帕金森病患者不同焦虑程度在汉密尔顿焦虑量表的结构差异

doi:10.3969/j.issn.1006-9771.2021.03.013

Abstract

Abstract: Objective

To explore the structural differences in series scores of Hamilton Anxiety Scale (HAMA) in Parkinson's disease patients with anxiety.

Methods

From January, 2016 to December, 2017, 180 inpatients with Parkinson's disease in Center for Neurodegenerative Disease, Beijing Tiantan Hospital were reviewed. Their age, gender, course of disease were recorded, and were assessed with HAMA, Hamilton Depression Scale (HAMD), unified Parkinson's Disease Rating Scale III (UPDRSIII)，Hoehn-Yahr stage and Mini-Mental State Examination (MMSE). They were divided into non-anxiety group, possible anxiety group, anxiety group and very anxiety group according to the scores of HAMA. The demographics, clinical data and series scores of HAMA were compared among these groups. The correlation between HAMA and HAMD were anlyzed.

Results

The course of disease, UPDRSIII scores and the most improvement ratio by drug increased with the severities of anxiety (F > 4.951, P < 0.001), as well as the series scores of HAMA (F > 188.241, P < 0.001); however, the proportion of psychogenic anxiety score increased with the severities of anxiety. The scores of HAMA correlated with the scores of HAMD (r = 0.665, P < 0.05).

Conclusion

The more serious the anxiety is, the more psychogenic are in Parkinson's disease patients.

Key words: Parkinson's disease, anxiety, structural differences

CLC Number:

R742.5

Ying JIANG,Jin-ping FANG,Tao FENG,Hui-zi MA. Structural Differences in Series Scores of Hamilton Anxiety Scale in Parkinson's Disease Patients[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(3): 325-328.

Figures/Tables 2

References 16

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项目	无焦虑组 (n = 46)	可能焦虑组 (n = 48)	焦虑组 (n = 62)	明显焦虑组 (n = 24)	F/χ²值	P值
性别(男/女, n)	26/20	27/21	35/27	15/9	0.957	0.812
年龄(岁)	63.17±11.26	62.04±10.40	62.02±10.12	61.29±13.05	0.186	0.905
病程(年)	3.95±2.95	6.69±4.93	6.47±4.59	8.88±5.50	7.038	< 0.001
H-Y分期	2.52±0.80	2.43±0.82	2.48±0.74	2.65±0.88	0.435	0.730
UPDRSⅢ	26.77±10.78	30.52±14.45	32.60±14.07	39.21±12.00	4.963	< 0.001
抗帕金森病药物最大改善率(%)	26.41±16.23	30.05±20.55	37.40±17.96	40.50±17.41	4.951	< 0.001
MMSE	25.60±4.77	23.23±8.03	24.18±5.97	24.13±5.79	0.510	0.679
起病形式(n)					0.214	0.999
震颤	20	20	26	8
运动迟缓	24	17	26	13
其他	2	11	10	3

项目	无焦虑组 (n = 46)	可能焦虑组 (n = 48)	焦虑组 (n = 62)	明显焦虑组 (n = 24)	F值	P值
HAMA躯体性	3.04±1.49	7.40±2.22^a	10.55±1.64^a,b	13.08±2.15^a,b,c	211.883	< 0.001
HAMA精神性	1.61±1.45	4.38±1.83^a	7.69±1.85^a,b	11.21±2.17^a,b,c	188.241	< 0.001
HAMA总分	4.65±1.57	11.75±2.06^a	18.24±1.84^a,b	24.29±2.16^a,b,c	746.770	< 0.001
HAMD总分	4.52±2.97	11.36±6.36^a	17.08±5.02^a,b	23.83±6.48^a,b,c	88.848	< 0.001

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Structural Differences in Series Scores of Hamilton Anxiety Scale in Parkinson's Disease Patients

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