《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (05): 393-394.

• 临床研究 • 上一篇    下一篇

伴或不伴2型糖尿病大血管病变患者血清高灵敏度C-反应蛋白水平

卢洪文; 张银环; 柳林; 沈守祥; 孟祥凤   

  1. 山东省潍坊市人民医院内分泌科 山东潍坊市 261041
  • 收稿日期:2005-01-06 出版日期:2005-05-25 发布日期:2005-05-25

High sensitive Serum C-reaction protein in macrovascular disease with or without type 2 diabetes

LUHong-wen, ZHANG Yin-huan,LIULin, et al   

  1. Department of Endocrinology,Weifang People's Hospital, Weifang 261041,Shandong, China
  • Received:2005-01-06 Published:2005-05-25 Online:2005-05-25

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摘要： 目的观察2型糖尿病及非糖尿病大血管病变患者血清中高灵敏度C 反应蛋白(hsCRP)浓度的变化。方法选择2型糖尿病患者148例,其中伴大血管病变77例,无大血管病变71 例;非糖尿病大血管病变73例,正常人群组75 例。采用ELISA法测定4组患者的血清hsCRP浓度。结果2 型糖尿病患者(合并或不合并大血管病变)以及非糖尿病大血管病变组血清hsCRP水平均明显高于正常对照组(P<0.01或P<0.001);2型糖尿病组与非糖尿病大血管病变组间hsCRP水平无显著性差异(P>0.05);2型糖尿病合并或不合并大血管病变组之间hsCRP水平也无显著性差异(P>0.05)。结论2型糖尿病患者及非糖尿病大血管病变患者体内可能存在慢性低水平炎症反应,CRP可能是2型糖尿病以及动脉粥样硬化发生发展的一个良好预测因子。

关键词: 2型糖尿病, 大血管病变, C-反应蛋白

Abstract: ObjectiveTo observe the changes of high sensitive serum C-reaction protein (hsCRP) in macrovascular disease with or without type 2 diabetes.MethodsThere were 3 groups population in our study:148 type 2 diabetic patients were divided into 2 subgroups:77 patients with macrovascular disease and 71 without macrovascular disease, 73 non-diabetic patients with macrovascular disease and 75 health controls. The concentration of serum hsCRP of all patients were determined by ELISA.ResultsThere was significant difference in concentration of serum hsCRP between type 2 diabetes with or without macrovascular disease groups, non-diabetes macrovascular disease group and control(P<0.01 or P<0.001). However, there was not significant difference between 2 diabetes groups and non- diabetic macrovascular disease group(P>0.05). There was no significant difference in hsCRP between type 2 diabetes with and without macrovascular disease (P>0.05).ConclusionThere may be a chronic inflammatory reaction in patients with type 2 diabetes or macrovascular disease. hsCRP might be a well forecasting factor of the occurrence and development of type 2 diabetes and atherosclerosis.

Key words: type 2 diabetes, macrovascular disease, C-reaction protein