SHAN C, et al. Activity-dependent neurorehabilitation beyond physical trainings: "mental exercise" through mirror neuron activation [J]. CNS Neurol Disord Drug Targets, 2015, 14(10): 1267-1271.
18	李应平,张振军,陈武泽,等. 镜像神经元动作观察疗法对脑卒中病人fMRI功能成像的影响[J]. 中西医结合心脑血管病杂志, 2020, 18(3): 519-522.
	LI Y P, ZHANG Z J, CHEN W Z, et al. Effect of mirror neuron action observation therapy on fMRI functional imaging of stroke survivors [J]. Chin J Integr Med Cardio-Cerebrovasc Dis, 2020, 18(3): 519-522.
19	DETTMERS C, NEDELKO V, SCHOENFELD M A. Impact of left versus right hemisphere subcortical stroke on the neural processing of action observation and imagery [J]. Restor Neurol Neurosci, 2015, 33(5): 701-712.
20	GARRISON K A, AZIZ-ZADEH L, WONG S W, et al. Modulating the motor system by action observation after stroke [J]. Stroke, 2013, 44(8): 2247-2253.
21	BRUNNER I C, SKOUEN J S, ERSLAND L, et al. Plasticity and response to action observation: a longitudinal fMRI study of potential mirror neurons in patients with subacute stroke [J]. Neurorehabil Neural Repair, 2014, 28(9): 874-884.
22	朱美红,时美芳,曾明,等. 基于镜像神经元理论的视觉反馈训练在脑卒中患者上肢功能重建中的应用[J]. 中华现代护理杂志, 2020, 26(6): 749-753.
	ZHU M H, SHI M F, ZENG M, et al. Application of visual feedback training based on mirror neuron theory in upper limb function reconstruction in stroke patients [J]. Chin J Mod Nurs, 2020, 26(6): 749-753.
23	SALEH S, YAROSSI M, MANUWEERA T, et al. Network interactions underlying mirror feedback in stroke: a dynamic causal modeling study [J]. Neuroimage Clin, 2016, 13: 46-54.
24	BHASIN A, PADMA SRIVASTAVA M V, KUMARAN S S, et al. Neural interface of mirror therapy in chronic stroke patients: a functional magnetic resonance imaging study [J]. Neurol India, 2012, 60(6): 570-576.
25	HIOKA A, TADA Y, KITAZATO K, et al. Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons [J]. J Clin Neurosci, 2019, 60: 79-83.
26	REYNAUD E, NAVARRO J, LESOURD M, et al. To watch is to work: a review of neuroimaging data on tool use observation network [J]. Neuropsychol Rev, 2019, 29(4): 484-497.
27	ZMEYKINA E, MITTNER M, PAULUS W, et al. Weak rTMS-induced electric fields produce neural entrainment in humans [J]. Sci Rep, 2020, 10(1): 11994.
28	POURZITAKI C, DARDALAS I, POUTOGLIDOU F, et al. The combination of rTMS and pharmacotherapy on in vitro models: a mini-review [J]. CNS Neurol Disord Drug Targets, 2020, 19(3): 220-226.
29	WANG X, LI L, WEI W, et al. Altered activation in sensorimotor network after applying rTMS over the primary motor cortex at different frequencies [J]. Brain Behav, 2020, 10(7): e01670.
30	ZHANG H, SOLLMANN N, CASTRILLÓN G, et al. Intranetwork and internetwork effects of navigated transcranial magnetic stimulation using low- and high-frequency pulse application to the dorsolateral prefrontal cortex: a combined rTMS-fMRI approach [J]. J Clin Neurophysiol, 2020, 37(2): 131-139.
31	DEMIRTAS-TATLIDEDE A, ALONSO-ALONSO M, SHETTY R P, et al. Long-term effects of contralesional rTMS in severe stroke: safety, cortical excitability, and relationship with transcallosal motor fibers [J]. NeuroRehabilitation, 2015, 36(1): 51-59.
32	UEDA R, YAMADA N, ABO M, et al. MRI evaluation of motor function recovery by rTMS and intensive occupational therapy and changes in the activity of motor cortex [J]. Int J Neurosc, 2020, 130(3): 309-317.
33	胡晓宏. BOLD-fMRI成像技术对rTMS治疗脑梗死后上肢功能障碍的研究[D]. 成都:成都体育学院, 2017.
	HU X H. Effect of BOLD-fMRI imaging on rTMS treatment of upper limb dysfunction after cerebral infarction [D]. Chengdu: Chengdu Sport University, 2017.
