《中国康复理论与实践》

《中国康复理论与实践》 ›› 2003, Vol. 9 ›› Issue (03): 151-152.

• 专题研究 • 上一篇    下一篇

氟西汀对早期脑卒中后抑郁及总体康复的影响

莫建伟; 高国栋; 叶瑞繁   

  1. 广东省人民医院,广东省老年医学研究所神经内科 广东广州市 510080
  • 收稿日期:2002-12-27 出版日期:2003-03-25 发布日期:2003-03-25

Effcts of fluoxetine on rehabilitation in poststroke depression

MO Jian-wei,GAO Guo-dong,YE Rui-fan   

  1. Neurological Department of Guangdong Provincial Geriatrics Institute,Guangdong Provincial People’s Hospital,Guangzhou 510080,Guangdong,China
  • Received:2002-12-27 Published:2003-03-25 Online:2003-03-25

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摘要： 目的探讨氟西汀对缓解早期脑卒中后抑郁患者的抑郁症状及促进日常生活活动能力(ADL)改善的疗效。方法 42例首次发病2周内的脑卒中后抑郁患者,随机分为氟西汀治疗组和对照组(不使用抗抑郁药)。两组患者分别于治疗前、治疗后4周及6周,用Hamilton抑郁量表(HAMD)及Barthel指数(BI)量表进行评定。结果治疗前两组的HAMD及BI评分均无显著性差异(P>0.05)。治疗4周及6周后,与对照组比较,治疗组HAMD评分极显著减低(P<0.001),BI指数评分显著提高(P<0.01)。结论氟西汀对缓解早期脑卒中后抑郁患者的症状,促进日常生活活动能力的恢复,均具有较好疗效。

关键词: 脑卒中, 抑郁, 日常生活活动能力, 氟西汀

Abstract: ObjectiveTo study the efficacy of fluoxetine on improving depressive symptoms and activities of daily living(ADL) in early poststroke depressive patients.Methods42 early poststroke depressive patients (within 14 days after first stroke) were randomly divited into fluoxetine treatment group and control group (without antidepressive drugs).Evaluation was conducted before the treatment and at 4 and 6 weeks after treatment,using the Hamilton Depression scale(HAMD)and Barthel Index(BI).ResultsThere was no significant difference in HAMD and BI scores between the two groups before the treatment(P>0.05).At 4 and 6 weeks after the treatment, compared with the control group, the fluoxetine treated group demonstrated significant reduced in HAMD scores (P<0.001) and significant improvement in BI scores (P<0.01).ConclusionsFluoxetine is an effictive drug in improving depressive symptoms and ADL in early postsroke depressive patients.

Key words: Stroke, depression, activity of daily living (ADL), fluoxetine