《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (04): 358-360.

• 临床研究 • 上一篇    下一篇

A型肉毒毒素缓解脑瘫痉挛的适宜剂量与相关因素的研究

刘建军; 纪树荣; 胡莹媛; 吴卫红; 李燕春; 陆华宝; 张雁   

  1. 1.首都医科大学康复医学院,北京市 100068;2.中国康复研究中心北京博爱医院,北京市 10068
  • 收稿日期:2007-07-19 出版日期:2008-04-01 发布日期:2008-04-01

Suitable Dose and Correlation Factors in Treatment of Spastic Cerebral Palsy by Botulinum Toxic A Block

LIU Jian-jun, JI Shu-rong, HU Ying-yuan, et al.   

  1. CapitalMedical University School of Rehabilitation Medicine, BeijingCharity Hospital, ChinaRehabilitation Research Center, Beijing 100068, China
  • Received:2007-07-19 Published:2008-04-01 Online:2008-04-01

PDF (PC)

被引次数

45

摘要： 目的探讨A型肉毒毒素(BTX-A)缓解脑瘫痉挛的适宜剂量与程度及与其他因素的关系。方法对39例脑瘫患儿采用BTX-A局部注射缓解痉挛。结果23例患儿治疗后效果良好,其中男性15例、女性8例,年龄33～145个月,平均(60.7±26.9)个月。BTX-A的适宜剂量与患儿的性别、年龄、体重、诊断分型、粗大运动功能分级(GMFCS)、致病因素、注射点数目无相关性,与术前改良Ashworth量表(MAS)评分呈线性正相关。结论BTX-A可缓解脑瘫患儿的痉挛,注射剂量与MAS评分呈正相关。

关键词: 脑性瘫痪, 痉挛, A型肉毒毒素, 神经阻滞, 剂量

Abstract: Objective To investigate the optimal dose of botulinum toxic A(BTX-A)for releasing spasticity of cerebral palsy(CP)and related factors.Methods 39 children with CP was treated by BTX-A injected in local muscles to release the spasticity.Results After treatment,23 children had good curative effect.In them,15 cases were male,8 cases were female,the mean age was 60.7±26.9 months(range 33 to 145 months).There was no correlation between the optimal unit dose of BTX-A and those including sex,age,body weight,diagnosis type,degree of Gross Motor Function Classification System(GMFCS),etiological factor and the injections.There was a linear positive correlation between the optimal unit dose of BTX-A and the score of Modified Ashworth Scale(MAS).Conclusion BTX-A can release the spasticity of CP children,the injecting dose is correlated with MAS score.

Key words: cerebral palsy, spasticity, botulinum toxic A, nerve block, dose