轻度阿尔茨海默病患者治疗前后海马亚区体积的磁共振成像研究

doi:10.3969/j.issn.1006-9771.2020.05.020

Abstract

Abstract:

Objective To investigate the hippocampal subfield volumes before and after taking hydrochloric donepezil in patients with mild Alzheimer's disease (AD).Methods From January, 2017 to June, 2018, 25 mild AD patients accepted hydrochloric donepezil (treatment group), 25 patients accepted placebo (placebo group) and 25 age- and gender-matched healthy old people (control group) were scanned with magnetic resonance imaging (MRI) under 3D-T₁ TFE sequence before and after a six-month treatment, and the automated segmentation of the hippocampus subfields was fulfilled with FreeSurfer and the hippocampus subfield volumes were compared, while the patients were assessed with Mini-Mental State Examination (MMSE).Results Compared with the control group, the volumes of left CA1, CA2-3 and CA4-DG, and right CA1 and CA2-3 were reduced in patients before treatment (t > 2.294, P< 0.05). The volume of left CA4-DG increased in the treatment group compared with that of the placebo group after treatment (t = 2.196, P< 0.05), and the volume of bilateral CA1 and CA2-3 tended to increase but not significantly (t < 1.888, P> 0.065). The MMSE score was more in the treatment group than in the placebo group after treatment (t = 2.764, P< 0.05).Conclusion The association with asymmetric atrophy in the hippocampal subfields has been found in mild AD patients, especially in left CA4-DG, which may be used as a valuable marker for diagnosis and evaluation for treatment at early stage.

Key words: Alzheimer's disease, hippocampus, magnetic resonance imaging, diagnosis, evaluation

CLC Number:

R749.1

LIU Yu,CAO Zhi-hong,LUO Yi-feng,SHAN Hai-rong,XIE Wen-chao,ZHANG Xiao-jie,WANG Wen-yun. Hippocampal Subfield Volumes before and after Treatment for Mild Alzheimer's Disease: Study with Magnetic Resonance Imaging[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(5): 592-596.

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组别	n	性别 (男/女, n)	年龄(岁)	教育程度(年)
对照组	25	13/12	62.3±10.4	5.6±1.3
轻度AD组	25	14/11	63.8±10.6	6.3±2.0
χ²/t值		0.081	0.505	1.467
P值		0.777	0.616	0.149

组别	n	左CA1	左CA2-3	左CA4-DG	左下托	左旁下托	左海马伞
对照组	25	296.38±36.46	980.32±94.72	554.21±53.44	620.32±52.78	443.31±51.13	67.32±15.98
轻度AD组	25	269.36±35.88	915.45±93.18	517.37±55.03	612.75±50.22	429.17±53.08	61.62±15.90
t值		2.641	2.441	2.401	0.520	0.959	1.264
P值		0.011	0.018	0.020	0.606	0.342	0.212
组别	n	右CA1	右CA2-3	右CA4-DG	右下托	右旁下托	右海马伞
对照组	25	304.50±36.92	983.59±102.39	565.04±57.79	625.99±54.32	466.83±49.79	65.16±16.58
轻度AD组	25	280.16±38.11	916.21±99.82	550.32±56.90	630.21±55.12	455.76±47.10	63.77±15.68
t值		2.294	2.356	0.908	0.273	0.808	0.305
P值		0.026	0.023	0.369	0.786	0.423	0.762

组别	n	左CA1	左CA2-3	左CA4-DG	左下托	左旁下托	左海马伞
安慰剂组	25	271.14±34.97	916.32±94.21	516.42±55.12	616.45±51.06	427.19±55.12	61.45±16.07
治疗组	25	290.10±33.91	966.74±93.26	550.38±54.21	615.48±53.18	432.18±52.07	64.31±16.71
t值		1.946	1.902	2.196	0.066	0.329	0.617
P值		0.058	0.063	0.033	0.948	0.744	0.540
组别	n	右CA1	右CA2-3	右CA4-DG	右下托	右旁下托	右海马伞
安慰剂组	25	281.13±37.48	922.23±98.07	549.42±55.82	632.37± 55.33	457.88±48.90	63.99±16.34
治疗组	25	302.13±36.89	973.73±94.81	555.32±54.81	631.22±55.47	461.30±49.11	64.82±16.73
t值		1.997	1.888	0.377	0.073	0.247	0.178
P值		0.052	0.065	0.708	0.942	0.806	0.860

组别	n	治疗前	治疗后
安慰剂组	25	20.87±3.92	21.51±4.12
治疗组	25	21.38±4.03	24.83±4.37
t值		0.454	2.764
P值		0.652	0.008

Hippocampal Subfield Volumes before and after Treatment for Mild Alzheimer's Disease: Study with Magnetic Resonance Imaging

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