microRNA调节肌肉萎缩作用机制的研究进展

doi:10.3969/j.issn.1006-9771.2019.04.012

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (4): 434-438.doi: 10.3969/j.issn.1006-9771.2019.04.012

microRNA调节肌肉萎缩作用机制的研究进展

马翔, 唐成林, 吴梦佳, 安荟羽, 万小凤, 谯童茜

重庆医科大学中医药学院，重庆市 400016

收稿日期:2018-10-11 修回日期:2018-12-03 出版日期:2019-04-20 发布日期:2019-04-24
通讯作者: 唐成林，E-mail: cytcl996@163.com
作者简介:马翔(1994-)，男，汉族，新疆霍城县人，硕士研究生，主要研究方向：针灸推拿机制研究。
基金资助:
1.国家自然科学基金项目(No. 81273870)；2.重庆市卫生和计划生育委员会、重庆市科学技术委员会联合项目(No. ZY201801007)

Advance in Mechanism of microRNA Regulating Muscle Atrophy (review)

MA Xiang, TANG Cheng-lin, WU Meng-jia, AN Hui-yu, WAN Xiao-feng, QIAO Tong-qian

College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China

Received:2018-10-11 Revised:2018-12-03 Published:2019-04-20 Online:2019-04-24
Contact: TANG Cheng-lin, E-mail: cytcl996@163.com
Supported by:
National Natural Science Foundation of China (No. 81273870) and Joint Programme of Chongqing Health and Family Planning Committee and Chongqing Science and Technology Committee (No. ZY201801007).

摘要/Abstract

摘要： 骨骼肌萎缩后肌肉正常功能受损，这将极大降低个人生活质量。目前并没有成熟有效的方法治疗肌肉萎缩。microRNA作为一类小分子非编码RNA，为治疗肌肉萎缩带来新的希望。microRNA调节肌肉萎缩的作用机制主要包括：通过泛素-蛋白酶体途径(UPS)和哺乳动物雷帕霉素靶蛋白通路(IGF/PI3K/Akt/mTOR)调节异常肌肉蛋白质代谢，通过抑制细胞凋亡因子表达抑制肌细胞异常凋亡，通过调控成肌因子表达促进肌肉再生，通过促进血管生长因子表达促进血管再生等。

关键词: 微RNA, 肌肉萎缩, 综述

Abstract: Muscle loses normal function after skeletal muscle atrophy that will greatly reduce the quality of personal life. There is no effective way to treat muscle atrophy currently. microRNA (miRNA) as a small molecule of non-coding RNA brings new hope for the treatment of muscular atrophy. The mechanism of miRNA regulating muscle atrophy mainly includes: regulating abnormal muscle protein metabolism by ubiquitin-proteasome system (UPS) and mammalian target of rapamycin pathway (IGF/PI3K/Akt/mTOR), inhibiting abnormal apoptosis of muscle cells by inhibiting the expression of apoptotic factors, promoting muscle regeneration by regulating myogenic factor expression, and promoting angiogenesis by promoting the expression of angiogenic factors, and so on.

Key words: microRNA, muscle atrophy, review

中图分类号:

R685.4

马翔, 唐成林, 吴梦佳, 安荟羽, 万小凤, 谯童茜. microRNA调节肌肉萎缩作用机制的研究进展[J]. 《中国康复理论与实践》, 2019, 25(4): 434-438.

MA Xiang, TANG Cheng-lin, WU Meng-jia, AN Hui-yu, WAN Xiao-feng, QIAO Tong-qian. Advance in Mechanism of microRNA Regulating Muscle Atrophy (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(4): 434-438.

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microRNA调节肌肉萎缩作用机制的研究进展

Advance in Mechanism of microRNA Regulating Muscle Atrophy (review)

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