《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (01): 26-28.

• 专题　药物康复 • 上一篇    下一篇

中药诱导脑成体神经干细胞的增殖分化

王文1; 黄文婷2; 艾厚喜1; 安宜2; 李林1   

  1. 1.首都医科大学宣武医院药物研究室,教育部神经变性病学重点实验室,北京市 100053;2.北京理工大学生命科学与技术学院生物技术系,北京市 100081
  • 收稿日期:2006-10-18 出版日期:2007-01-01 发布日期:2007-01-01

Proliferation and Differentiation of Adult Neural Stem Cell Induced by Traditional Chinese Medicine in Brain

WANG Wen, HUANG Wen-ting, AI Hou-xi, et al   

  1. Department of Pharmacology, Xuanwu Hospital of Capital Medical Universitye, Key Laboratory for Neurodegenerative Disease of Education Ministry of China, Beijing 100053, China
  • Received:2006-10-18 Published:2007-01-01 Online:2007-01-01

PDF (PC)

被引次数

70

摘要： 神经干细胞是具有自我更新和多向分化潜能的一类细胞,其增殖分化与生长因子、细胞因子、环境信号等因素密切相关。近年来,成年脑组织内也发现了具有多向分化潜能的神经干细胞,成体神经干细胞的发现改变了以往中枢系统不可再生的理论。中药能够有效地诱导成体神经干细胞的增殖分化,为神经再生治疗策略开辟了崭新的研究方向,并在治疗缺血性脑损伤中显示出巨大潜能。

关键词: 神经干细胞, 成年, 增殖, 分化, 中药, 缺血性脑损伤, 综述

Abstract: Neural stem cells are a category of cells with self-renewal and differentiation potential. Proliferation and differentiation of neural stem cells have closely relation with growth factor, cell factor, environmental signal, and so on. In recent years, evidence indicates that neural stem cells possessing multipotency naturally occur in adult brain. The found of adult neural stem cells have changed the theory that central nervous system cannot regenerative. Chinese Traditional Medicine can effectively induce adult neural stem cells to proliferate and differentiate, opening up unprecedented direction in the research for the treatment of nerve regeneration, and showing great potency for curing cerebral ischemic injury.

Key words: neural stem cells, adult, proliferation, differentiation, Chinese Traditional Medicine, cerebral ischemic injury, review