神经颗粒素对中枢神经系统疾病认知功能障碍作用的研究进展

doi:10.3969/j.issn.1006-9771.2020.03.012

Abstract

Abstract:

Neurogranin (Ng), as a neuron-specific postsynaptic protein, is abundant in the cerebral cortex and hippocampus. Ng may alter the affinity with calmodulin through phosphorylation and redox, and participate in the calcium signal pathway through glutamate receptor, to regulate the information transfer and synaptic plasticity. Ng involves in the formation and encoding of memories in related brain regions and plays an important role in learning, memory and cognitive function. Ng is associated with cognitive decline in Alzheimer's disease and can be used as a synaptic biomarker for diagnosis. Cognitive dysfunction after stroke is associated with decrease of Ng expression in the brain. Ng is one of the sites of genetic variants associated with susceptibility to schizophrenia.

Key words: neurogranin, synaptic plasticity, cognitive impairment, review

CLC Number:

R741

ZHANG Jia-yong,LIU Wei-lin,CHEN Li-dian,TAO Jing. Advance in Neurogranin for Cognitive Impairment Second to Central Nervous System Diseases (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(3): 325-329.

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Advance in Neurogranin for Cognitive Impairment Second to Central Nervous System Diseases (review)

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