34	杜鹃. 基于多模态功能磁共振的重复经颅磁刺激促进脑卒中运动功能恢复的作用机制研究[D]. 上海:第二军医大学, 2017.
	DU J. A multi-modal fMRI study on the mechanism of repetitive transcranial magnetic stimulation promoting motor recovery in stroke patients [D]. Shanghai: the Second Military Medical University, 2017.
35	LEFAUCHEUR J P, ALEMAN A, BAEKEN C, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014-2018) [J]. Clin Neurophysiol, 2020, 131(2): 474-528.
36	HORDACRE B, GOLDSWORTHY M R, WELSBY E, et al. Resting state functional connectivity is associated with motor pathway integrity and upper-limb behavior in chronic stroke [J]. Neurorehabil Neural Repair, 2020, 34(6): 547-557.
37	罗红,余茜. 基于静息态fMRI技术观察高频重复经颅磁刺激对出血性脑卒中认知功能的影响[J]. 中华物理医学与康复杂志, 2019, 41(4): 279-282.
	LUO H, YU Q. Chin J Phys Med Rehabil, 2019, 41(4): 279-282.
38	PINK A E, WILLIAMS C, ALDERMAN N, et al. The use of repetitive transcranial magnetic stimulation (rTMS) following traumatic brain injury (TBI): a scoping review [J]. Neuropsychol Rehabil, 2019, 9(1): 1-27.
39	ZHENG Y, ZHONG D, HUANG Y, et al. Effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) on aphasia in cerebrovascular accident patients: protocol of a systematic review and meta-analysis [J]. Medicine (Baltimore), 2019, 98(52): e18561.
40	ZHANG K Y, RUI G, ZHANG J P, et al. Cathodal tDCS exerts neuroprotective effect in rat brain after acute ischemic stroke [J]. BMC Neurosci, 2020, 21(1): 21-27.
41	屈巧俊,王乐,李燕,等. t-DCS联合常规康复干预对脑卒中后上肢运动功能康复作用的fMRI分析[J]. 中西医结合心脑血管病杂志, 2019, 17(19): 3058-3061.
	QU Q J, WANG L, LI Y, et al. fMRI analysis of rehabilitation effect of t-DCS combined with conventional rehabilitation intervention on upper-limb motor function after stroke [J]. Chin J Integr Med Cardio-Cerebrovasc Dis, 2019, 17(19): 3058-3061.
42	DI LAZZARO V, PELLEGRINO G, DI PINO G, et al. Val66Met BDNF gene polymorphism influences human motor cortex plasticity in acute stroke [J]. Brain Stimul, 2015, 8(1): 92-96.
43	LÜDEMANN-PODUBECKÁ J, BÖSL K, ROTHHARDT S, et al. Transcranial direct current stimulation for motor recovery of upper limb function after stroke [J]. Neurosci Biobehav Rev, 2014, 47: 245-259.
44	ELSNER B, KUGLER J, MEHRHOLZ J. Transcranial direct current stimulation (tDCS) for upper limb rehabilitation after stroke: future directions [J]. J Neuroeng Rehabil, 2018, 15(1): 106.
45	PARMA J O, PROFETA V L D S, ANDRADE A G P, et al. TDCS of the primary motor cortex: learning the absolute dimension of a complex motor task [J]. J Mot Behav, 2020, 13: 1-14.
46	JAMIL A, BATSIKADZE G, KUO H I, et al. Current intensity- and polarity-specific online and aftereffects of transcranial direct current stimulation: an fMRI study [J]. Hum Brain Mapp, 2020, 41(6): 1644-1666.
47	LEFEBVRE S, JANN K, SCHMIESING A, et al. Differences in high-definition transcranial direct current stimulation over the motor hotspot versus the premotor cortex on motor network excitability [J]. Sci Rep, 2019, 9(1): 17605.
48	LEFAUCHEUR J P, ANTAL A, AYACHE S S, et al. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS) [J]. Clin Neurophysiol, 2017, 128(1): 56-92.
49	SUN L, CHEN Y Y, FANG J L, et al. Correlation between blood oxygen level dependent fMRI signal and GABA content in anterior cingulate cortex after acupuncture of Hegu (LI4) [J]. Zhen Ci Yan Jiu, 2019, 44(12): 878-883.
50	MA B, YANG J, YUAN A H, et al. Effect of acupuncture and moxibustion on brain functional connectivity network in patients with refractory facial paralysis [J]. Zhongguo Zhen Jiu, 2019, 39(12): 1321-1326.
