癌因性疲劳与下丘脑-垂体-肾上腺轴关系研究进展

doi:10.3969/j.issn.1006-9771.2017.04.009

摘要/Abstract

摘要： 癌因性疲劳患者清晨血清皮质醇浓度较非疲劳患者低，其昼夜节律变化幅度较小，面对压力时皮质醇反应较迟钝。其机制可能与下丘脑-垂体-肾上腺轴失调导致炎症反应相关，也有证据支持皮质类固醇激素短期内使用能够改善癌因性疲劳。本文就近年来癌因性疲劳与下丘脑-垂体-肾上腺轴关系的研究进展进行综述。

关键词: 癌因性疲劳, 下丘脑-垂体-肾上腺轴, 皮质醇, 综述

Abstract: Cancer-related fatigue survivors have been found to have lower morning serum cortisol levels, flattened diurnal cortisol cycles, and decreased cortisol responses to psychological stress. The mechanism may be related to the inflammation caused by disorder of hypothalamus-pituitary-adrenal axis, and there are also some evidences to support that cortisol can be used to reduce cancer-related fatigue. This study introduced the research progress of the relationship between cancer-related fatigue and hypothalamus-pituitary-adrenal axis.

Key words: cancer-related fatigue, hypothalamic-pituitary-adrenal axis, cortisol, review

中图分类号:

R730.5

苏羚子，李柏. 癌因性疲劳与下丘脑-垂体-肾上腺轴关系研究进展[J]. 《中国康复理论与实践》, 2017, 23(4): 406-409.

SU Ling-zi, LI Bai. Relationship between Cancer-related Fatigue and Hypothalamic-pituitary-adrenal Axis (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(4): 406-409.

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