《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2022, Vol. 28 ›› Issue (4): 429-438.doi: 10.3969/j.issn.1006-9771.2022.04.009
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CAI Tongxin1,LEI Mincong1,ZHOU Yijun1,MENG Dianhuai1,2()
Received:
2021-12-14
Revised:
2022-03-29
Published:
2022-04-25
Online:
2022-05-05
Contact:
MENG Dianhuai
E-mail:dhdream@126.com
Supported by:
CAI Tongxin,LEI Mincong,ZHOU Yijun,MENG Dianhuai. Animal models of acquired heterotopic ossification: a systematic review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(4): 429-438.
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纳入文献 | 国家 | 动物种属 | n | 模型类别 | 模型设计 | 造模周期 | 成功率 | 主要评估指标 |
---|---|---|---|---|---|---|---|---|
Walton等[ (1983) | 美国 | 绵羊 | 42 | 肌肉损伤模型 | 反复钝力作用于羊大腿深层肌肉致钝挫伤诱导异位骨化。 | 3~12周 | 16.6% | 组织学分析 |
Moore-Lotridge等[ | 美国 | ABCC6缺陷小鼠 | 101 | 心脏毒素注射到双侧小腿后室肌诱导肌肉损伤,并抑制巨噬细胞介导的纳米羟基磷灰石消退。 | 4周 | 80% | X线 显微CT 组织学分析 能量色散 X 射线 | |
Yu等[ | 中国 | 雄性SD大鼠 | 80 | 跟腱切断模型 | 第1组:右后肢跟腱切断。 第2组:仅同类皮肤切口。 | 10周 | 第1组:100%。 第2组:0%。 | X线 组织学分析 实时定量PCR |
Tsailas等[ | 希腊 | 雄性新西兰白兔 | 18 | 肌肉损伤联合关节制动模型 | 石膏固定右膝和踝关节于过伸位+强制暴力活动按摩膝关节,每次5 min,每周6 d,持续5周。 | 10周 | 100% | X 线 |
Anthonissen等[ | 德国 | 雄性Wistar大鼠 | 20 | 髋关节损伤模型 | 右侧髋关节大转子尖端内侧钻通髓腔,股骨管扩孔至2 mm,钳夹臀大肌、臀中肌3 min。 | 12周 | 90% | 显微CT 改良Brooker评分 |
Anthonissen等[ | 德国 | 雄性Wistar大鼠 | 50 | 第1组:右髋关节手术+额外的关节周围肌肉损伤。 第2组:右髋关节手术+保护关节周围肌肉。 | 12周 | 第1组:96%,且程度更重。 第2组:86.9%。 | 显微CT 改良Brooker评分 | |
Li等[ | 美国 | 雄性C57BL/6 J小鼠 | 4 | 异位植入模型 | 双小腿肌注含BMP-2的水凝胶,右侧小腿肌注射心脏毒素。 | 2周 | 左侧:100%。 右侧:100%,且更明显。 | 显微CT 组织学分析 实时定量PCR 蛋白质印迹 |
Zotz等[ | 巴西 | 雄性Wistar大鼠 | 12 | 双侧髂嵴收集自体骨髓0.35 mL分别注入其双侧股四头肌中。 | 5周 | 100% | 血清碱性磷酸酶 组织学分析 火焰光度法评估股四头肌中钙含量 | |
