脊髓损伤后微环境中免疫反应的文献计量分析

doi:10.3969/j.issn.1006-9771.2024.11.010

《中国康复理论与实践》 ›› 2024, Vol. 30 ›› Issue (11): 1322-1333.doi: 10.3969/j.issn.1006-9771.2024.11.010

脊髓损伤后微环境中免疫反应的文献计量分析

杜华勇¹^,², 李泽辉¹^,², 王晓昕¹^,², 荆瀛黎³, 高峰¹^,², 杨德刚¹^,², 李建军¹^,²^,³()

1.首都医科大学康复医学院，北京市 100068
2.中国康复研究中心脊柱与神经功能重建科，北京市 100068
3.中国康复科学所，北京市 100068

收稿日期:2024-06-26 修回日期:2024-10-12 出版日期:2024-11-25 发布日期:2024-12-05
通讯作者: 李建军(1962-)，男，汉族，山东人，教授、主任医师，博士研究生/博士后导师，主要研究方向：骨科、脊柱脊髓外科和脊髓损伤的治疗与康复。E-mail：13718331416@163.com
作者简介:杜华勇(1999-)，男，汉族，贵州铜仁市人，硕士研究生，主要研究方向：脊髓损伤相关的康复。
基金资助:
国家社会科学基金重大项目(2021ZD-187);中国康复研究中心重点课题(2021ZX-07)

Immune responses in the microenvironment after spinal cord injury: a bibliometric analysis

DU Huayong¹^,², LI Zehui¹^,², WANG Xiaoxin¹^,², JING Yingli³, GAO Feng¹^,², YANG Degang¹^,², LI Jianjun¹^,²^,³()

1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
2. Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing 100068, China
3. China Rehabilitation Science Institute, Beijing 100068, China

Received:2024-06-26 Revised:2024-10-12 Published:2024-11-25 Online:2024-12-05
Contact: LI Jianjun, E-mail: 13718331416@163.com
Supported by:
National Social Science Fund of China (Major)(2021ZD-187);China Rehabilitation Research Center Project(2021ZX-07)

摘要/Abstract

摘要：

目的分析脊髓损伤后微环境中免疫反应领域的研究现状、热点和发展趋势。

方法在中国知网和Web of Science核心合集，检索自建库起至2024年3月期间脊髓损伤后微环境中免疫反应相关研究的文献，采用VOSviewer和CiteSpace对纳入文献的作者、国家、机构、期刊、共被引文献和关键词进行可视化分析并绘制知识图谱。

结果共纳入152篇中文文献和455篇英文文献。中、英文发文量逐年增加，中国和美国是该领域的主要研究国家。中文文献中，朱悦是高产作者，中国医科大学是高产机构。英文文献中，Phillip Popovich是高产且高被引作者，俄亥俄州立大学是高产机构。Journal of Neuroscience和Experimental Neurology是重要期刊。中英文研究热点集中在免疫激活、炎症反应和功能恢复等，干细胞移植、巨噬细胞和中医药等在脊髓损伤后免疫反应调控中的研究占比较大。

结论微环境中的免疫反应已经成为脊髓损伤领域关注的焦点，研究重点正从免疫机制转向免疫调控策略的探索，一些前沿技术在这方面展现出巨大潜力。未来需加强跨地域、跨机构合作，促进信息共享，加速研究进展和临床转化，以提升患者康复效果。

关键词: 脊髓损伤, 微环境, 免疫反应, 文献计量学

Abstract:

Objective To analyze the current status, research hotspots and development trends in the field of immune responses in the microenvironment after spinal cord injury (SCI).

Methods Literatrues about immune responses in the microenvironment after SCI were searched from CNKI and the Web of Science Core Collection, from inception to March, 2024. VOSviewer and CiteSpace were used to conduct a visual analysis of authors, countries, institutions, journals, co-cited references and keywords.

Results A total of 152 Chinese and 455 English studies were included. The number of publications increased annually, and China and the United States were leading research efforts in this field. In the Chinese literature, Zhu Yue was the most prolific author, and China Medical University was the leading institution. In the English literature, Phillip Popovich was the most prolific and highly cited author, and Ohio State University was the leading institution. Journal of Neuroscience and Experimental Neurology were identified as key journals. The research hotspots in both languages focused on immune activation, inflammatory response and functional recovery. Researches on stem cell transplantation, macrophage and traditional Chinese medicine were particularly prominent in the regulation of immune responses after SCI.

Conclusion Immune responses in the microenvironment have emerged as a central focus in SCI research. The emphasis of current researches is shifting from mechanistic exploration to the investigation of immunomodulatory strategies, with several cutting-edge technologies showing significant potential in this regard. Moving forward, increasing collaboration across regions and institutions are essential to promote information sharing, accelerate scientific progress, and facilitate clinical translation, ultimately enhance patient rehabilitation outcomes.

Key words: spinal cord injury, microenvironment, immune response, bibliometrics

中图分类号:

R651.2

杜华勇, 李泽辉, 王晓昕, 荆瀛黎, 高峰, 杨德刚, 李建军. 脊髓损伤后微环境中免疫反应的文献计量分析[J]. 《中国康复理论与实践》, 2024, 30(11): 1322-1333.

DU Huayong, LI Zehui, WANG Xiaoxin, JING Yingli, GAO Feng, YANG Degang, LI Jianjun. Immune responses in the microenvironment after spinal cord injury: a bibliometric analysis[J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(11): 1322-1333.

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序号	机构	发文量/n	序号	机构	发文量/n	中心性
1	中国医科大学	14	1	俄亥俄州立大学	33	0.28
2	第四军医大学	12	2	加利福尼亚大学	15	0.11
3	西安交通大学	8	3	罗格斯大学	10	0.08
4	广西医科大学	6	4	柏林夏里特医学院	9	0.02
5	郑州大学	6	5	柏林自由大学	9	0.02
6	成都医学院	5	6	柏林健康研究所	9	0.02

排名	作者	发文量	引用量	平均被引量
1	Phillip Popovich	17	2046	120.35
2	Michael Fehlings	9	284	31.56
3	Jan Schwab	8	355	44.38
4	John R Bethea	7	165	23.57
5	Ona Bloom	7	138	19.71
6	Aileen J Anderson	6	678	113.00

排名	期刊	载文量	引用量	平均引用量
1	Journal of Neuroinflammation	28	1252	44.71
2	Journal of Neurotrauma	23	589	25.61
3	Experimental Neurology	19	1689	88.89
4	Journal of Neuroscience	15	1484	98.93
5	Neural Regeneration Research	11	325	29.55

标签	节点数	轮廓值	年份	规模
#0	24	0.898	2005	spinal cord injury; immune activation; axon
#1	15	0.869	2015	leukocytes; adaptive immunity; immune response; neurogenesis; spinal cord injury
#2	15	0.901	2009	innate immune response; adaptive immune response; stem cells; spinal cord injury
#3	14	0.913	2012	dendritic cells; bone marrow; antigen presenting cells;
#4	14	0.935	2006	monocytes; minocycline; spinal cord injury; functional recovery
#5	13	0.833	2016	neuropathic pain; immune cells; major histocompatibility complex class; bioactive lipids
#6	11	0.946	2005	hypothalamic-pituitary-adrenal axis; cyclooxygenase-2; TANK-binding kinase 1; NF-κB
#7	10	0.932	2016	angiogenesis; autophagy; CXC chemokine receptor 4; lymphangiogenesis

脊髓损伤后微环境中免疫反应的文献计量分析

Immune responses in the microenvironment after spinal cord injury: a bibliometric analysis

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