高频重复经颅磁刺激对大鼠工作记忆局部场电位和锋电位时频特征的影响

doi:10.3969/j.issn.1006-9771.2020.12.005

Abstract

Abstract:

Objective To investigate the effects of high frequency repetitive transcranial magnetic stimulation (rTMS) on learning memory and neuroelectric activity in rats.Methods Eight Wistar rats were randomly divided into control group (n = 4) and rTMS group (n = 4). rTMS group was stimulated 14 days by rTMS with the frequency of 5 Hz, and the stimulation intensity was 100% motor threshold. The control group did not accepted rTMS. Then, the 16 channel local field potentials (LFPs) and spikes were recorded from their prefrontal cortex (PFC) in each group during the working memory tasks. The time-frequency analysis based on the short-time Fourier transform was performed on the LFPs, and the spike was analyzed by the release rate method. Multitaper Spectral Coherence was used to analyze the Synchronization Degree of LFPs-spike.Results In the working memory experiment, rTMS group needed less days than the control group to reach the task correction criterion (t = 2.51,P = 0.046). The energy intensity of the θ-band and γ-band of the LFPs was significantly higher in rTMS group than in the control group ( t> 12.49,P < 0.001), θ-band and γ-band LFPs-spike were more synchronized ( t > 8.82, P < 0.001), but there was no significant difference in the average rate of spike between groups ( t = 1.73, P= 0.067).Conclusion High frequency rTMS could increase the LFPs energy in working memory experiment, enhance cooperative coding process for LFPs and spike, and improve the working memory ability of the rats.

Key words: repetitive transcranial magnetic stimulation, high frequency, working memory, local field potentials, spike, rats

CLC Number:

R741

TONG Yu-ming,XU Gui-zhi,GUO Miao-miao,ZHANG Tian-heng,WANG Ning. Effect of High Frequency Repetitive Transcranial Magnetic Stimulation on Local Field Potential and Spike Time-frequency Characteristics during Working Memory in Rats[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(12): 1401-1409.

