《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (04): 307-308.

• 基础研究 • 上一篇    下一篇

纤维蛋白胶干粉对兔肝创面的止血效果及应用剂量

王大太; 郭树忠; 张旭东; 倪云志   

  1. 第四军医大学附属西京医院整形外科研究所 陕西西安市 710032
  • 收稿日期:2006-03-21 出版日期:2006-04-25 发布日期:2006-04-25

Hemostatic Effect of Fibrin Sealant Powder on Rabbit Liver Wound Surface and Optimized Dosage

WANG Da-tai, GUO Shu-zhong,ZAHNG Xu-dong, et al   

  1. Research Institute of Plastic Surgery, Xijing Hospital, The Fourth Military Medical University, Xi' an 710032, Shaanxi, China
  • Received:2006-03-21 Published:2006-04-25 Online:2006-04-25

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摘要： 目的观察纤维蛋白胶(FS)干粉对严重创伤创面的止血效果,并寻找最佳有效剂量。方法在新西兰大白兔肝脏表面制作面积为1cm2的圆形创面,应用不同剂量的FS干粉,通过出血时间和出血量检测,找出最适宜的FS干粉剂量,同时与明胶海绵、甲壳素棉、普通纱布等的止血效果进行比较。结果FS 10mg/cm2组的止血时间和出血量与FS 8mg/cm2组相比有显著性差异(P<0.05),与FS 12mg/cm2组无显著性差异。FS 10mg/cm2组止血时间最短,出血量最少,与明胶海绵、甲壳素敷料和普通纱布有显著性差异(P<0.05～0.01)。结论FS干粉的止血效果优于明胶海绵、甲壳素敷料以及普通纱布等,最适剂量为10mg/cm2。

关键词: 纤维蛋白胶, 干粉, 止血, 剂量

Abstract: ObjectiveTo investigate the hemostatic effect of fibrin sealant (FS) powder on severe wound surface and find out the minimum effective dosage.Methods1 cm2 round wound surface was made on the liver of New Zealand white rabbits. Different dosages of FS powder were administrated on the wound surface. Bleeding time and bleeding volume were examined to find out optimized dosage. Hemostatic effect of FS powder was observed and compared with chitin cotton, gelfoam and normal gauze.ResultsBleeding time (0.57±0.21 min)and bleeding volume (0.35±0.29 ml)of FS 10 mg/cm2 group were obviously different from FS 8 mg/cm2 group (P<0.05), not significantly different from FS 12 mg/cm2 group. FS 10 mg/cm2 group got the shortest bleeding time and the lowest bleeding volume, which was obviously different from chitin cotton, gelfoam and gauze groups (P<0.05～0.01).ConclusionThe hemostatic effect of FS powder is better than gelfoam, chitin cotton and gauze and its optimized dosage is 10 mg/cm2.

Key words: fibrin sealant, powder, hemostasis, dosage