Polfer等[ | 美国 | 雄性SD大鼠 | 41 | 爆炸伤模型 | 第1组:单纯暴露于爆炸超压 (120±7) kPa中。 第2组:股骨骨折和周围肌肉挤压伤后,损伤区股骨截肢。 第3组:1+2组干预措施。 | 2~4周 | 第1组:0%。 第2组:66.6%。 第3组:100%。 | X线 显微CT 组织学分析 |
Epperson等[ | 美国 | 雌性兰布莱绵羊 | 8 | 利用AID模拟军事场景爆炸,同时模拟战场中创伤因素(如骨损伤、止血带、细菌、负压创伤治疗)。 | 24周 | 63% | X线 显微CT 组织学分析 电子背散射分析 | |
Pavey等[ | 美国 | 雄性SD大鼠 | 48 | 爆炸伤模型+截肢部位接种1×106个细菌菌落。 第1组:接种耐甲氧西林金黄色葡萄球菌。 第2组:接种鲍曼不动杆菌。 第3组:接种不含细菌的载体。 | 12周 | 第1组:100%,且HO程度重。 第2组:100%。 第3组:100%。 | 显微CT 组织学分析 | |
Tannous等[ | 美国 | 雄性SD大鼠 | 12 | 局部暴露于水下烈性炸药所致高能爆炸中,行指定部位(7只前肢,5只后肢)爆炸截肢。 | 4~24周 | 100% | X线 | |
Peterson等[ | 美国 | C57BL/6 小鼠 | 50 | 烧伤模型 | 60 ℃铝块置于小鼠背部17秒,制造30%体表面积皮肤烫伤,后行左下肢跟腱切断术。 | 9~15周 | 100% | 显微CT |
Debaud等[ | 法国 | 雌性C57B16小鼠 | 21 | 脊髓损伤模型 | 第1组:脊髓损伤手术+右后肢外周神经切断+术中双侧腘绳肌心脏毒素注射。 第2组:相同的手术程序+术后第10天双侧心脏毒素注射。 第3组 :假脊髓损伤手术+右后肢外周神经切断+术中双侧腘绳肌心脏毒素注射。 | 4周 | 第1组:100%,且失神经支配侧异位骨化体积显著增加; 第2组:0%; 第3组:50 %。 | 显微CT 组织学分析 实时定量PCR |
Genêt等[ | 美国 | 雌性C57BL/6小鼠 | 113 | T7~T8间脊髓横断,且右侧腘绳肌内注射心脏毒素。 | 2周 | 99.12%,仅发生在注射心脏毒素侧肢体。 | X线 显微CT 组织学分析 实时定量PCR | |
Kang等[ | 美国 | 雄性C57/BL6小鼠 | 24 | 实验组:T10节段脊髓完全性损伤,后肢四头肌注射不同剂量(0 g、0.25 g、0.5 g) BMP-2。 对照组:假脊髓损伤+相应剂量BMP-2肌注。 | 2周 | 0.5 µg BMP-2可显著增加四头肌异位骨化含量。 0.25 µg BMP-2仅使实验组产生异位骨化。 0 µg BMP-2不能诱发异位骨化。 | 显微CT 组织学分析 实时定量PCR | |
Shi等[ | 中国 | 雄性 SD大鼠 | 66 | 脑损伤模型 | 重物撞击顶叶区制造轻度创伤性脑损伤结合右后肢跟腱切断术。 | 10周 | 100% | X线 组织学分析 |
Ju等[ | 中国 | 雄性SD大鼠 | 44 | 联合脑外伤+烧伤+跟腱切断术。 | 10周 | 100% | X线 组织学分析 实时定量PCR Western Blotting检测 | |
Brady等[ | 澳大利亚 | 雄性SD大鼠 | 36 | 第1组:三重损伤(脑外伤+股骨骨折+肌肉损伤)。 第2组:单纯外周损伤(假脑外伤+股骨骨折+肌肉损伤)。 第3组:假损伤对照组(假脑外伤+假股骨骨折+假肌肉损伤)。 | 6周 | 第1组:70%。 第2组:20%。 第3组;0%。 | 显微CT 组织学分析 实时定量PCR Western blotting检测 | |
Anthonissen等[ | 德国 | 雄性Wistar大鼠 | 40 | 第1组:单纯行髋关节手术。 第2组:髋关节手术+中度脑外伤。 第3组:髋关节手术+重度脑外伤。 第4组:仅重度脑外伤。 | 12周 | 第1组:90%。 第2、3组:100%,且3组比2组骨化体积增加。 第4组:0%。 | 显微CT 组织学分析 |
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