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[1]	李江涛, 郑敏军, 曹辉. 经颅磁刺激技术的研究进展[J]. 高电压技术, 2016, 42(4):1168-1178.
	Li J T, Zheng M J, Cao H. Research progress in transcranial magnetic stimulation technology[J]. High Voltage Eng, 2016, 42(4):1168-1178.
[2]	Tremblay S, Rogasch N C, Premoli I, et al. Clinical utility and prospective of TMS-EEG[J]. Clin Neurophysiol, 2019, 130(5):802-844. doi: S1388-2457(19)30001-X pmid: 30772238
[3]	Nguyen J P, Suarez A, Saout E L, et al. Combining cognitive training and multi-site rTMS to improve cognitive functions in Alzheimer's disease[J]. Brain Stimul, 2018, 11(3):651-652. doi: 10.1016/j.brs.2018.02.013
[4]	Málly J, Stone T W, Sinkó G, et al. Long term follow-up study of non-invasive brain stimulation (NBS) (rTMS and tDCS) in Parkinson's disease (PD). Strong age-dependency in the effect of NBS[J]. Brain Res Bull, 2018, 142:78-87. doi: 10.1016/j.brainresbull.2018.06.014
[5]	黄娜雁, 宋鲁平, 童志前, 等. 重复经颅磁刺激治疗阿尔茨海默病的应用进展[J]. 中国康复理论与实践, 2019, 25(3):261-266.
	Huang N Y, Song L P, Tong Z Q, et al. Advance in repetitive transcranial magnetic stimulation for Alzheimer's disease[J]. Chin J Rehabil Theory Pract, 2019, 25(3):261-266.
[6]	Nguyen J P, Suarez A, Kemoun G, et al. Repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease[J]. Clin Neurophysiol, 2017, 47(1):47-53. doi: 10.1016/j.neucli.2017.01.001
[7]	Kaur M, Michael J A, Fitzgibbon B M, et al. Low-frequency rTMS is better tolerated than high-frequency rTMS in healthy people: empirical evidence from a single session study[J]. J Psychiatr Res, 2019, 113:79-82. doi: 10.1016/j.jpsychires.2019.03.015
[8]	向艳平, 唐锋, 肖锋, 等. 不同频率重复经颅磁刺激对脊髓损伤大鼠运动功能的影响[J]. 中国康复医学杂志, 2013, 28(1):3-8.
	Xiang Y P, Tang F, Xiao F, et al. Effects of repetitive transcranial magnetic stimulation of different frequencies on motor function of rats with spinal cord injury[J]. Chin J Rehabil Med, 2013, 28(1):3-8.
[9]	吴越, 徐文炜, 刘晓伟. 不同频率重复经颅磁刺激对阿尔茨海默病患者认知功能的影响[J]. 实用医学杂志, 2015, 31(10):1624-1627.
	Wu Y, Xu W W, Liu X W. Effect of repetitive transcranial magnetic stimulation with different frequency on cognitive function in patients with Alzheimer's disease[J]. J Pract Med, 2015, 31(10):1624-1627.
[10]	Baddeley A. Working memory[J]. Science, 1992, 255(5044):556-559. doi: 10.1126/science.1736359
[11]	Neary D. The prefrontal cortex[J]. Brain, 1999, 21(2):195-200.
[12]	Vertes R P. Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat[J]. Neuroscience, 2006, 142(1):1-20. doi: 10.1016/j.neuroscience.2006.06.027
[13]	Wimmer K, Nykamp D Q, Constantinidis C, et al. Bump attractor dynamics in prefrontal cortex explains behavioral precision in spatial working memory[J]. Nat Neurosci, 2014, 17(3):431-439. doi: 10.1038/nn.3645 pmid: 24487232
[14]	Stokes M G, Kusunoki M, Sigala N, et al. Dynamic coding for cognitive control in prefrontal cortex[J]. Neuron, 2013, 78(2):364-375. doi: 10.1016/j.neuron.2013.01.039 pmid: 23562541
[15]	Gao C, Zhang L, Luo D, et al. PFC activity pattern during verbal WM task in healthy male and female subjects: a NIRS study [M]. Berlin: Springer International Publishing, 2016: 187-193.
[16]	Hulst H E, Goldschmidt T, Nitsche M A, et al. rTMS affects working memory performance, brain activation and functional connectivity in patients with multiple sclerosis[J]. J Neurol Neurosurg Psychiatry, 2017, 88(5):386-394. doi: 10.1136/jnnp-2016-314224
[17]	李艳敏. 左侧背外侧前额叶高频重复经颅磁刺激对健康青年人认知功能的影响及其神经电生理、脑代谢机制[D]. 石家庄: 河北医科大学, 2017.
	Li Y M. The effects of high frequency repetitive transcranial magnetic stimulation over the left DLPFC on the cognitive function in healthy young people and its electrophysiological, metabolic mechanism[D]. Shijiazhuang: Hebei Medical University, 2017.
[18]	李双燕, 温雪晗, 桑浩钧, 等. 工频电磁场长期作用影响工作记忆中局部场电位因果网络连接特征[J]. 生物医学工程学杂志, 2018, 35(6):829-836.
	Li S Y, Wen X H, Sang H J, et al. Long term power frequency electromagnetic fields exposure influences the causal network connection pattern of local field potentials during working memory[J]. J Biomed Eng, 2018, 35(6):829-836.
[19]	Fries P, Reynolds J H, Rorie A E, et al. Modulation of oscillatory neuronal synchronization by selective visual attention[J]. Science, 2001, 291(5508):1560-1563. doi: 10.1126/science.1055465
[20]	Scherberger H, Jarvis M R, Andersen R A. Cortical local field potential encodes movement intentions in the posterior parietal cortex[J]. Neuron, 2005, 46(2):347-354. pmid: 15848811
[21]	Ruff D A, Cohen M R. Attention increases spike count correlations between visual cortical areas[J]. J Neurosci, 2016, 36(28):7523-7534. doi: 10.1523/JNEUROSCI.0610-16.2016
[22]	Constantinidis C, Funahashi S, Lee D, et al. Persistent spiking activity underlies working memory[J]. J Neurosci, 2018, 38(32):7020-7028. doi: 10.1523/JNEUROSCI.2486-17.2018
[23]	Vertes R P. Hippocampal theta rhythm: a tag for short-term memory[J]. Hippocampus, 2005, 15(7):923-935. doi: 10.1002/(ISSN)1098-1063
[24]	窦萌萌. 低频rTMS增强工作记忆gamma振荡的脑网络机制研究[D]. 天津:天津医科大学, 2017.
	Dou M M. An gamma oscillation enhancement in working memory by low-frequency rTMS[D]. Tianjin: Tianjin Medical University, 2017.
[25]	Kimura R, Saiki A, Fujiwara-Tsukamoto Y, et al. Large-scale analysis reveals populational contributions of cortical spike rate and synchrony to behavioural functions[J]. J Physiol, 2017, 595(1):385. doi: 10.1113/JP272794
[26]	Li S, Ouyang M, Liu T, et al. Increase of spike-LFP coordination in rat prefrontal cortex during working memory[J]. Behav Brain Res, 2014, 261(6):297-304. doi: 10.1016/j.bbr.2013.12.030
[27]	Pahor A, Jaušovec N. The role of theta and gamma oscillations in working memory[J]. Brain Stimul, 2015, 8(2):327.
[28]	Rey H G, Pedreira C, Quiroga R Q. Past, present and future of spike sorting techniques[J]. Brain Res Bull, 2015, 119:106-117. doi: 10.1016/j.brainresbull.2015.04.007

Effect of High Frequency Repetitive Transcranial Magnetic Stimulation on Local Field Potential and Spike Time-frequency Characteristics during Working Memory in Rats

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