51	CHEN S Q, CAI D C, CHEN J X, et al. Altered brain regional homogeneity following contralateral acupuncture at Quchi (LI11) and Zusanli (ST36) in ischemic stroke patients with left hemiplegia: an fMRI study [J]. Chin J Integr Med, 2020, 26(1): 20-25.
52	CHUNG W Y, LIU S Y, GAO J C, et al. Modulatory effect of International Standard Scalp Acupuncture on brain activation in the elderly as revealed by resting-state fMRI [J]. Neural Regen Res, 2019, 14(12): 2126-2131.
53	赵义,王苇,周龙江,等. 针刺健康志愿者合谷和外关的脑功能磁共振成像初步研究[J]. 中华物理医学与康复杂志, 2017, 39(5): 355-360.
	ZHAO Y, WANG W, ZHOU L J, et al. A preliminary fMRI study of acupuncture with healthy volunteers [J]. Chin J Phys Med Rehabil, 2017, 39(5): 355-360.
54	赵义,王苇,周龙江,等. 缺血性卒中偏瘫患者运动功能恢复的机制:针刺诱导血氧水平依赖性功能磁共振成像和弥散张量成像研究[J]. 国际脑血管病杂志, 2017, 25(10): 904-909.
	ZHAO Y, WANG W, ZHOU L J, et al. Mechanism of motor recovery in hemiplegic patients with ischemic stroke: a study of acupuncture-induced blood oxygenation level dependent functional magnetic resonance imaging and diffusion tensor imaging [J]. Int J Cerebrovasc Dis, 2017, 25(10): 904-909.
55	HAN X, BAI L, SUN C, et al. Acupuncture enhances communication between cortices with damaged white matters in poststroke motor impairment [J]. Evid Based Complement Alternat Med, 2019, 20(1): 4245-4753.
56	LU G, ZHANG Y, WANG T, et al. Current state of researches on mechanisms of acupuncture in improvement of hypoxia-ischemic diseases of the central nervous system [J]. Zhen Ci Yan Jiu, 2019, 44(5): 388-391.
57	SUH H W, KIM J, KWON O, et al. Neurocircuitry of acupuncture effect on cognitive improvement in patients with mild cognitive impairment using magnetic resonance imaging: a study protocol for a randomized controlled trial [J]. Trials, 2019, 20(1): 310-324.
58	NIERHAUS T, CHANG Y, LIU B, et al. Somatosensory stimulation with XNKQ acupuncture modulates functional connectivity of motor areas [J]. Front Neurosci, 2019, 13: 147-152.
59	CHANG Q Y, LIN Y W, HSIEH C L. Acupuncture and neuroregeneration in ischemic stroke [J]. Neural Regen Res, 2018, 13(4): 573-583.
60	陈瑾,肖碧银,邱小雅,等. 针刺太冲穴及其不同配穴对健康受试者fMRI脑功能成像的影响[J]. 中医杂志, 2019, 60(23): 2017-2022.
	CHEN J, XIAO B Y, QIU X Y, et al. Effects of acupuncture at Taichong (LR3) and adjunct acupoints on brain functional imaging in healthy subjects under functional magnetic resonance imaging [J]. J Tradit Chin Med, 2019, 60(23): 2017-2022.
61	石文英,李平,娄必丹,等. 观察电针健康受试者不同经穴对Resting-state fMRI脑功能连接的影响[J]. 中华中医药学刊, 2017, 35(12): 3029-3032.
	SHI W Y, LI P, LOU B D, et al. Effect of electroacupuncture on healthy subjects' different acupoints on resting-state fMRI brain functional connectivity [J]. Chin Arch Tradit Chin Med, 2017, 35(12): 3029-3032.
62	陆琳,杨万章,秋云海,等. 基于fMRI脑功能成像分析电针刺激健康人通里穴的临床研究[J]. 康复学报, 2018, 28(3): 16-21, 26.
	LU L, YANG W Z, QIU Y H, et al. fMRI analysis on electroacupuncture on Tongli acupoint in healthy people [J]. J Fujian Univ Trad Chin Med, 2018, 28(3): 16-21, 26.

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康复治疗对脑卒中后脑网络运动功能重塑的磁共振研究进展

Advance in Magnetic Resonance Imaging Research of Rehabilitation Therapy on Cerebral Network Remodeling of Motor Deficits after Stroke (review)

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