›› 2019, Vol. 25 ›› Issue (5): 534-539.doi: 10.3969/j.issn.1006-9771.2019.00.002

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Advance in Pericytes and Related Angiogenic Signaling Pathways after Cerebral Ischemia (review)

ZHANG Di1, XU Ming-shu2, ZHANG Ying-jie2, CHENG Ai-fang1, GUAN Hua-zong1   

  1. 1.Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China
    2.Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China
  • Received:2018-08-30 Revised:2018-10-19 Online:2019-05-25 Published:2019-05-29
  • Contact: XU Ming-shu, E-mail: mingshuxu@163.com
  • Supported by:
    Shanghai Committee of Science and Technology Research Plan (No. 17ZR1427500) and Shanghai Municipal Commission of Health and Family Planning Research Plan (No. 201640128)

Abstract: Pericytes, endothelial cells (EC), astrocytes and extracellular space together constitute the blood-brain barrier. Pericytes and EC participate in the various regulations of blood-brain barriers through many mechanisms to maintain the stability of neurovascular units (NVU). The injury and repair of NVU involve a lot of signal transduction at molecular levels, and angiogenesis is primarily about the generation and maturation of EC and the supporting adhesion process of pericytes. This article briefly reviewed EC-related angiogenesis signaling pathways in pericytes after NVU ischemic injury.

Key words: cerebral ischemia, pericytes, endothelial cell, angiogenesis, neurovascular unit

CLC Number: