间充质干细胞治疗脊髓损伤的可视化分析

doi:10.3969/j.issn.1006-9771.2020.04.006

Abstract

Abstract:

Objective To analyze the research status and hotspots of mesenchymal stem cells (MSCs) for treatment of spinal cord injury in the past five years.Methods The related literatures from 2014 to 2018 in Science Citation Index-Expanded (SCI-E) of Web of Science (WOS) were included. CiteSpace software was used to analyze the cooperation relationship of authors, countries and research institutions. The keywords were taken as nodes for co-occurrence analysis, cluster analysis, dynamic frontier evolution and burst analysis. The co-citation of journals and literatures were taken as nodes for analysis, meanwhile, the visual maps were drawn and the results were analyzed.Results and Conclusion A total of 236 authors were included, out of whom 49 authors published more than three papers, and high-yielding authors were mainly represented by Zeng Y S and Chen L. There were 162 countries/institutions involved, out of which 85 published more than three papers. Seventy-five journals were included, out of which Exp Neurol was the one with the most articles. There were 107 key words included, and the hot words were spinal cord injury, MSCs, transplantation, bone marrow, repair, and functional recovery, which formed six cluster groups. The trend was to extract and culture progenitor cells and induce their directional differentiation; mechanism of immune regulation, anti-inflammatory and nerve regeneration in the treatment of spinal cord injury by MSCs, as well as the research of tissue engineering technology, biological materials in this field.

Key words: spinal cord injury, mesenchymal stem cells, CiteSpace, Web of Science, visual analysis

CLC Number:

R651.2

YE Jia-mei,HU Xiao-min,WANG Li-qun,WANG Wen-chun,ZHANG An-ren. Researches on Mesenchymal Stem Cells for Treatment of Spinal Cord Injury: A Visualization Analysis[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(4): 400-406.

Figures/Tables 12

References 37

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聚类ID	包含关键词
2	条件培养基、组织工程、创伤性脑损伤、支架、神经再生、干细胞/祖细胞、功能恢复、神经元、神经变性疾病等
3	损伤、骨髓基质细胞、施万细胞、轴突再生、呼吸黏膜间充质干细胞、脊髓损伤、神经蛋白聚糖、神经元分化、感觉轴突、突触可塑性等
4	神经修复、转化神经科学、细胞再生疗法、骨骼肌再生、运动恢复、细胞疗法、临床神经修复、完全性慢性脊髓损伤等
5	创伤性脑损伤、神经保护、脊髓损伤、神经干细胞、视网膜神经节细胞、介导免疫抑制、分化能力、分泌因子、趋化因子受体等

Researches on Mesenchymal Stem Cells for Treatment of Spinal Cord Injury: A Visualization Analysis

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排名	频次	文献题名	作者	发表年份
1	48	Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury	Nakajima H	2012
2	45	Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications	Wright KT	2011
3	40	Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome	Osaka M	2010
4	38	Mesenchymal stem cell graft improves recovery after spinal cord injury in adult rats through neurotrophic and pro-angiogenic actions	Quertainmont R	2012
5	31	BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury	Sasaki M	2009

排名	中心度	文献题名	作者	发表年份
1	0.21	A systematic review of cellular transplantation therapies for spinal cord injury	Tetzlaff W	2011
2	0.20	Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury	Nakajima H	2012
3	0.13	Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome	Osaka M	2010
4	0.11	Long-term results of spinal cord injury therapy using mesenchymal stem cells derived from bone marrow in humans	Park JH	2012
5	0.11	Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury	Ryu H H	2009

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