《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2019, Vol. 25 ›› Issue (3): 255-260.doi: 10.3969/j.issn.1006-9771.2019.03.002

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Effects of Transcranial Direct Current Stimulation on Cognitive Function after Aging and Alzheimer's Disease (review)

LEI Xing-xing1, GU Bin1,2, SONG Lu-ping1,2,3   

  1. 1.Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
    2.Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
    3.Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China
  • Received:2018-05-20 Revised:2018-06-22 Published:2019-03-25 Online:2019-04-02
  • Contact: SONG Lu-ping, E-mail: songluping882002@aliyun.com
  • Supported by:
    National Key Research and Development Program (No. 2016YFF0201002) and National Special Fund Projects of Basic Research of Public Benefits for Institutes at Central Governmental Level (No. 2016CZ-6)

Abstract: Aging leads to cognitive decline, including memory, attention, language and execution. Alzheimer's disease (AD) is a progressive neurodegenerative disorder closely related to age. Decreased cognitive function is one of its core symptoms. Transcranial direct current stimulation (tDCS) has been used in old healthy adults and AD patients to improve aging-related cognitive impairment. tDCS can improve memory (situational memory, semantic memory and working memory), language, error awareness and attentional functions in the old adults, which were influenced by many factors, such as education levels, stimulation parameters and individual task baseline scores, etc. For AD patients, tDCS may improve their cognitive function, which is influenced by the factors as anatomical differences, severity of disease, stimulation parameters and assessment tools, etc. Cognitive training combined with tDCS can further improve cognitive function in old adults and AD patients.

Key words: aging, Alzheimer's disease, transcranial direct current stimulation, cognitive function, review

CLC Number: