《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (11): 1043-1045.

• 论文 • 上一篇    下一篇

肌电生物反馈联合早期康复对脑梗死患者疗效及对血清基质金属蛋白酶-9 的影响

张建斌，费丽萍，李晓慧，张丽玲
   

  1. 山西省长治医学院附属和济医院，山西长治市046000。
  • 收稿日期:2013-05-22 修回日期:2013-08-16 出版日期:2013-11-25 发布日期:2013-11-25

Effects of Electromyographic Biofeedback and Earlier Rehabilitation on Neural Function and Serum Matrix Metalloproteinase-9 of Patients with Cerebral Infarction

ZHANG Jian-bin, FEI Li-ping, LI Xiao-hui, et al.
  

  1. Department of Neurology, Heji Hospital Affiliated to the Medical College of Changzhi, Changzhi 046000, Shanxi, China
  • Received:2013-05-22 Revised:2013-08-16 Published:2013-11-25 Online:2013-11-25

摘要： 目的研究肌电生物反馈联合早期康复对急性脑梗死患者临床疗效和血清基质金属蛋白酶-9(MMP-9)水平的影响。方法90 例急性脑梗死偏瘫患者，采用随机数字表法分为对照组(n=30)、康复组(n=30)和综合组(n=30)。所有患者均接受常规药物治疗，康复组采用早期康复，综合组采用肌电生物反馈联合早期康复，治疗2 周。于治疗前后采用临床神经功能缺损评分(CNFDS)及改良Barthel 指数(MBI)进行评定，检测血清MMP-9 水平。结果治疗后，各组CNFDS 评分显著下降，MBI 评分显著升高(P<0.001)，综合组明显优于康复组、对照组(P<0.01)。各组血清MMP-9 水平下降，综合组下降更明显(P<0.001)。结论肌电生物反馈联合早期康复可促进神经功能的恢复，机制可能与降低血清MMP-9 水平有关。

关键词: 脑梗死, 肌电生物反馈, 早期康复, 基质金属蛋白酶-9

Abstract: Objective To observe the effect of electromyographic biofeedback combined with earlier rehabilitation on serum matrix metalloproteinase-9 (MMP-9) and its clinical efficacy for patients with cerebral infarction. Methods 90 patients with acute cerebral infarction were randomly divided into control group (n=30), rehabilitation group (n=30) and combination group (n=30). All the groups received basic medication, and the rehabilitation group combined with earlier rehabilitation, the combination group with electromyographic biofeedback and earlier rehabilitation. All patients were evaluated with Clinical Neurologic Functional Default Scoring (CNFDS) and the modified Barthel Index (MBI) before and 2 weeks after treatment. Their serum levels of MMP-9 were detected as well. Results The scores of CNFDS and MBI improved after treatment in all the groups (P<0.001), especially in the combination group (P<0.01). The levels of MMP-9 decreased more in combination group than in the rehabilitation group and the control group (P<0.001). Conclusion Electromyographic biofeedback combined with earlier rehabilitation can facilitate the recovery neural function, which may associated with the decrease of MMP-9.

Key words: cerebral infarction, electromyogmphic biofeedback, earlier rehabilitation, matrix metalloproteinase-9